<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on protease mutations at position 23


HIVdb Algorithm: Comments & Scores
  • L23I is an uncommon nonpolymorphic mutation selected primarily by NFV. It causes low/intermediate-level resistance to NFV.

MutationFPV/rIDV/rNFVSQV/rLPV/rATV/rTPV/rDRV/r
L23I001500000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 23 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTPI Naive Persons PI Treated Persons
A
6234
B
43377
C
17206
D
2056
F
1260
G
2885
AE
12046
AG
5345
 
A
337
B
17023
C
2998
D
239
F
1533
G
385
AE
674
AG
261
23 L   F 0.1 P 0.1
I 0.1
Q 0.1   P 0.1   I 1.0
V 0.1
I 1.4 I 1.3
K 0.4
I 0.8
V 0.1
I 1.0 I 0.3 I 0.4
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are PI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more PIs. The following rows show the frequency of the mutation in persons who have received only a single PI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationPINumSeqNumMut% Mutantp
L23F097932680.00 
L23F>=126328210.000.670
L23FAPV760  
L23FIDV12030  
L23FLPV2272130.500.000
L23FNFV119710.000.713
L23FSQV4620  
L23FATV29010.300.511
L23FTPV00  
L23FDRV100  
MutationPINumSeqNumMut% Mutantp
L23I097932230.00 
L23I>=1263283451.300.000
L23IAPV760  
L23IIDV120310.000.697
L23ILPV227290.300.000
L23INFV1197131.000.000
L23ISQV46230.600.000
L23IATV29041.300.000
L23ITPV00  
L23IDRV100  
MutationPINumSeqNumMut% Mutantp
L23P097932230.00 
L23P>=12632850.000.841
L23PAPV760  
L23PIDV120320.100.029
L23PLPV22720  
L23PNFV11970  
L23PSQV4620  
L23PATV29010.300.106
L23PTPV00  
L23PDRV100  
MutationPINumSeqNumMut% Mutantp
L23V097932170.00 
L23V>=126328170.000.000
L23VAPV7611.300.000
L23VIDV120310.000.545
L23VLPV227210.000.885
L23VNFV119710.000.542
L23VSQV4620  
L23VATV2900  
L23VTPV00  
L23VDRV100  
Footnote: Data are not shown for TPV or DRV because there are no data available from persons who have developed virological failure after receiving just one of these PIs; About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 23.
Mutation pattern data is not available for L23.

A complete summary of additional in vitro susceptibility data for viruses with L23 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 35 nonpolymorphic PI-resistance mutations shown to contribute decreased susceptibility to at least one PI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.