<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 62


HIVdb Algorithm: Comments & Scores
  • A62V is an accessory mutation that often occurs in combination with the multinucleoside resistance mutations K65R or Q151M-. Alone it does not reduce NRTI susceptibility. A62V is widespread in subtype A viruses in former Soviet Union countries but is otherwise nonpolymorphic.

Mutation3TCFTCABCAZTD4TDDITDF
A62V5555555
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 62 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
3547
B
25466
C
8621
D
1320
F
723
G
1577
AE
5645
AG
2906
 
A
179
B
4133
C
461
D
127
F
82
G
146
AE
339
AG
78
62 A V 9.3      V 1.2   V 2.3 V 1.8 V 1.6 G 0.8 V 2.6 V 1.4 V 1.8  
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
A62P0051673130.00 
A62P>=1>=021996100.000.230
A62PAZT>=045310.200.276
A62PDDI>=0530  
A62PD4T>=0550  
A62PABC>=0460  
A62PD4T+3TC>=0299820.000.442
A62PAZT+3TC>=022820  
A62PD4T+DDI>=04640  
A62PAZT+DDI>=05780  
A62PABC+3TC>=02290  
A62PTDF+3TC>=03050  
A62PTDF+FTC>=02010  
MutationNRTINNRTINumSeqNumMut% Mutantp
A62T0051673130.00 
A62T>=1>=02199690.000.368
A62TAZT>=04530  
A62TDDI>=0530  
A62TD4T>=0550  
A62TABC>=0460  
A62TD4T+3TC>=0299810.000.753
A62TAZT+3TC>=0228210.000.903
A62TD4T+DDI>=046410.200.285
A62TAZT+DDI>=05780  
A62TABC+3TC>=02290  
A62TTDF+3TC>=03050  
A62TTDF+FTC>=02010  
MutationNRTINNRTINumSeqNumMut% Mutantp
A62V00516734570.80 
A62V>=1>=0219968463.800.000
A62VAZT>=045310.200.210
A62VDDI>=0530  
A62VD4T>=0550  
A62VABC>=0460  
A62VD4T+3TC>=029981384.600.000
A62VAZT+3TC>=02282492.100.000
A62VD4T+DDI>=0464112.300.002
A62VAZT+DDI>=057861.000.865
A62VABC+3TC>=022920.800.737
A62VTDF+3TC>=03053110.100.000
A62VTDF+FTC>=020141.900.197
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 62.
Mutation pattern data is not available for A62.

A complete summary of additional in vitro susceptibility data for viruses with A62 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.