<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 333


HIVdb Algorithm: Comments & Scores

Mutation3TCFTCABCAZTD4TDDITDF 184I606015-10-1010-10 184V606015-10-1010-10 41L551015151010 67N005151555 67E005101055 67G005101055 67STH005101055 70R001030151010 210W551015151010 215Y551545451515 215F551545451515 219QENRW005101055 40F5555555 44DA0000000 118I0000000 215CDEIVS00102020105 215NAL00102020105 65R303045-15456060 65N151525-10252525 65E00100101010 70GE101015-10151515 70TSNQ1010100101010 74I003000600 74V003000600 115F004500015 62V5555555 75I5555555 77L55101010105 116Y55101010105 151L10103030303010 151M15156060606015 66i30304545454545 67i30304545454545 68i30304545454545 69i30304545454545 70i30304545454545 71i30304545454545 66d15153030303030 67d15153030303030 68d15153030303030 69d1515150151515 70d1515150151515 71d1515150151515 69D000010300 69N00055100 69G0010010105 75M0001040150 75T0010060300 75S000010100 75A000010100 75L000010100 348I000101000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 333 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
3444
B
23322
C
8513
D
1288
F
695
G
1370
AE
5379
AG
2725
 
A
175
B
4120
C
451
D
126
F
82
G
145
AE
333
AG
76
333 G  E 7.1
D 0.7
E 0.9 E 3.8 E 2.7 E 1.4     E 10.0
D 1.0
E 3.8  E 6.7    
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
G333D0012723500.30 
G333D>=1>=07477550.700.002
G333DAZT>=01230  
G333DDDI>=030  
G333DD4T>=0170  
G333DABC>=000  
G333DD4T+3TC>=079430.300.821
G333DAZT+3TC>=04740  
G333DD4T+DDI>=011921.600.140
G333DAZT+DDI>=0570  
G333DABC+3TC>=0180  
G333DTDF+3TC>=09711.000.854
G333DTDF+FTC>=0200  
MutationNRTINNRTINumSeqNumMut% Mutantp
G333E00127235634.40 
G333E>=1>=074775086.700.000
G333EAZT>=0123118.900.028
G333EDDI>=030  
G333ED4T>=01715.800.765
G333EABC>=000  
G333ED4T+3TC>=0794192.300.008
G333EAZT+3TC>=0474265.400.325
G333ED4T+DDI>=011997.500.153
G333EAZT+DDI>=05723.501.000
G333EABC+3TC>=01815.500.733
G333ETDF+3TC>=09744.100.916
G333ETDF+FTC>=0200  
MutationNRTINNRTINumSeqNumMut% Mutantp
G333R001272390.00 
G333R>=1>=0747730.000.573
G333RAZT>=01230  
G333RDDI>=030  
G333RD4T>=0170  
G333RABC>=000  
G333RD4T+3TC>=07940  
G333RAZT+3TC>=04740  
G333RD4T+DDI>=01190  
G333RAZT+DDI>=0570  
G333RABC+3TC>=0180  
G333RTDF+3TC>=0970  
G333RTDF+FTC>=0200  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 333.
Mutation pattern data is not available for G333.

A complete summary of additional in vitro susceptibility data for viruses with G333 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.