<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation L89M
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 148
Isolates 156
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2000)AH-HC14HolgHC14AF125294SQV, RTV   I13V, K14R, I15L, L19P, K20I, E21K, E35D, M36I, R41K, H69K, L89MG
Thomson (2001)MT-X397MT-X397AY017461IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
Cuevas (2002)CU87CU87AF425468IDV   I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 CU72CU72AF425453IDV   I13V, K20I, E35D, M36I, R41K, L63Q, I64L, H69K, V82I, L89MG
Holguin (2003)SP_LP17SP_LP17AF455614PINA  L10I, I13V, K14R, E35D, M36I, R41K, H69K, L89MG
 SP_LP40SP_LP40AF455631PINA  I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89MG
Monno (2003)ML_Pat49ML_Pat49 PINA  L10LI, T12TK, I13V, K14R, G17GE, K20I, M36I, R41K, L63S, C67Y, H69K, K70KR, V82I, L89MG
Montes (2004)MB_patMAS D01_MASD709AJ577944NFV8  L10I, I13V, K14Q, L19P, K20I, M36I, R41K, L63P, C67Y, H69K, L89MG
 MB_patVIG02_VIG701AJ578178SQV, RTV, IDV252M46I, I54A, V82T L10I, I13V, K14R, K20I, E35N, M36I, N37D, R41K, Q61H, L63P, C67E, H69K, I72V, T74S, L89MG
 MB_patHEN01_HEN734AJ577913NFV, LPV62I54V, L90M I13V, K20I, E35G, M36I, R41K, H69K, K70R, V82I, L89MG
 MB_patRAM02_RAM705AJ577980Unknown, RTV, IDV>120M46L, G48V, I54V, V82T L10V, I13V, K20I, M36I, N37D, R41K, I66F, H69K, K70R, L89MG
 MB_patVERD00_VERD709AJ578173SQV, IDV, NFV102  T12K, I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 MB_patDEL01_DEL725AJ577879IDV, RTV21  I13V, K14R, K20I, E35D, M36I, R41K, K45R, R57K, L63S, C67E, H69K, V82I, L89MG
  02_DEL707AJ577880IDV, RTV, Unknown>21  I13V, K14R, K20I, E35D, M36I, R41K, K45R, R57K, L63S, I64M, C67E, H69K, V82I, L89MG
Non-B Workgroup (2005)IL263IL263AY900819IDV, LPV90M46IL, V82VAL24IW6WR, R8RQ, L10LI, I13V, K20I, M36I, R41K, C67E, H69K, L89MG
 PL3402555105 IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3410555285 RTV, IDV, Unknown>103  I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL40555413 SQV, NFV, IDV L90LM I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, V82I, L89MG
 PL3200255557AY900704NFV, RTV   I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89MG
 PL3429355694 NFV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3435855823AY900705IDV108M46MI, V82T L10LI, I13V, K14R, K20I, E35D, M36I, R41K, I64IM, C67E, H69K, K70R, T74TS, L89MG
 PL1495255878 SQV   I13V, K14R, K20I, E35D, M36I, R41K, K55N, H69K, V82I, L89MG
 PL3463956456 IDV   I13V, K20I, E35D, M36I, R41K, H69K, V77VI, V82I, L89MG
 PL1268056667AY900712NFV, RTV, IDV I54IV L10LI, I13V, K14R, K20I, E35D, M36I, R41K, I66IF, H69K, V82I, L89MG
 PL1708257141AY900715IDV30M46I, V82S I13V, K20I, E35D, M36I, R41K, K45R, L63P, I66F, H69K, K70R, L89MG
 PL3509657407 IDV   W6W*, I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL1797558686 IDV   I3IL, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, H69K, V82I, L89MG
 PL3466856513 RTV, IDV   I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL2456659094AY900975SQV, RTV   I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3516757581AY900979IDV, RTV47I54VL24II13V, K14R, K20I, E35D, M36I, N37K, R41K, L63P, H69K, V82I, L89MG
 PL3597559300 IDV   I13V, K14R, K20I, M36I, R41K, H69K, V82I, L89MG
