<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 40


HIVdb Algorithm: Comments & Scores
  • E40F is a nonpolymorphic mutation selected by AZT and d4T. It usually occurs in combination with M41L, L210W and T215Y. In this context it is associated with reduced susceptibility to each of the NRTIs.

Mutation3TCFTCABCAZTD4TDDITDF 184I606015-10-1010-10 184V606015-10-1010-10 41L551015151010 67N005151555 67E005101055 67G005101055 67STH005101055 70R001030151010 210W551015151010 215Y551545451515 215F551545451515 219QENRW005101055 40F5555555 44DA0000000 118I0000000 215CDEIVS00102020105 215NAL00102020105 65R303045-15456060 65N151525-10252525 65E00100101010 70GE101015-10151515 70TSNQ1010100101010 74I003000600 74V003000600 115F004500015 62V5555555 75I5555555 77L55101010105 116Y55101010105 151L10103030303010 151M15156060606015 66i30304545454545 67i30304545454545 68i30304545454545 69i30304545454545 70i30304545454545 71i30304545454545 66d15153030303030 67d15153030303030 68d15153030303030 69d1515150151515 70d1515150151515 71d1515150151515 69D000010300 69N00055100 69G0010010105 75M0001040150 75T0010060300 75S000010100 75A000010100 75L000010100 348I000101000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 40 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
3444
B
23322
C
8513
D
1288
F
695
G
1370
AE
5379
AG
2725
 
A
175
B
4120
C
451
D
126
F
82
G
145
AE
333
AG
76
40 E D 13 D 0.9 D 7.2 D 28
A 0.5
D 29 D 21 D 1.0 D 10  D 9.8  D 3.7 D 28
F 0.9
A 0.9
D 18 D 7.2  D 6.8
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
E40A0044278410.00 
E40A>=10553920.000.268
E40A>=0>=115248100.000.411
E40AAZT>=04530  
E40ADDI>=0530  
E40AD4T>=0540  
E40AABC>=0460  
E40A>=0NVP399250.100.709
E40A>=0EFV33620  
E40A>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40D004427826896.00 
E40D>=1055391392.500.000
E40D>=0>=1152485753.700.000
E40DAZT>=0453245.200.556
E40DDDI>=05311.800.323
E40DD4T>=05435.500.899
E40DABC>=04612.100.425
E40D>=0NVP39923338.300.000
E40D>=0EFV33621253.700.000
E40D>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40F00442780  
E40F>=105539160.200.000
E40F>=0>=1152481310.800.000
E40FAZT>=04530  
E40FDDI>=0530  
E40FD4T>=0540  
E40FABC>=0460  
E40F>=0NVP399280.200.000
E40F>=0EFV336270.200.000
E40F>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40G0044278350.00 
E40G>=10553930.000.708
E40G>=0>=11524880.000.380
E40GAZT>=04530  
E40GDDI>=0530  
E40GD4T>=0540  
E40GABC>=0460  
E40G>=0NVP39920  
E40G>=0EFV336240.100.640
E40G>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40K0044278430.00 
E40K>=10553990.100.230
E40K>=0>=115248270.100.019
E40KAZT>=04530  
E40KDDI>=0530  
E40KD4T>=0540  
E40KABC>=0460  
E40K>=0NVP3992120.300.001
E40K>=0EFV336250.100.530
E40K>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40Q0044278170.00 
E40Q>=10553950.000.164
E40Q>=0>=11524880.000.616
E40QAZT>=04530  
E40QDDI>=0530  
E40QD4T>=0540  
E40QABC>=0460  
E40Q>=0NVP399230.000.492
E40Q>=0EFV336230.000.342
E40Q>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40R004427860.00 
E40R>=1055390  
E40R>=0>=11524840.000.497
E40RAZT>=04530  
E40RDDI>=0530  
E40RD4T>=0540  
E40RABC>=0460  
E40R>=0NVP39920  
E40R>=0EFV336230.000.015
E40R>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40V004427870.00 
E40V>=10553920.000.597
E40V>=0>=11524850.000.345
E40VAZT>=04530  
E40VDDI>=0530  
E40VD4T>=0540  
E40VABC>=0460  
E40V>=0NVP399220.000.360
E40V>=0EFV33620  
E40V>=0ETR00  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 40.
Mutation pattern data is not available for E40.

A complete summary of additional in vitro susceptibility data for viruses with E40 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.