<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on protease mutations at position 23


HIVdb Algorithm: Comments & Scores
  • L23I is an uncommon nonpolymorphic mutation selected primarily by NFV. It causes low/intermediate-level resistance to NFV.

MutationFPV/rIDV/rNFVSQV/rLPV/rATV/rTPV/rDRV/r 10F10101005005 10I00000000 10R00000000 10V00000000 10Y00000000 11I50000005 11L50000005 13V00000000 20I001000000 20M00000000 20R00000000 20T551000500 20V00500000 23I001500000 24I101010101010-50 24F55555500 24M55555500 30N006000000 32I30151501515515 33F1005055105 33V00000000 33I00000000 35G00500050 36I00000000 36L00000000 36V00000000 36T00000000 43T000000100 46I1010205101050 46L10102051010100 46V101020551050 47V30151501553010 47A60153006053010 48V0103060103000 48M0103060103000 48A0103060101000 48S0103060101000 48T0103060101000 48Q0103060101000 48L0103060101000 50V6001515300-520 50L-5-5-5-5-1060-5-10 53L0001501000 53Y00000000 54L601020151515-1020 54M6015201515152020 54S101520151015200 54T101520151015200 54V101520151515200 54A101520151015200 58E005005150 63P00000000 71T00000000 71V00000000 71I50550500 71L50550500 73C510151551000 73S510151551000 73T510151551000 73A510151551000 73V55555500 74P10101510510205 74S001500000 76V60300-530-5-520 77I00000000 82A15303015301500 82F303030103015015 82I00000000 82S103030102525250 82T103030102525450 82M103030102510100 82L151010101010450 82C101010101010100 83D0101010010200 84A6060606060606030 84V6060606030603015 84C6060606030603010 85V00000000 88D003050500 88S-101560150600-5 88T0030001500 88G0030001500 89V55500005 89I00000000 89M00000000 89T00000000 90M20306040152500 93L00000000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 23 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTPI Naive Persons PI Treated Persons
A
4155
B
25465
C
9974
D
1649
F
1084
G
1380
AE
5827
AG
3694
 
A
214
B
9433
C
1063
D
241
F
1522
G
260
AE
115
AG
140
23 L          I 0.5 I 1.0 I 1.3 I 0.8  I 0.8   
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are PI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more PIs. The following rows show the frequency of the mutation in persons who have received only a single PI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationPINumSeqNumMut% Mutantp
L23F053991290.00 
L23F>=11320980.000.924
L23FAPV600  
L23FIDV11750  
L23FLPV89940.400.000
L23FNFV115610.000.869
L23FSQV4540  
L23FATV2090  
L23FTPV00  
L23FDRV80  
MutationPINumSeqNumMut% Mutantp
L23I053991120.00 
L23I>=1132091491.100.000
L23IAPV600  
L23IIDV117510.000.668
L23ILPV89920.200.007
L23INFV1156121.000.000
L23ISQV45430.600.000
L23IATV20931.400.000
L23ITPV00  
L23IDRV80  
MutationPINumSeqNumMut% Mutantp
L23P053991140.00 
L23P>=11320920.000.685
L23PAPV600  
L23PIDV117510.000.747
L23PLPV8990  
L23PNFV11560  
L23PSQV4540  
L23PATV20910.400.065
L23PTPV00  
L23PDRV80  
MutationPINumSeqNumMut% Mutantp
L23V053991100.00 
L23V>=11320950.000.313
L23VAPV600  
L23VIDV117510.000.579
L23VLPV8990  
L23VNFV11560  
L23VSQV4540  
L23VATV2090  
L23VTPV00  
L23VDRV80  
Footnote: Data are not shown for TPV or DRV because there are no data available from persons who have developed virological failure after receiving just one of these PIs; About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 23.
Mutation pattern data is not available for L23.

A complete summary of additional in vitro susceptibility data for viruses with L23 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 35 nonpolymorphic PI-resistance mutations shown to contribute decreased susceptibility to at least one PI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.