<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 68


HIVdb Algorithm: Comments & Scores
  • Amino acid deletions (d) between codons 66 to 71 are rare and usually occur in combination with multiple TAMs, the Q151M mutation complex, or K65R. Deletions at position 67 are more often associated with multiple TAMs. Deletions at position 69 are more often associated with either the Q151M complex or K65R.
  • Double amino acid insertions between codons 66 to 71 most often align to codon 69 and occur in less than 1% of heavily treated persons. Together with TAMs, they confer high-level resistance to AZT, d4T, ddI, ABC and TDF and intermediate/high-level resistance to 3TC and FTC.

Mutation3TCFTCABCAZTD4TDDITDF 184I606015-10-1010-10 184V606015-10-1010-10 41L551015151010 67N005151555 67E005101055 67G005101055 67STH005101055 70R001030151010 210W551015151010 215Y551545451515 215F551545451515 219QENRW005101055 40F5555555 44DA0000000 118I0000000 215CDEIVS00102020105 215NAL00102020105 65R303045-15456060 65N151525-10252525 65E00100101010 70GE101015-10151515 70TSNQ1010100101010 74I003000600 74V003000600 115F004500015 62V5555555 75I5555555 77L55101010105 116Y55101010105 151L10103030303010 151M15156060606015 66i30304545454545 67i30304545454545 68i30304545454545 69i30304545454545 70i30304545454545 71i30304545454545 66d15153030303030 67d15153030303030 68d15153030303030 69d1515150151515 70d1515150151515 71d1515150151515 69D000010300 69N00055100 69G0010010105 75M0001040150 75T0010060300 75S000010100 75A000010100 75L000010100 348I000101000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 68 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
3444
B
23322
C
8513
D
1288
F
695
G
1370
AE
5379
AG
2725
 
A
175
B
4120
C
451
D
126
F
82
G
145
AE
333
AG
76
68 S G 1.6 G 3.6  G 1.5 G 1.4 G 1.9 G 7.7 G 4.0  G 6.5
N 0.6
G 3.6 G 1.7
R 0.5
G 5.7
N 0.8
C 0.8
R 0.8
G 1.3 G 2.1
D 0.7
G 11 G 2.7
N 1.3
R 1.3
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
S68G004522715573.40 
S68G>=1056042524.400.000
S68G>=0>=11533210807.000.000
S68GAZT>=0453173.700.818
S68GDDI>=05323.700.806
S68GD4T>=05535.400.655
S68GABC>=04636.500.459
S68G>=0NVP40413237.900.000
S68G>=0EFV33771725.000.000
S68G>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68I004522760.00 
S68I>=10560420.000.485
S68I>=0>=11533210.000.813
S68IAZT>=04530  
S68IDDI>=0530  
S68ID4T>=0550  
S68IABC>=0460  
S68I>=0NVP40410  
S68I>=0EFV33770  
S68I>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68K004522720.00 
S68K>=1056040  
S68K>=0>=115332160.100.000
S68KAZT>=04530  
S68KDDI>=0530  
S68KD4T>=0550  
S68KABC>=0460  
S68K>=0NVP404120.000.033
S68K>=0EFV337720.000.016
S68K>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68N0045227900.10 
S68N>=105604120.200.938
S68N>=0>=115332780.500.000
S68NAZT>=04530  
S68NDDI>=0530  
S68ND4T>=0550  
S68NABC>=0460  
S68N>=0NVP4041210.500.000
S68N>=0EFV3377150.400.006
S68N>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68R0045227190.00 
S68R>=10560490.100.001
S68R>=0>=115332350.200.000
S68RAZT>=04530  
S68RDDI>=0530  
S68RD4T>=0550  
S68RABC>=0460  
S68R>=0NVP404130.000.589
S68R>=0EFV337740.100.119
S68R>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68T0045227200.00 
S68T>=10560430.000.975
S68T>=0>=115332130.000.097
S68TAZT>=04530  
S68TDDI>=0530  
S68TD4T>=0550  
S68TABC>=0460  
S68T>=0NVP404110.000.860
S68T>=0EFV337710.000.975
S68T>=0ETR00  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 68.
Mutation pattern data is not available for S68.

A complete summary of additional in vitro susceptibility data for viruses with S68 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.