<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 74


HIVdb Algorithm: Comments & Scores
  • L74M is a polymorphic accessory mutation selected in patients receiving RAL, EVG, and DTG. Alone, it does not reduce INI susceptibility. But when it occurs in combination with other INI-resistance mutations, L74M contributes to reduced RAL, EVG, and DTG susceptibility.

MutationRALEVGDTG
L74M10105
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 74 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
338
B
5129
C
1766
D
150
F
228
G
140
AE
1503
AG
564
 
A
3
B
1003
C
4
D
8
F
12
G
1
AE
3
AG
4
74 L I 22
M 3.0
V 0.6
I 3.3
M 0.3
V 0.3
I 4.8
M 0.5
V 0.2
P 0.1
I 4.0
M 2.0
I 3.5
M 0.9
V 0.4
I 8.8
M 2.9
I 2.5
M 1.0
V 0.1
I 18
M 10
  M 4.7
I 4.5
V 0.2
 I 13 I 9.1   I 33
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 74.
Mutation pattern data is not available for L74.

A complete summary of additional in vitro susceptibility data for viruses with L74 obtained using other assays including the Antivirogram can be found here.