<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 51


HIVdb Algorithm: Comments & Scores
  • H51Y is an uncommon nonpolymorphic accessory mutation selected in patients receiving RAL and EVG. It is also selected in vitro by EVG and DTG. Alone, H51Y reduces EVG susceptibility 2 to 3-fold. It does not reduce RAL or DTG susceptibility. However, the combination of H51Y and R263K is associated with ~5-fold reduced DTG susceptibility.

MutationRALEVGDTG 51Y151510 66I15600 66A15600 66K606010 68V000 74M10105 92Q306010 92V30605 92G15305 95K10100 97A15105 114Y000 118R303010 121Y30305 128T000 138K151510 138A151510 138D000 140S303010 140A303010 140C303010 143C60100 143R60100 143H60100 143KSGA60100 145S0600 146P0600 147G0600 148H606020 148K606020 148R606020 151I000 151A15300 151L306015 153Y01510 153F01010 155H606010 155S30300 155T30300 157Q15150 163R15150 163K15150 230R15150 263K153015
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 51 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
337
B
3372
C
1116
D
138
F
222
G
151
AE
1097
AG
546
 
A
1
B
191
C
2
D
6
F
4
G
1
AE
1
AG
2
51 H           Q 0.5
D 0.5
      
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 51.
Mutation pattern data is not available for H51.

A complete summary of additional in vitro susceptibility data for viruses with H51 obtained using other assays including the Antivirogram can be found here.