<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 75


HIVdb Algorithm: Comments & Scores
  • V75I is a relatively nonpolymorphic accessory mutation that usually occurs in combination with the multi-nucleoside resistance mutations F77L, F116Y and Q151M. V75I occasionally occurs alone and in this context its clinical significance is unknown.
  • V75M appears to cause intermediate-level d4T resistance and low-level ddI resistance.
  • V75S/A/L are nonpolymorphic mutations that appear to reduce susceptibility to d4T and ddI.
  • V75T causes high-level d4T resistance and intermediate-level ddI resistance.

Mutation3TCFTCABCAZTD4TDDITDF
V75A000010100
V75I5555555
V75L000010100
V75M0001040150
V75S000010100
V75T0010060300
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 75 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
4192
B
27421
C
8709
D
1603
F
728
G
1593
AE
5640
AG
2957
 
A
205
B
4133
C
551
D
127
F
82
G
146
AE
330
AG
78
75 V    I 0.9      I 1.0
T 0.5
I 1.2
M 1.0
T 0.7
I 0.8 T 0.8
M 0.8
I 0.8
M 1.3 A 0.7
M 0.7
I 0.7
T 2.2
M 2.2
I 1.6
T 1.3
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
V75A0054766100.00 
V75A>=1>=0254211110.400.000
V75AAZT>=04530  
V75ADDI>=0530  
V75AD4T>=0550  
V75AABC>=0460  
V75AD4T+3TC>=03274160.400.000
V75AAZT+3TC>=0233550.200.000
V75AD4T+DDI>=046291.900.000
V75AAZT+DDI>=057910.100.254
V75AABC+3TC>=028510.300.063
V75ATDF+3TC>=03740  
V75ATDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V75I0054766230.00 
V75I>=1>=0254216882.700.000
V75IAZT>=045330.600.000
V75IDDI>=0530  
V75ID4T>=05511.800.002
V75IABC>=04636.500.000
V75ID4T+3TC>=032741334.000.000
V75IAZT+3TC>=02335311.300.000
V75ID4T+DDI>=0462153.200.000
V75IAZT+DDI>=0579142.400.000
V75IABC+3TC>=028551.700.000
V75ITDF+3TC>=0374133.400.000
V75ITDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V75L00547661510.20 
V75L>=1>=0254211280.500.000
V75LAZT>=045310.200.820
V75LDDI>=0530  
V75LD4T>=0550  
V75LABC>=0460  
V75LD4T+3TC>=0327450.100.251
V75LAZT+3TC>=0233560.200.975
V75LD4T+DDI>=046210.200.838
V75LAZT+DDI>=057940.600.138
V75LABC+3TC>=02850  
V75LTDF+3TC>=03740  
V75LTDF+FTC>=035271.900.000
MutationNRTINNRTINumSeqNumMut% Mutantp
V75M0054766190.00 
V75M>=1>=0254218293.200.000
V75MAZT>=04530  
V75MDDI>=0530  
V75MD4T>=0550  
V75MABC>=0460  
V75MD4T+3TC>=03274812.400.000
V75MAZT+3TC>=02335341.400.000
V75MD4T+DDI>=046220.400.002
V75MAZT+DDI>=057950.800.000
V75MABC+3TC>=02850  
V75MTDF+3TC>=037471.800.000
V75MTDF+FTC>=035230.800.000
MutationNRTINNRTINumSeqNumMut% Mutantp
V75S005476610.00 
V75S>=1>=025421510.200.000
V75SAZT>=04530  
V75SDDI>=0530  
V75SD4T>=0550  
V75SABC>=0460  
V75SD4T+3TC>=03274120.300.000
V75SAZT+3TC>=0233510.000.135
V75SD4T+DDI>=04620  
V75SAZT+DDI>=05790  
V75SABC+3TC>=02850  
V75STDF+3TC>=037420.500.000
V75STDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V75T00547660  
V75T>=1>=0254213131.200.000
V75TAZT>=04530  
V75TDDI>=05323.700.000
V75TD4T>=05511.800.000
V75TABC>=0460  
V75TD4T+3TC>=03274361.000.000
V75TAZT+3TC>=0233550.200.000
V75TD4T+DDI>=0462224.700.000
V75TAZT+DDI>=057920.300.000
V75TABC+3TC>=02850  
V75TTDF+3TC>=03740  
V75TTDF+FTC>=03520  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 75.
Mutation pattern data is not available for V75.

A complete summary of additional in vitro susceptibility data for viruses with V75 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.