Mutation ARV - Evidence

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MARVEL on integrase mutations at position 145

HIVdb Algorithm: Comments & Scores

P145S is a rare nonpolymorphic mutation that has been selected in vitro by EVG and rarely in patients receiving EVG. It causes high-level resistance to EVG but not to RAL or DTG.

Mutation	RAL	EVG	DTG 51	Y	15	15	10 66	I	15	60	0 66	A	15	60	0 66	K	60	60	10 68	V	0	0	0 74	M	10	10	5 92	Q	30	60	10 92	V	30	60	5 92	G	15	30	5 95	K	10	10	0 97	A	15	10	5 114	Y	0	0	0 118	R	30	30	10 121	Y	30	30	5 128	T	0	0	0 138	K	15	15	10 138	A	15	15	10 138	D	0	0	0 140	S	30	30	10 140	A	30	30	10 140	C	30	30	10 143	C	60	10	0 143	R	60	10	0 143	H	60	10	0 143	KSGA	60	10	0 145	S	0	60	0 146	P	0	60	0 147	G	0	60	0 148	H	60	60	20 148	K	60	60	20 148	R	60	60	20 151	I	0	0	0 151	A	15	30	0 151	L	30	60	15 153	Y	0	15	10 153	F	0	10	10 155	H	60	60	10 155	S	30	30	0 155	T	30	30	0 157	Q	15	15	0 163	R	15	15	0 163	K	15	15	0 230	R	15	15	0 263	K	15	30	15

Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).

Genotype-treatment correlation

Mutation frequency according to subtype and drug-class experience.

The frequency of each mutation at position 145 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

Pos	WT	INI Naive Persons								INI Treated Persons
Pos	WT	A 337	B 3840	C 1154	D 138	F 228	G 152	AE 1121	AG 548	A 1	B 191	C 2	D 6	F 4	G 1	AE 1	AG 2
145	P
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.

Genotype-phenotype correlation

Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 145.

Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.

A complete summary of additional in vitro susceptibility data for viruses with P145 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with P145 (not just the top 10 most frequent patterns) can be found at this page.

Mutation Patterns	Number of Sequences	RAL fold_n	EVG fold_n	DTG fold_n
145S	2
Footnote: Mutation patterns were defined by the presence or absence of major INI drug resistance mutations ; Sequences containing a mixture at a major drug resistance positions were excluded; For the cutoffs defined by PhenoSense, open the sample report form provided on this page; The full list of all mutation patterns are also available here.

MARVEL on integrase mutations at position 145

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