<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 333


HIVdb Algorithm: Comments & Scores

Mutation3TCFTCABCAZTD4TDDITDF
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 333 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
4458
B
33771
C
10461
D
1728
F
1070
G
1838
AE
8870
AG
3290
 
A
279
B
4138
C
849
D
129
F
82
G
146
AE
337
AG
86
333 G E 0.6
S 0.1
E 7.1
D 0.8
E 1.0
A 0.1
N 0.1
D 0.1
E 2.6
D 0.2
R 0.2
E 1.7
D 0.2
E 1.4
S 0.2
A 0.1
E 0.1
E 0.2   E 10.0
D 1.0
W 0.1
R 0.1
E 2.7
S 0.7
 E 6.7    
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
G333D0017410800.40 
G333D>=1>=09783640.600.042
G333DAZT>=01240  
G333DDDI>=030  
G333DD4T>=0170  
G333DABC>=000  
G333DD4T+3TC>=0130260.400.838
G333DAZT+3TC>=099020.200.348
G333DD4T+DDI>=012321.600.220
G333DAZT+DDI>=0680  
G333DABC+3TC>=01060  
G333DTDF+3TC>=045620.400.775
G333DTDF+FTC>=01430  
MutationNRTINNRTINumSeqNumMut% Mutantp
G333E00174107514.30 
G333E>=1>=097835715.800.000
G333EAZT>=0124118.800.024
G333EDDI>=030  
G333ED4T>=01715.800.780
G333EABC>=000  
G333ED4T+3TC>=01302272.000.000
G333EAZT+3TC>=0990474.700.567
G333ED4T+DDI>=012397.300.159
G333EAZT+DDI>=06822.900.797
G333EABC+3TC>=010654.700.975
G333ETDF+3TC>=045671.500.005
G333ETDF+FTC>=014353.400.786
MutationNRTINNRTINumSeqNumMut% Mutantp
G333R0017410100.00 
G333R>=1>=0978350.000.956
G333RAZT>=01240  
G333RDDI>=030  
G333RD4T>=0170  
G333RABC>=000  
G333RD4T+3TC>=0130210.000.753
G333RAZT+3TC>=09900  
G333RD4T+DDI>=01230  
G333RAZT+DDI>=0680  
G333RABC+3TC>=01060  
G333RTDF+3TC>=04560  
G333RTDF+FTC>=01430  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 333.
Mutation pattern data is not available for G333.

A complete summary of additional in vitro susceptibility data for viruses with G333 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.