<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on RT mutations at position 115


HIVdb Algorithm: Comments & Scores
  • Y115F causes intermediate-level resistance to ABC and low-level resistance to TDF.

Mutation3TCFTCABCAZTD4TDDITDF
Y115F004500015
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 115 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTRTI Naive Persons NRTI (but no NNRTI) Treated Persons
A
5936
B
37469
C
11094
D
1841
F
1178
G
1357
AE
10347
AG
3856
 
A
282
B
4166
C
891
D
128
F
82
G
138
AE
340
AG
79
115 Y      N 0.1    F 0.7 F 0.8 F 0.9    F 1.2  
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Mutation frequency according to treatment with individual ARVs.
The first row shows the frequency of the mutation in persons who are RTI-naive (indicated in green). The second row shows the frequency of the mutation in persons who have received one or more NRTIs (+/- NNRTIs). The following rows show the frequency of the mutation in persons who have received only a single NRTI. Mutation rates that differ significantly between treated and untreated isolates are indicated in yellow.
MutationNRTINNRTINumSeqNumMut% Mutantp
Y115F007975160.00 
Y115F>=1>=03387610052.900.000
Y115FAZT>=04540  
Y115FDDI>=0530  
Y115FD4T>=0550  
Y115FABC>=04848.300.000
Y115FD4T+3TC>=04147220.500.000
Y115FAZT+3TC>=03303130.300.000
Y115FD4T+DDI>=047430.600.000
Y115FAZT+DDI>=069481.100.000
Y115FABC+3TC>=04118520.600.000
Y115FTDF+3TC>=0136618213.300.000
Y115FTDF+FTC>=0533407.500.000
MutationNRTINNRTINumSeqNumMut% Mutantp
Y115H0079751100.00 
Y115H>=1>=03387680.000.272
Y115HAZT>=04540  
Y115HDDI>=0530  
Y115HD4T>=0550  
Y115HABC>=0480  
Y115HD4T+3TC>=0414710.000.950
Y115HAZT+3TC>=033030  
Y115HD4T+DDI>=04740  
Y115HAZT+DDI>=06940  
Y115HABC+3TC>=041110.200.061
Y115HTDF+3TC>=013660  
Y115HTDF+FTC>=05330  
MutationNRTINNRTINumSeqNumMut% Mutantp
Y115N007975180.00 
Y115N>=1>=03387660.000.439
Y115NAZT>=04540  
Y115NDDI>=0530  
Y115ND4T>=0550  
Y115NABC>=0480  
Y115ND4T+3TC>=041470  
Y115NAZT+3TC>=0330310.000.808
Y115ND4T+DDI>=04740  
Y115NAZT+DDI>=06940  
Y115NABC+3TC>=04110  
Y115NTDF+3TC>=013660  
Y115NTDF+FTC>=05330  
Footnote: About one-half of the untreated isolates belong to non-subtype B isolates; About 20% of the treated isolates belong to non-subtype B isolates; A page containing summaries for all of the mutations at this position can be found here.

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 115.
Mutation patterns are listed in the frequency with which they have been reported in the published literature. The median level of fold resistance (compared with wildtype) for viruses with the mutation pattern in the first column are indicated when available. The subscripts indicate the number of viruses that were phenotyped. The drug susceptibility assay used was the PhenoSense assay (Monogram, South San Francisco). A hyperlink for each individual pattern is provided to access a complete list of mutations and fold resistances for each sequence matching the pattern of mutation.

A complete summary of additional in vitro susceptibility data for viruses with Y115 obtained using other assays including the Antivirogram can be found here. A complete list of all mutation patterns with Y115 (not just the top 10 most frequent patterns) can be found at this page.

Mutation PatternsNumber of
Sequences
AZT
foldn
TDF
foldn
ABC
foldn
3TC
foldn
74V,115F,184V2410.440.641732006
65R,115F,184V207    
115F,151M,184V9278621.922022003
65R,115F820.321.825.822003
115F,184V600.730.931132005
65R,115F,151M,184V3798517.51 1001
70E,115F,184V310.210.9110.012002
65R,74I,115F,184V31    
65R,70R,115F,151M2224001111201891
65R,74V,115F,184V21    
Footnote: Mutation patterns were defined by the presence or absence of major NRTI drug resistance mutations ; Sequences containing a mixture at a major drug resistance positions were excluded; For the cutoffs defined by PhenoSense, open the sample report form provided on this page; The full list of all mutation patterns are also available here.

 

Phenotypic coefficients using machine learning
Least Square Regression (LSR) was used to learn the relative contribution of each mutation to the fold decrease in susceptibility for an ARV. The figure on the left (click to enlarge the figure) shows the regression coefficients (which correlate with the contribution to resistance) for the 23 nonpolymorphic NRTI-resistance mutations shown to contribute decreased susceptibility to at least one NRTI. A complete description of the method that generates this figure can be found at Rhee et al PNAS 2006.