MARVEL on integrase mutations at position 145
HIVdb Algorithm: Comments & Scores
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes). Genotype-treatment correlation Mutation frequency according to subtype and drug-class experience. The frequency of each mutation at position 145 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.
Genotype-phenotype correlation Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 145. Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation. A complete summary of additional in vitro susceptibility data for viruses with P145 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with P145 (not just the top 10 most frequent patterns) can be found at this page.
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Footnote: Mutation patterns were defined by the presence or absence of