<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 163


HIVdb Algorithm: Comments & Scores
  • G163RK are polymorphic accessory INI-resistance mutation that usually occur in combination with N155H in patients receiving RAL (Markowitz et al. 2007; Merck 2009). They do not appear to reduce INI susceptibility (Shimura et al. 2007).
  • G163RK are polymorphic accessory INI-resistance mutation that usually occur in combination with N155H in patients receiving RAL (Markowitz et al. 2007; Merck 2009). They do not appear to reduce INI susceptibility (Shimura et al. 2007).

MutationRALEVG
G163K50
G163R50
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 163 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
295
B
3270
C
1079
D
138
F
222
G
151
AE
751
AG
552
 
A
1
B
183
C
2
D
6
F
4
G
1
AE
1
AG
2
163 G E 0.7 E 5.2
Q 0.6 		E 2.4
V 0.7
Q 0.5 		T 3.7
E 2.9
A 0.7
V 0.7 		R 8.3
K 6.0
S 5.5
E 4.1
T 1.8
A 1.4
N 0.9
H 0.5
Q 0.5 		A 2.6
T 0.7
K 0.7
E 0.7
V 0.7 		E 1.1 E 2.6
A 0.9
V 0.5 		  E 3.4
R 2.9
Q 1.7
K 1.7
S 0.6 		      
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 163.
Mutation pattern data is not available for G163.

A complete summary of additional in vitro susceptibility data for viruses with G163 obtained using other assays including the Antivirogram can be found here.

Database

Resources

Team