<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 118


HIVdb Algorithm: Comments & Scores
  • V118I is a polymorphic accessory NRTI-resistance mutation that occurs in combination with multiple TAMs.

Mutation3TCFTCABCAZTD4TDDITDF
V118I0000000
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 118 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
4192
B
27421
C
8709
D
1603
F
728
G
1593
AE
5640
AG
2957
 
A
205
B
4133
C
551
D
127
F
82
G
146
AE
325
AG
78
118 V I 1.8 I 3.0 I 2.5 I 3.2 I 2.8 I 1.5 I 1.8 I 0.8  I 2.1 I 11 I 5.2 I 11 I 6.7 I 2.1 I 11 I 5.2
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
V118A0050974130.00 
V118A>=1>=02545580.000.815
V118AAZT>=04530  
V118ADDI>=0530  
V118AD4T>=0550  
V118AABC>=0470  
V118AD4T+3TC>=0327040.100.012
V118AAZT+3TC>=023010  
V118AD4T+DDI>=04660  
V118AAZT+DDI>=05780  
V118AABC+3TC>=02850  
V118ATDF+3TC>=03680  
V118ATDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118C005097460.00 
V118C>=1>=02545590.000.055
V118CAZT>=04530  
V118CDDI>=0530  
V118CD4T>=0550  
V118CABC>=0470  
V118CD4T+3TC>=0327030.000.006
V118CAZT+3TC>=0230130.100.001
V118CD4T+DDI>=04660  
V118CAZT+DDI>=05780  
V118CABC+3TC>=02850  
V118CTDF+3TC>=03680  
V118CTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118G005097460.00 
V118G>=1>=02545570.000.202
V118GAZT>=04530  
V118GDDI>=0530  
V118GD4T>=0550  
V118GABC>=0470  
V118GD4T+3TC>=032700  
V118GAZT+3TC>=023010  
V118GD4T+DDI>=04660  
V118GAZT+DDI>=05780  
V118GABC+3TC>=02850  
V118GTDF+3TC>=03680  
V118GTDF+FTC>=03520  
MutationNRTINNRTINumSeqNumMut% Mutantp
V118I005097414492.80 
V118I>=1>=025455413116.200.000
V118IAZT>=0453122.600.916
V118IDDI>=05323.701.000
V118ID4T>=05511.800.956
V118IABC>=04736.300.308
V118ID4T+3TC>=032701665.000.000
V118IAZT+3TC>=02301944.000.001
V118ID4T+DDI>=04664710.000.000
V118IAZT+DDI>=05788614.800.000
V118IABC+3TC>=0285165.600.009
V118ITDF+3TC>=0368123.200.746
V118ITDF+FTC>=035271.900.423
MutationNRTINNRTINumSeqNumMut% Mutantp
V118M005097470.00 
V118M>=1>=02545590.000.093
V118MAZT>=04530  
V118MDDI>=0530  
V118MD4T>=0550  
V118MABC>=0470  
V118MD4T+3TC>=0327020.000.180
V118MAZT+3TC>=023010  
V118MD4T+DDI>=04660  
V118MAZT+DDI>=05780  
V118MABC+3TC>=02850  
V118MTDF+3TC>=036810.200.064
V118MTDF+FTC>=03520  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 118.
Mutation pattern data is not available for V118.

A complete summary of additional in vitro susceptibility data for viruses with V118 obtained using other assays including the Antivirogram can be found here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.