<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 138


HIVdb Algorithm: Comments & Scores
  • E138D is a polymorphism that occurs in 1% to 2% of viruses from INI-naive patients. It does not appear to be selected by INIs or to reduce INI susceptibility.
  • E138K/A are nonpolymorphic accessory resistance mutations selected in patients receiving RAL, EVG, and DTG. They usually occur in combination with Q148 mutations. Alone they do not reduce INI susceptibility. However they are associated with >100-fold reduction in RAL and EVG susceptibility and up to 10-fold reduced DTG susceptibility when they occur in combination with Q148 mutations.

MutationRALEVGDTG 51Y151510 66I15600 66A15600 66K606010 68V000 74M10105 92Q306010 92V30605 92G15305 95K10100 97A15105 114Y000 118R303010 121Y30305 128T000 138K151510 138A151510 138D000 140S303010 140A303010 140C303010 143C60100 143R60100 143H60100 143KSGA60100 145S0600 146P0600 147G0600 148H606020 148K606020 148R606020 151I000 151A15300 151L306015 153Y01510 153F01010 155H606010 155S30300 155T30300 157Q15150 163R15150 163K15150 230R15150 263K153015
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 138 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
337
B
3372
C
1116
D
138
F
222
G
151
AE
1097
AG
546
 
A
1
B
191
C
2
D
6
F
4
G
1
AE
1
AG
2
138 E  D 0.6  D 2.2 D 1.4      A 2.7
K 2.1
D 1.1
      
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 138.
Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.

A complete summary of additional in vitro susceptibility data for viruses with E138 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with E138 (not just the top 10 most frequent patterns) can be found at this page.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
138K80.920.62 
138A,140S,148H6   
138A5   
138K,147G,148R43421652 
138K,140S,148H2   
138A,140S,143H,148H2   
Footnote: Mutation patterns were defined by the presence or absence of major INI drug resistance mutations ; Sequences containing a mixture at a major drug resistance positions were excluded; For the cutoffs defined by PhenoSense, open the sample report form provided on this page; The full list of all mutation patterns are also available here.