<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 118


HIVdb Algorithm: Comments & Scores
  • V118I is a polymorphic accessory NRTI-resistance mutation that occurs in combination with multiple TAMs.

Mutation3TCFTCABCAZTD4TDDITDF
V118I0000000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 118 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
5936
B
37469
C
11094
D
1841
F
1178
G
1357
AE
10347
AG
3856
 
A
282
B
4166
C
891
D
128
F
82
G
138
AE
340
AG
79
118 V I 2.0 I 3.9 I 2.5
C 0.1
I 3.2
M 0.2
I 2.7 I 1.9
M 0.1
I 3.2 I 0.7  I 2.3 I 11 I 3.8 I 9.7 I 6.7 I 2.3 I 11
C 0.3
I 3.8
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
V118A0074186140.00 
V118A>=1>=033873120.000.157
V118AAZT>=04540  
V118ADDI>=0530  
V118AD4T>=0550  
V118AABC>=0480  
V118AD4T+3TC>=0414850.100.000
V118AAZT+3TC>=033030  
V118AD4T+DDI>=04740  
V118AAZT+DDI>=06930  
V118AABC+3TC>=04110  
V118ATDF+3TC>=0136610.000.657
V118ATDF+FTC>=05330  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118C0074186110.00 
V118C>=1>=033873110.000.098
V118CAZT>=04540  
V118CDDI>=0530  
V118CD4T>=0550  
V118CABC>=0480  
V118CD4T+3TC>=0414830.000.036
V118CAZT+3TC>=0330330.000.012
V118CD4T+DDI>=04740  
V118CAZT+DDI>=06930  
V118CABC+3TC>=04110  
V118CTDF+3TC>=013660  
V118CTDF+FTC>=05330  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118F007418670.00 
V118F>=1>=03387370.000.224
V118FAZT>=04540  
V118FDDI>=0530  
V118FD4T>=0550  
V118FABC>=0480  
V118FD4T+3TC>=0414830.000.005
V118FAZT+3TC>=033030  
V118FD4T+DDI>=04740  
V118FAZT+DDI>=06930  
V118FABC+3TC>=04110  
V118FTDF+3TC>=013660  
V118FTDF+FTC>=053310.100.063
MutationNRTINNRTINumSeqNumMut% Mutantp
V118G007418660.00 
V118G>=1>=03387380.000.073
V118GAZT>=04540  
V118GDDI>=0530  
V118GD4T>=0550  
V118GABC>=0480  
V118GD4T+3TC>=0414810.000.827
V118GAZT+3TC>=033030  
V118GD4T+DDI>=04740  
V118GAZT+DDI>=06930  
V118GABC+3TC>=04110  
V118GTDF+3TC>=013660  
V118GTDF+FTC>=05330  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118I007418624853.30 
V118I>=1>=033873493014.500.000
V118IAZT>=0454122.600.482
V118IDDI>=05323.700.834
V118ID4T>=05511.800.797
V118IABC>=04836.200.475
V118ID4T+3TC>=041482205.300.000
V118IAZT+3TC>=033031273.800.135
V118ID4T+DDI>=0474479.900.000
V118IAZT+DDI>=06938812.600.000
V118IABC+3TC>=0411225.300.035
V118ITDF+3TC>=01366564.000.148
V118ITDF+FTC>=0533142.600.421
MutationNRTINNRTINumSeqNumMut% Mutantp
V118M0074186120.00 
V118M>=1>=033873140.000.024
V118MAZT>=04540  
V118MDDI>=0530  
V118MD4T>=0550  
V118MABC>=0480  
V118MD4T+3TC>=0414820.000.365
V118MAZT+3TC>=033030  
V118MD4T+DDI>=04740  
V118MAZT+DDI>=06930  
V118MABC+3TC>=04110  
V118MTDF+3TC>=0136610.000.581
V118MTDF+FTC>=05330  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 118.
Mutation pattern data is not available for V118.

A complete summary of additional in vitro susceptibility data for viruses with V118 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.