<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 234


HIVdb Algorithm: Comments & Scores

MutationEFVNVPETRRPV
L234I0000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 234 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTNRTI (but no NNRTI) Treated Persons NNRTI Treated Persons
A
279
B
4149
C
850
D
129
F
82
G
146
AE
338
AG
87
 
A
1403
B
11872
C
6637
D
725
F
347
G
1024
AE
2053
AG
1127
234 L       H 0.3   I 0.2 I 0.2 I 0.3 I 0.4 I 0.3 I 0.3 I 0.2
F 0.1
I 0.2
S 0.1
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (No NNRTIs). The third row shows the frequency of the mutation in persons who have received one or more NNRTIs (+/- NRTIs). The following rows show the frequency of the mutation in persons who have received only a single NNRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
L234F0073731100.00 
L234F>=10533610.000.771
L234F>=0>=12578360.000.439
L234F>=0NVP509810.000.796
L234F>=0EFV56960  
L234F>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
L234I0073731110.00 
L234I>=10533610.000.722
L234I>=0>=125783790.300.000
L234I>=0NVP509820.000.457
L234I>=0EFV5696340.500.000
L234I>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
L234P0073731320.00 
L234P>=10533640.000.477
L234P>=0>=125783100.000.893
L234P>=0NVP509820.000.834
L234P>=0EFV56960  
L234P>=0ETR00  
MutationNRTINNRTINumSeqNumMut% Mutantp
L234V0073731130.00 
L234V>=10533610.000.635
L234V>=0>=12578310.000.194
L234V>=0NVP50980  
L234V>=0EFV56960  
L234V>=0ETR00  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 234.
Mutation pattern data is not available for L234.

A complete summary of additional in vitro susceptibility data for viruses with L234 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 24 nonpolymorphic NNRTI-resistance mutations shown to contribute decreased susceptibility to at least one NNRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.