<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 40


HIVdb Algorithm: Comments & Scores
  • E40F is a nonpolymorphic mutation selected by AZT and d4T. It usually occurs in combination with M41L, L210W and T215Y. In this context it is associated with reduced susceptibility to each of the NRTIs.

Mutation3TCFTCABCAZTD4TDDITDF
E40F5555555
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 40 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
4192
B
27421
C
8709
D
1603
F
728
G
1593
AE
5640
AG
2957
 
A
205
B
4133
C
551
D
127
F
82
G
146
AE
325
AG
78
40 E D 12 D 0.8 D 7.2 D 27 D 28 D 21 D 1.2 D 10  D 8.6
A 0.5
 D 4.0 D 27
F 0.9
A 0.9
D 18 D 7.9  D 6.6
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
E40A0049954460.00 
E40A>=10568630.000.477
E40A>=0>=120718100.000.082
E40AAZT>=04530  
E40ADDI>=0530  
E40AD4T>=0540  
E40AABC>=0470  
E40A>=0NVP424350.100.791
E40A>=0EFV38690  
E40A>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40D004995429986.00 
E40D>=1056861492.600.000
E40D>=0>=1207188404.000.000
E40DAZT>=0453245.200.597
E40DDDI>=05311.800.331
E40DD4T>=05435.500.882
E40DABC>=04712.100.418
E40D>=0NVP42433578.400.000
E40D>=0EFV38691513.900.000
E40D>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40F00499540  
E40F>=105686160.200.000
E40F>=0>=1207181360.600.000
E40FAZT>=04530  
E40FDDI>=0530  
E40FD4T>=0540  
E40FABC>=0470  
E40F>=0NVP424380.100.000
E40F>=0EFV386970.100.000
E40F>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40G0049954370.00 
E40G>=10568630.000.759
E40G>=0>=120718100.000.293
E40GAZT>=04530  
E40GDDI>=0530  
E40GD4T>=0540  
E40GABC>=0470  
E40G>=0NVP42430  
E40G>=0EFV386940.100.738
E40G>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40K0049954500.10 
E40K>=10568690.100.288
E40K>=0>=120718400.100.002
E40KAZT>=04530  
E40KDDI>=0530  
E40KD4T>=0540  
E40KABC>=0470  
E40K>=0NVP4243120.200.002
E40K>=0EFV386950.100.776
E40K>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40Q0049954200.00 
E40Q>=10568650.000.199
E40Q>=0>=120718110.000.577
E40QAZT>=04530  
E40QDDI>=0530  
E40QD4T>=0540  
E40QABC>=0470  
E40Q>=0NVP424330.000.587
E40Q>=0EFV386930.000.494
E40Q>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40R004995460.00 
E40R>=1056860  
E40R>=0>=12071860.000.209
E40RAZT>=04530  
E40RDDI>=0530  
E40RD4T>=0540  
E40RABC>=0470  
E40R>=0NVP42430  
E40R>=0EFV386940.100.001
E40R>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40V004995470.00 
E40V>=10568620.000.523
E40V>=0>=12071860.000.303
E40VAZT>=04530  
E40VDDI>=0530  
E40VD4T>=0540  
E40VABC>=0470  
E40V>=0NVP424320.000.324
E40V>=0EFV38690  
E40V>=0ETR00  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 40.
Mutation pattern data is not available for E40.

A complete summary of additional in vitro susceptibility data for viruses with E40 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.