<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 40


HIVdb Algorithm: Comments & Scores
  • E40F is a nonpolymorphic mutation selected by AZT and d4T. It usually occurs in combination with M41L, L210W and T215Y. In this context it is associated with reduced susceptibility to each of the NRTIs.

Mutation3TCFTCABCAZTD4TDDITDF
E40F5555555
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 40 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
5936
B
37469
C
11094
D
1841
F
1178
G
1357
AE
10347
AG
3856
 
A
282
B
4166
C
891
D
128
F
82
G
138
AE
340
AG
79
40 E D 12
A 0.1
Q 0.1
N 0.1
K 0.1
G 0.1
D 0.8 D 7.6
A 0.1
K 0.1
D 28
A 0.4
Q 0.1
N 0.1
V 0.1
D 32
G 0.1
D 24
A 0.1
Q 0.1
G 0.1
D 0.6
Q 0.3
A 0.1
G 0.1
D 10
A 0.1
Q 0.1
G 0.1
 D 8.0
A 0.4
F 0.4
D 0.2
K 0.1
D 4.4
R 0.1
D 27
A 0.8
D 20 D 9.8 Q 0.3
D 0.3
G 0.3
D 5.2
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
E40A0073088590.00 
E40A>=10625730.000.512
E40A>=0>=127613160.000.293
E40AAZT>=04540  
E40ADDI>=0530  
E40AD4T>=0540  
E40AABC>=0480  
E40A>=0NVP538150.000.956
E40A>=0EFV601110.000.136
E40A>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40D007308840405.50 
E40D>=1062571772.800.000
E40D>=0>=12761311534.100.000
E40DAZT>=0454255.500.933
E40DDDI>=05311.800.390
E40DD4T>=05435.500.773
E40DABC>=04812.000.467
E40D>=0NVP53814398.100.000
E40D>=0EFV60112694.400.001
E40D>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40F00730880  
E40F>=106257160.200.000
E40F>=0>=1276131500.500.000
E40FAZT>=04540  
E40FDDI>=0530  
E40FD4T>=0540  
E40FABC>=0480  
E40F>=0NVP538190.100.000
E40F>=0EFV601170.100.000
E40F>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40G0073088550.00 
E40G>=10625730.000.601
E40G>=0>=127613200.001.000
E40GAZT>=04540  
E40GDDI>=0530  
E40GD4T>=0540  
E40GABC>=0480  
E40G>=0NVP53810  
E40G>=0EFV601130.000.653
E40G>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40K0073088690.00 
E40K>=106257110.100.082
E40K>=0>=127613660.200.000
E40KAZT>=04540  
E40KDDI>=0530  
E40KD4T>=0540  
E40KABC>=0480  
E40K>=0NVP5381130.200.003
E40K>=0EFV6011100.100.137
E40K>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40Q0073088590.00 
E40Q>=10625750.000.834
E40Q>=0>=127613210.000.913
E40QAZT>=04540  
E40QDDI>=0530  
E40QD4T>=0540  
E40QABC>=0480  
E40Q>=0NVP538150.000.956
E40Q>=0EFV601160.000.793
E40Q>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40R007308870.00 
E40R>=1062570  
E40R>=0>=12761370.000.111
E40RAZT>=04540  
E40RDDI>=0530  
E40RD4T>=0540  
E40RABC>=0480  
E40R>=0NVP53810  
E40R>=0EFV601140.000.002
E40R>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
E40V007308880.00 
E40V>=10625720.000.404
E40V>=0>=127613220.000.000
E40VAZT>=04540  
E40VDDI>=0530  
E40VD4T>=0540  
E40VABC>=0480  
E40V>=0NVP538130.000.037
E40V>=0EFV60110  
E40V>=0ETR00  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 40.
Mutation pattern data is not available for E40.

A complete summary of additional in vitro susceptibility data for viruses with E40 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.