<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 151


HIVdb Algorithm: Comments & Scores
  • Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 62, 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC.
  • Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC. Q151L is an extremely rare transitional mutation that may precede the emergence of the Q151M.

Mutation3TCFTCABCAZTD4TDDITDF
Q151L10103030303010
Q151M15156060606015
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 151 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
4192
B
27421
C
8709
D
1603
F
728
G
1593
AE
5640
AG
2957
 
A
205
B
4133
C
551
D
127
F
82
G
146
AE
325
AG
78
151 Q          M 1.0 M 1.6 M 1.2 M 0.8  M 0.7 M 2.8  
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151H005479360.00 
Q151H>=1>=02542260.000.292
Q151HAZT>=04530  
Q151HDDI>=0530  
Q151HD4T>=0550  
Q151HABC>=0470  
Q151HD4T+3TC>=0326920.000.107
Q151HAZT+3TC>=022960  
Q151HD4T+DDI>=04640  
Q151HAZT+DDI>=05780  
Q151HABC+3TC>=028510.300.015
Q151HTDF+3TC>=03690  
Q151HTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151K005479380.00 
Q151K>=1>=02542230.001.000
Q151KAZT>=04530  
Q151KDDI>=0530  
Q151KD4T>=0550  
Q151KABC>=0470  
Q151KD4T+3TC>=0326950.100.000
Q151KAZT+3TC>=0229630.100.002
Q151KD4T+DDI>=046420.400.000
Q151KAZT+DDI>=05780  
Q151KABC+3TC>=02850  
Q151KTDF+3TC>=03690  
Q151KTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151L005479320.00 
Q151L>=1>=025422200.000.000
Q151LAZT>=04530  
Q151LDDI>=0530  
Q151LD4T>=0550  
Q151LABC>=0470  
Q151LD4T+3TC>=0326950.100.000
Q151LAZT+3TC>=0229630.100.000
Q151LD4T+DDI>=046430.600.000
Q151LAZT+DDI>=05780  
Q151LABC+3TC>=02850  
Q151LTDF+3TC>=03690  
Q151LTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151M00547930  
Q151M>=1>=0254227042.700.000
Q151MAZT>=04530  
Q151MDDI>=0530  
Q151MD4T>=05511.800.000
Q151MABC>=04712.100.000
Q151MD4T+3TC>=032691163.500.000
Q151MAZT+3TC>=02296120.500.000
Q151MD4T+DDI>=0464265.600.000
Q151MAZT+DDI>=0578162.700.000
Q151MABC+3TC>=028531.000.000
Q151MTDF+3TC>=036941.000.000
Q151MTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151P0054793100.00 
Q151P>=1>=02542240.000.975
Q151PAZT>=04530  
Q151PDDI>=0530  
Q151PD4T>=0550  
Q151PABC>=0470  
Q151PD4T+3TC>=032690  
Q151PAZT+3TC>=0229610.000.929
Q151PD4T+DDI>=04640  
Q151PAZT+DDI>=057810.100.253
Q151PABC+3TC>=02850  
Q151PTDF+3TC>=03690  
Q151PTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
Q151R0054793200.00 
Q151R>=1>=025422100.001.000
Q151RAZT>=04530  
Q151RDDI>=0530  
Q151RD4T>=0550  
Q151RABC>=0470  
Q151RD4T+3TC>=032690  
Q151RAZT+3TC>=022960  
Q151RD4T+DDI>=04640  
Q151RAZT+DDI>=05780  
Q151RABC+3TC>=02850  
Q151RTDF+3TC>=03690  
Q151RTDF+FTC>=03520  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 151.
Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.

A complete summary of additional in vitro susceptibility data for viruses with Q151 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with Q151 (not just the top 10 most frequent patterns) can be found at this page.

Mutation PatternsNumber of
Sequences
AZT
foldn
TDF
foldn
ABC
foldn
3TC
foldn
151M,184V11312640.822132004
151M1097.0101.095.5103.016
115F,151M,184V7578621.922022003
65R,151M6910134.93182363
65R,151M,184V42    
65R,70R,151M29    
65R,115F,151M,184V2698517.51 1001
67N,151M,184V174.620.318.522003
115F,151M17    
151M,184I17    
Footnote: Mutation patterns were defined by the presence or absence of major NRTI drug resistance mutations ; Sequences containing a mixture at a major drug resistance positions were excluded; For the cutoffs defined by PhenoSense, open the sample report form provided on this page; The full list of all mutation patterns are also available here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.