<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 125


HIVdb Algorithm: Comments & Scores

MutationRALEVGDTG
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 125 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
337
B
3909
C
1155
D
138
F
228
G
153
AE
1119
AG
549
 
A
1
B
275
C
2
D
7
F
12
G
1
AE
1
AG
2
125 T A 92
S 1.2
V 0.9
A 26
V 3.7
S 2.9
M 0.8
A 81
V 1.2
Q 0.5
A 58
V 1.5
S 0.7
P 0.7
A 60
V 21
M 0.9
A 83
V 2.0
K 0.7
A 98 A 91
V 1.3
S 0.7
 A 100 A 27
V 4.0
M 0.7
A 50 A 71 A 75 A 100 A 100 A 100
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 125.
Mutation pattern data is not available for T125.

A complete summary of additional in vitro susceptibility data for viruses with T125 obtained using other assays including the Antivirogram can be found here.