- Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 62, 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC.
- Q151M causes intermediate/high-level resistance to AZT, ddI, d4T and ABC and low-level resistance to TDF, 3TC and FTC. In combination with mutations at the associated positions 75, 77, and 116, Q151M confers high-level resistance to AZT, ddI, d4T and ABC and intermediate-level resistance to TDF, 3TC and FTC. Q151L is an extremely rare transitional mutation that may precede the emergence of the Q151M.
Mutation | 3TC | FTC | ABC | AZT | D4T | DDI | TDF |
Q151L | 10 | 10 | 30 | 30 | 30 | 30 | 10 |
Q151M | 15 | 15 | 60 | 60 | 60 | 60 | 15 |
The frequency of each mutation at position 151 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.
Pos | WT | RTI Naive Persons | | NRTI (but no NNRTI) Treated Persons |
A 5908 | B 37839 | C 11132 | D 1662 | F 1155 | G 1327 | AE 10362 | AG 3905 | | A 286 | B 4182 | C 1225 | D 120 | F 80 | G 137 | AE 342 | AG 81 |
151 |
Q |
| | R 0.1 | H 0.1 T 0.1 K 0.1 | | | | | | M 0.4 | M 1.6 | M 0.9 | M 1.7 | | M 0.7 | M 2.7 | |
|
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151H | 0 | 0 | 85414 | 10 | 0.00 | |
Q151H | >=1 | >=0 | 38141 | 7 | 0.00 | 0.511 |
Q151H | AZT | >=0 | 473 | 0 | | |
Q151H | DDI | >=0 | 54 | 0 | | |
Q151H | D4T | >=0 | 55 | 0 | | |
Q151H | ABC | >=0 | 50 | 0 | | |
Q151H | D4T+3TC | >=0 | 4566 | 2 | 0.00 | 0.241 |
Q151H | AZT+3TC | >=0 | 3684 | 1 | 0.00 | 0.944 |
Q151H | D4T+DDI | >=0 | 478 | 0 | | |
Q151H | AZT+DDI | >=0 | 724 | 0 | | |
Q151H | ABC+3TC | >=0 | 601 | 1 | 0.10 | 0.126 |
Q151H | TDF+3TC | >=0 | 2511 | 0 | | |
Q151H | TDF+FTC | >=0 | 1305 | 1 | 0.00 | 0.408 |
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151K | 0 | 0 | 85414 | 10 | 0.00 | |
Q151K | >=1 | >=0 | 38141 | 7 | 0.00 | 0.511 |
Q151K | AZT | >=0 | 473 | 0 | | |
Q151K | DDI | >=0 | 54 | 0 | | |
Q151K | D4T | >=0 | 55 | 0 | | |
Q151K | ABC | >=0 | 50 | 0 | | |
Q151K | D4T+3TC | >=0 | 4566 | 6 | 0.10 | 0.000 |
Q151K | AZT+3TC | >=0 | 3684 | 4 | 0.10 | 0.000 |
Q151K | D4T+DDI | >=0 | 478 | 2 | 0.40 | 0.000 |
Q151K | AZT+DDI | >=0 | 724 | 0 | | |
Q151K | ABC+3TC | >=0 | 601 | 0 | | |
Q151K | TDF+3TC | >=0 | 2511 | 1 | 0.00 | 0.737 |
Q151K | TDF+FTC | >=0 | 1305 | 0 | | |
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151L | 0 | 0 | 85414 | 5 | 0.00 | |
Q151L | >=1 | >=0 | 38141 | 29 | 0.00 | 0.000 |
Q151L | AZT | >=0 | 473 | 0 | | |
Q151L | DDI | >=0 | 54 | 0 | | |
Q151L | D4T | >=0 | 55 | 0 | | |
Q151L | ABC | >=0 | 50 | 0 | | |
Q151L | D4T+3TC | >=0 | 4566 | 6 | 0.10 | 0.000 |
Q151L | AZT+3TC | >=0 | 3684 | 4 | 0.10 | 0.000 |
Q151L | D4T+DDI | >=0 | 478 | 3 | 0.60 | 0.000 |
Q151L | AZT+DDI | >=0 | 724 | 1 | 0.10 | 0.044 |
