<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on protease mutations at position 23


HIVdb Algorithm: Comments & Scores
  • L23I is an uncommon nonpolymorphic mutation selected primarily by NFV. It causes low/intermediate-level resistance to NFV.

MutationFPV/rIDV/rNFVSQV/rLPV/rATV/rTPV/rDRV/r
L23I001500000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 23 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTPI Naive Persons PI Treated Persons
A
4928
B
29679
C
10466
D
1981
F
1111
G
1584
AE
6172
AG
4278
 
A
262
B
9557
C
1208
D
299
F
1526
G
339
AE
186
AG
215
23 L           I 1.0 I 1.3 I 0.7  I 0.9   
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are PI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more PIs. The following rows show the frequency of the mutation in persons who have received only a single PI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationPINumSeqNumMut% Mutantp
L23F060678320.00 
L23F>=11370480.000.956
L23FAPV610  
L23FIDV11770  
L23FLPV106640.300.000
L23FNFV117010.000.874
L23FSQV4540  
L23FATV2100  
L23FTPV00  
L23FDRV80  
MutationPINumSeqNumMut% Mutantp
L23I060678150.00 
L23I>=1137041521.100.000
L23IAPV610  
L23IIDV117710.000.721
L23ILPV106630.200.000
L23INFV1170131.100.000
L23ISQV45430.600.000
L23IATV21031.400.000
L23ITPV00  
L23IDRV80  
MutationPINumSeqNumMut% Mutantp
L23P060678180.00 
L23P>=11370420.000.494
L23PAPV610  
L23PIDV117710.000.816
L23PLPV10660  
L23PNFV11700  
L23PSQV4540  
L23PATV21010.400.089
L23PTPV00  
L23PDRV80  
MutationPINumSeqNumMut% Mutantp
L23V060678120.00 
L23V>=11370440.000.722
L23VAPV610  
L23VIDV117710.000.608
L23VLPV10660  
L23VNFV11700  
L23VSQV4540  
L23VATV2100  
L23VTPV00  
L23VDRV80  
Footnote: Data are not shown for TPV or DRV because there are no data available from persons who have developed virological failure after receiving just one of these PIs; About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 23.
Mutation pattern data is not available for L23.

A complete summary of additional in vitro susceptibility data for viruses with L23 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 35 nonpolymorphic PI-resistance mutations shown to contribute decreased susceptibility to at least one PI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.