<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 230


HIVdb Algorithm: Comments & Scores
  • S230N is a polymorphism that is not associated with reduced INI susceptibility.
  • S230R is a nonpolymorphic accessory mutation selected in vitro and in vivo by RAL and in vitro by EVG. It appears to have minimal, if any, effect on INI susceptibility.

MutationRALEVGDTG
S230R15150
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 230 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
338
B
5129
C
1766
D
150
F
228
G
140
AE
1503
AG
564
 
A
3
B
1003
C
4
D
8
F
12
G
1
AE
3
AG
4
230 S N 1.5 N 10
G 0.3
N 1.6 N 2.7 N 1.3 N 2.1 N 0.7
G 0.1
N 0.2   N 9.7
R 2.6
K 0.1
G 0.1
R 25  R 8.3   R 25
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 230.
Mutation pattern data is not available for S230.

A complete summary of additional in vitro susceptibility data for viruses with S230 obtained using other assays including the Antivirogram can be found here.