Q151L | ABC+3TC | >=0 | 601 | 0 | | |
Q151L | TDF+3TC | >=0 | 2511 | 2 | 0.00 | 0.003 |
Q151L | TDF+FTC | >=0 | 1305 | 0 | | |
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151M | 0 | 0 | 85414 | 1 | 0.00 | |
Q151M | >=1 | >=0 | 38141 | 919 | 2.40 | 0.000 |
Q151M | AZT | >=0 | 473 | 0 | | |
Q151M | DDI | >=0 | 54 | 0 | | |
Q151M | D4T | >=0 | 55 | 1 | 1.80 | 0.000 |
Q151M | ABC | >=0 | 50 | 1 | 2.00 | 0.000 |
Q151M | D4T+3TC | >=0 | 4566 | 154 | 3.30 | 0.000 |
Q151M | AZT+3TC | >=0 | 3684 | 27 | 0.70 | 0.000 |
Q151M | D4T+DDI | >=0 | 478 | 26 | 5.40 | 0.000 |
Q151M | AZT+DDI | >=0 | 724 | 17 | 2.30 | 0.000 |
Q151M | ABC+3TC | >=0 | 601 | 4 | 0.60 | 0.000 |
Q151M | TDF+3TC | >=0 | 2511 | 12 | 0.40 | 0.000 |
Q151M | TDF+FTC | >=0 | 1305 | 2 | 0.10 | 0.000 |
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151P | 0 | 0 | 85414 | 12 | 0.00 | |
Q151P | >=1 | >=0 | 38141 | 6 | 0.00 | 0.975 |
Q151P | AZT | >=0 | 473 | 0 | | |
Q151P | DDI | >=0 | 54 | 0 | | |
Q151P | D4T | >=0 | 55 | 0 | | |
Q151P | ABC | >=0 | 50 | 0 | | |
Q151P | D4T+3TC | >=0 | 4566 | 0 | | |
Q151P | AZT+3TC | >=0 | 3684 | 1 | 0.00 | 0.956 |
Q151P | D4T+DDI | >=0 | 478 | 0 | | |
Q151P | AZT+DDI | >=0 | 724 | 2 | 0.20 | 0.000 |
Q151P | ABC+3TC | >=0 | 601 | 0 | | |
Q151P | TDF+3TC | >=0 | 2511 | 0 | | |
Q151P | TDF+FTC | >=0 | 1305 | 0 | | |
Mutation | NRTI | NNRTI | NumSeq | NumMut | % Mutant | p |
Q151R | 0 | 0 | 85414 | 37 | 0.00 | |
Q151R | >=1 | >=0 | 38141 | 15 | 0.00 | 0.869 |
Q151R | AZT | >=0 | 473 | 0 | | |
Q151R | DDI | >=0 | 54 | 0 | | |
Q151R | D4T | >=0 | 55 | 0 | | |
Q151R | ABC | >=0 | 50 | 0 | | |
Q151R | D4T+3TC | >=0 | 4566 | 2 | 0.00 | 0.727 |
Q151R | AZT+3TC | >=0 | 3684 | 0 | | |
Q151R | D4T+DDI | >=0 | 478 | 0 | | |
Q151R | AZT+DDI | >=0 | 724 | 1 | 0.10 | 0.748 |
Q151R | ABC+3TC | >=0 | 601 | 0 | | |
Q151R | TDF+3TC | >=0 | 2511 | 0 | | |
Q151R | TDF+FTC | >=0 | 1305 | 1 | 0.00 | 0.924 | Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.
A complete summary of additional in vitro susceptibility data for viruses with Q151 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with Q151 (not just the top 10 most frequent patterns) can be found at this page.
Mutation Patterns | Number of Sequences | AZT foldn | TDF foldn | ABC foldn | 3TC foldn |
151M,184V | 190 | 1264 | 0.82 | 213 | 2004 |
151M | 142 | 7.010 | 1.09 | 5.510 | 3.016 |
115F,151M,184V | 97 | 7862 | 1.92 | 202 | 2003 |
65R,151M | 89 | 1013 | 4.93 | 182 | 363 |
65R,151M,184V | 66 | | | | |
65R,70R,151M | 40 | | | | |
65R,115F,151M,184V | 39 | 9851 | 7.51 | | 1001 |
67N,151M,184V | 29 | 4.62 | 0.31 | 8.52 | 2003 |
151M,184I | 22 | | | | |
65R,70R,115F,151M | 22 | 24001 | 111 | 201 | 891 | |
 | Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006. | | |