<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 154


HIVdb Algorithm: Comments & Scores

MutationRALEVGDTG
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 154 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
619
B
5260
C
1964
D
171
F
251
G
178
AE
1622
AG
684
 
A
5
B
1011
C
4
D
8
F
11
G
AE
1
AG
5
154 M I 0.3
L 0.2
I 2.3
L 2.0
I 0.2
T 0.1
R 0.1
L 0.1
V 0.1
T 0.6 I 2.8
L 0.4
 I 2.9
L 0.2
T 0.1
K 0.1
I 0.7
T 0.1
  I 4.0
L 2.5
  L 9.1    
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 154.
Mutation pattern data is not available for M154.

A complete summary of additional in vitro susceptibility data for viruses with M154 obtained using other assays including the Antivirogram can be found here.