<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 72


HIVdb Algorithm: Comments & Scores

MutationRALEVGDTG
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 72 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
619
B
5260
C
1964
D
171
F
251
G
178
AE
1622
AG
684
 
A
5
B
1011
C
5
D
8
F
11
G
AE
1
AG
5
72 I V 82
A 0.2
T 0.2
R 0.2
V 35
T 0.3
N 0.1
V 32
T 0.5
S 0.1
A 0.1
V 75
T 0.6
G 0.6
V 48
T 0.8
V 12 V 88
T 0.6
A 0.2
V 26
T 0.9
 V 40 V 19
A 0.1
N 0.1
L 0.1
 V 75 V 46  V 100 V 40
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 72.
Mutation pattern data is not available for I72.

A complete summary of additional in vitro susceptibility data for viruses with I72 obtained using other assays including the Antivirogram can be found here.