<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 62


HIVdb Algorithm: Comments & Scores
  • A62V is an accessory mutation that often occurs in combination with the multinucleoside resistance mutations K65R or Q151M-. Alone it does not reduce NRTI susceptibility. A62V is widespread in subtype A viruses in former Soviet Union countries but is otherwise nonpolymorphic.

Mutation3TCFTCABCAZTD4TDDITDF 184I606015-10-1010-10 184V606015-10-1010-10 41L551015151010 67N005151555 67E005101055 67G005101055 67STH005101055 70R001030151010 210W551015151010 215Y551545451515 215F551545451515 219QENRW005101055 40F5555555 44DA0000000 118I0000000 215CDEIVS00102020105 215NAL00102020105 65R303045-15456060 65N151525-10252525 65E00100101010 70GE101015-10151515 70TSNQ1010100101010 74I003000600 74V003000600 115F004500015 62V5555555 75I5555555 77L55101010105 116Y55101010105 151L10103030303010 151M15156060606015 66i30304545454545 67i30304545454545 68i30304545454545 69i30304545454545 70i30304545454545 71i30304545454545 66d15153030303030 67d15153030303030 68d15153030303030 69d1515150151515 70d1515150151515 71d1515150151515 69D000010300 69N00055100 69G0010010105 75M0001040150 75T0010060300 75S000010100 75A000010100 75L000010100 348I000101000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 62 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
3444
B
23322
C
8513
D
1288
F
695
G
1370
AE
5379
AG
2725
 
A
175
B
4120
C
451
D
126
F
82
G
145
AE
333
AG
76
62 A V 9.6      V 0.6   V 2.4 V 1.8 V 1.7 G 0.8 V 2.6 V 1.4 V 1.8  
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
A62P0048555130.00 
A62P>=1>=01979990.000.317
A62PAZT>=045310.200.301
A62PDDI>=0530  
A62PD4T>=0550  
A62PABC>=0460  
A62PD4T+3TC>=0298120.000.484
A62PAZT+3TC>=021290  
A62PD4T+DDI>=04640  
A62PAZT+DDI>=05140  
A62PABC+3TC>=02290  
A62PTDF+3TC>=02830  
A62PTDF+FTC>=01500  
MutationNRTINNRTINumSeqNumMut% Mutantp
A62T0048555120.00 
A62T>=1>=01979980.000.400
A62TAZT>=04530  
A62TDDI>=0530  
A62TD4T>=0550  
A62TABC>=0460  
A62TD4T+3TC>=0298110.000.764
A62TAZT+3TC>=0212910.000.950
A62TD4T+DDI>=046410.200.280
A62TAZT+DDI>=05140  
A62TABC+3TC>=02290  
A62TTDF+3TC>=02830  
A62TTDF+FTC>=01500  
MutationNRTINNRTINumSeqNumMut% Mutantp
A62V00485554200.80 
A62V>=1>=0197997733.900.000
A62VAZT>=045310.200.221
A62VDDI>=0530  
A62VD4T>=0550  
A62VABC>=0460  
A62VD4T+3TC>=029811374.500.000
A62VAZT+3TC>=02129421.900.000
A62VD4T+DDI>=0464112.300.001
A62VAZT+DDI>=051450.900.975
A62VABC+3TC>=022920.800.731
A62VTDF+3TC>=02833010.600.000
A62VTDF+FTC>=015032.000.291
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 62.
Mutation pattern data is not available for A62.

A complete summary of additional in vitro susceptibility data for viruses with A62 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.