Mutation ARV - Evidence

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MARVEL on integrase mutations at position 151

HIVdb Algorithm: Comments & Scores

V151A is an extremely rare nonpolymorphic mutation selected in vitro by an investigational INI. It has been reported to reduce susceptibility to RAL by 4-fold and to EVG by 12-fold.
V151I is a polymorphic mutation selected in patients receiving RAL and in vitro by EVG. It appears to have little or no effect on INI susceptibility.
V151L is an extremely rare nonpolymorphic mutation selected in vitro by early investigational INIs but not in patients receiving current INIs. It reduces susceptibility to RAL, EVG, and DTG by ~10, ~40, and 3-fold, respectively.

Mutation	RAL	EVG	DTG 51	Y	15	15	10 66	I	15	60	0 66	A	15	60	0 66	K	60	60	10 68	V	0	0	0 74	M	10	10	5 92	Q	30	60	10 92	V	30	60	5 92	G	15	30	5 95	K	10	10	0 97	A	15	10	5 114	Y	0	0	0 118	R	30	30	10 121	Y	30	30	5 128	T	0	0	0 138	K	15	15	10 138	A	15	15	10 138	D	0	0	0 140	S	30	30	10 140	A	30	30	10 140	C	30	30	10 143	C	60	10	0 143	R	60	10	0 143	H	60	10	0 143	KSGA	60	10	0 145	S	0	60	0 146	P	0	60	0 147	G	0	60	0 148	H	60	60	20 148	K	60	60	20 148	R	60	60	20 151	I	0	0	0 151	A	15	30	0 151	L	30	60	15 153	Y	0	15	10 153	F	0	10	10 155	H	60	60	10 155	S	30	30	0 155	T	30	30	0 157	Q	15	15	0 163	R	15	15	0 163	K	15	15	0 230	R	15	15	0 263	K	15	30	15

Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).

Genotype-treatment correlation

Mutation frequency according to subtype and drug-class experience.

The frequency of each mutation at position 151 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

Pos	WT	INI Naive Persons								INI Treated Persons
Pos	WT	A 337	B 3372	C 1116	D 138	F 222	G 151	AE 1097	AG 546	A 1	B 191	C 2	D 6	F 4	G 1	AE 1	AG 2
151	V		I ^5.7			I ^0.9	I ^0.7	I ^1.4			I ^9.7		I ¹⁷
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.

Genotype-phenotype correlation

Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 151.

Mutation pattern data is not available for V151.

A complete summary of additional in vitro susceptibility data for viruses with V151 obtained using other assays including the Antivirogram can be found here.

MARVEL on integrase mutations at position 151

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