<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 118


HIVdb Algorithm: Comments & Scores
  • V118I is a polymorphic accessory NRTI-resistance mutation that occurs in combination with multiple TAMs.

Mutation3TCFTCABCAZTD4TDDITDF
V118I0000000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 118 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
5908
B
37839
C
11132
D
1662
F
1155
G
1327
AE
10362
AG
3905
 
A
286
B
4182
C
1225
D
120
F
80
G
137
AE
342
AG
81
118 V I 2.0 I 3.9 I 2.5
C 0.1
I 3.1
M 0.1
I 2.8 I 1.9
M 0.1
I 3.2 I 0.7  I 2.6 I 11 I 4.8 I 9.6 I 5.5 I 2.3 I 10
C 0.3
I 3.8
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
V118A0080302140.00 
V118A>=1>=038166120.000.190
V118AAZT>=04730  
V118ADDI>=0540  
V118AD4T>=0550  
V118AABC>=0500  
V118AD4T+3TC>=0456750.100.000
V118AAZT+3TC>=036860  
V118AD4T+DDI>=04790  
V118AAZT+DDI>=07240  
V118AABC+3TC>=06010  
V118ATDF+3TC>=0251110.000.944
V118ATDF+FTC>=013050  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118C0080302130.00 
V118C>=1>=038166110.000.227
V118CAZT>=04730  
V118CDDI>=0540  
V118CD4T>=0550  
V118CABC>=0500  
V118CD4T+3TC>=0456730.000.069
V118CAZT+3TC>=0368630.000.028
V118CD4T+DDI>=04790  
V118CAZT+DDI>=07240  
V118CABC+3TC>=06010  
V118CTDF+3TC>=0251110.000.906
V118CTDF+FTC>=013050  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118F008030270.00 
V118F>=1>=03816670.000.255
V118FAZT>=04730  
V118FDDI>=0540  
V118FD4T>=0550  
V118FABC>=0500  
V118FD4T+3TC>=0456730.000.006
V118FAZT+3TC>=036860  
V118FD4T+DDI>=04790  
V118FAZT+DDI>=072410.100.107
V118FABC+3TC>=06010  
V118FTDF+3TC>=025110  
V118FTDF+FTC>=0130510.000.294
MutationNRTINNRTINumSeqNumMut% Mutantp
V118G008030280.00 
V118G>=1>=03816690.000.117
V118GAZT>=04730  
V118GDDI>=0540  
V118GD4T>=0550  
V118GABC>=0500  
V118GD4T+3TC>=0456710.000.975
V118GAZT+3TC>=036860  
V118GD4T+DDI>=04790  
V118GAZT+DDI>=07240  
V118GABC+3TC>=06010  
V118GTDF+3TC>=025110  
V118GTDF+FTC>=013050  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118I008030227283.30 
V118I>=1>=038166519513.600.000
V118IAZT>=0473132.700.516
V118IDDI>=05423.700.802
V118ID4T>=05511.800.784
V118IABC>=05036.000.532
V118ID4T+3TC>=045672435.300.000
V118IAZT+3TC>=036861514.000.025
V118ID4T+DDI>=04794910.200.000
V118IAZT+DDI>=07249112.500.000
V118IABC+3TC>=0601274.400.173
V118ITDF+3TC>=025111104.300.009
V118ITDF+FTC>=01305443.300.975
MutationNRTINNRTINumSeqNumMut% Mutantp
V118M0080302130.00 
V118M>=1>=038166150.000.027
V118MAZT>=04730  
V118MDDI>=0540  
V118MD4T>=0550  
V118MABC>=0500  
V118MD4T+3TC>=0456730.000.069
V118MAZT+3TC>=0368610.000.882
V118MD4T+DDI>=04790  
V118MAZT+DDI>=07240  
V118MABC+3TC>=06010  
V118MTDF+3TC>=0251130.100.003
V118MTDF+FTC>=0130510.000.556
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 118.
Mutation pattern data is not available for V118.

A complete summary of additional in vitro susceptibility data for viruses with V118 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.