<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 68


HIVdb Algorithm: Comments & Scores
  • Amino acid deletions (d) between codons 66 to 71 are rare and usually occur in combination with multiple TAMs, the Q151M mutation complex, or K65R. Deletions at position 67 are more often associated with multiple TAMs. Deletions at position 69 are more often associated with either the Q151M complex or K65R.
  • Double amino acid insertions between codons 66 to 71 most often align to codon 69 and occur in less than 1% of heavily treated persons. Together with TAMs, they confer high-level resistance to AZT, d4T, ddI, ABC and TDF and intermediate/high-level resistance to 3TC and FTC.

Mutation3TCFTCABCAZTD4TDDITDF
S68del15153030303030
S68ins30304545454545
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 68 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
5908
B
37839
C
11132
D
1662
F
1155
G
1327
AE
10362
AG
3905
 
A
286
B
4182
C
1225
D
120
F
80
G
137
AE
342
AG
81
68 S G 1.9
N 0.3
R 0.1
G 4.3
N 0.1
G 0.4
N 0.1
G 1.7
N 0.7
T 0.2
R 0.1
G 3.1
N 0.2
G 1.2
T 0.2
G 7.1
N 0.1
G 4.5
T 0.3
N 0.2
 G 4.1
N 0.4
G 3.6
N 0.2
G 1.4
N 0.3
R 0.2
K 0.2
T 0.1
G 6.0
N 0.9
R 0.9
G 1.3 G 2.2 G 12
R 0.3
I 0.3
G 2.5
N 1.2
D 1.2
R 1.2
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
S68C008030660.00 
S68C>=10683320.000.251
S68C>=0>=13242540.000.663
S68CAZT>=04730  
S68CDDI>=0540  
S68CD4T>=0550  
S68CABC>=0500  
S68C>=0NVP60360  
S68C>=0EFV801510.000.858
S68C>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68D008030620.00 
S68D>=10683320.000.027
S68D>=0>=13242550.000.038
S68DAZT>=047310.200.000
S68DDDI>=0540  
S68DD4T>=0550  
S68DABC>=0500  
S68D>=0NVP603610.000.511
S68D>=0EFV801520.000.048
S68D>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68G008030631773.90 
S68G>=1068332974.300.121
S68G>=0>=13242526258.000.000
S68GAZT>=0473183.800.964
S68GDDI>=05423.700.799
S68GD4T>=05535.400.823
S68GABC>=05036.000.705
S68G>=0NVP60365048.300.000
S68G>=0EFV80156037.500.000
S68G>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68I008030660.00 
S68I>=10683320.000.251
S68I>=0>=13242540.000.663
S68IAZT>=04730  
S68IDDI>=0540  
S68ID4T>=0550  
S68IABC>=0500  
S68I>=0NVP60360  
S68I>=0EFV80150  
S68I>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68K008030630.00 
S68K>=10683330.000.002
S68K>=0>=132425600.100.000
S68KAZT>=04730  
S68KDDI>=0540  
S68KD4T>=0550  
S68KABC>=05012.000.000
S68K>=0NVP603680.100.000
S68K>=0EFV8015200.200.000
S68K>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68N00803061890.20 
S68N>=106833270.300.015
S68N>=0>=1324253991.200.000
S68NAZT>=04730  
S68NDDI>=0540  
S68ND4T>=0550  
S68NABC>=0500  
S68N>=0NVP6036791.300.000
S68N>=0EFV80152112.600.000
S68N>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68R0080306360.00 
S68R>=106833110.100.000
S68R>=0>=132425810.200.000
S68RAZT>=04730  
S68RDDI>=0540  
S68RD4T>=0550  
S68RABC>=0500  
S68R>=0NVP6036110.100.000
S68R>=0EFV8015120.100.000
S68R>=0ETR10  
MutationNRTINNRTINumSeqNumMut% Mutantp
S68T0080306420.00 
S68T>=10683350.000.659
S68T>=0>=132425250.000.158
S68TAZT>=04730  
S68TDDI>=0540  
S68TD4T>=0550  
S68TABC>=0500  
S68T>=0NVP603620.000.733
S68T>=0EFV801540.000.867
S68T>=0ETR10  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 68.
Mutation pattern data is not available for S68.

A complete summary of additional in vitro susceptibility data for viruses with S68 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.