 PL2528860799 SQV, IDV, RTV   I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3349961173AY900986IDV, NFV   I13V, K14R, K20I, E35D, M36I, R41K, C67CG, H69K, V82I, L89MG
 PL3679961175AY900988NFV M46MI, I54IV, N88NS, L90LM I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82VI, L89MG
 PL3679461169 SQV52  I13V, K14R, K20I, E35DN, M36I, R41K, H69K, V82I, L89MG
 PL3707461791AY900989IDV M46L, I54V I13V, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, K70R, V82I, L89MG
 PL1618161896 IDV, SQV134  I13V, K14KR, I15IV, K20I, E35N, M36I, R41K, H69K, I72T, V82I, L89MG
 PL887561905AY900995IDV M46I, I54V, V82T, I84VQ58EL10I, I13V, K20I, E35D, M36I, R41K, L63P, I66F, H69K, A71AV, T74K, L89MG
 PL3713161948 IDV139  I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3679561171AY900999NFV L90M L10I, I13V, K14R, K20I, E35D, M36I, R41K, R57K, H69K, V82I, L89MG
 PL1435061920 IDV   I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL848862141AY901000SQV, RTV, IDV182  P1PS, T4X, I13V, K14R, K20I, M36I, R41K, H69K, V82I, L89MG
 PL3228062845 IDV   I13V, K14R, K20I, E35D, M36I, G40R, R41K, H69K, V82I, L89MG
 PL3381162357AY901008NFV   L10LI, T12TA, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, L63LP, H69K, A71DN, V82I, L89MG
 PL2529062869AY901010SQV L90M I13V, K20I, E35D, M36I, N37NS, R41K, L63P, H69K, K70R, A71AV, V82I, L89MG
 PL1732162353 IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3777363321 IDV, RTV   I13V, K20I, E35D, M36I, R41K, H69K, I72V, V82I, L89MG
 PL3749262771AY901017NFV  L33LIT12TK, I13V, K20I, E35D, M36I, R41K, R57RK, L63H, H69K, I72T, V82I, L89MG
  96995 NFV, UnknownNA  I13V, K14KR, K20I, E35D, M36I, R41K, R57K, L63H, H69K, K70KR, I72T, V82I, L89MG
 PL2761564190 IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3701164192 IDV   I13V, K14R, K20I, E35D, M36I, R41K, R57K, H69K, V82I, L89MG
 PL3780863405AY901023NFV   I13V, K20I, M36I, N37I, R41K, H69K, V82I, L89MG
 PL3142163409AY901024IDV, APV, LPV   I13V, K14R, K20I, E35D, M36I, R41K, L63P, C67E, H69K, V82I, L89MG
 PL3796663734 IDV   I13V, K14KR, I15V, K20I, E35D, M36I, R41K, L63P, H69K, V82I, L89M, I93LG
 PL2444063889 IDV, RTV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3814564117AY901026SQV, IDV238M46I, I54V, V82T, I84V L10I, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63P, I66F, H69K, K70R, L89MG
 PL3844864783AY901029NFV L90M I13V, K14R, K20I, E35EG, M36I, R41K, D60E, L63P, H69K, T74S, V82I, L89M, I93LG
 PL3835182869 NFV, UnknownNA  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3799563787 IDV   I13V, K14KR, L19LS, K20I, E35D, M36I, N37ND, R41K, H69K, V82I, L89MG
 PL2341264116AY901033IDV, RTV, LPV   T12TA, I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL192064065 NFV L90LM I13V, K14R, K20I, M36I, R41K, H69K, V82I, L89MG
 PL3865465227AY901038IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89MG
 PL943966213 IDV, SQV, NFV, RTV   I13V, K14KR, K20I, E35D, M36I, R41K, L63LP, H69K, V82I, L89MG
 PL2012664874 NFV, IDV   I13V, L19I, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3865565229 NFV, IDV, RTV L90M I13V, K20I, E35N, M36I, R41K, L63C, H69K, V82I, L89MG
 PL3899466003 RTV, IDV29  W6G, I13V, L19R, K20N, E35EG, M36I, R41K, H69K, V82I, L89MG
 PL887866214 IDV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89MG
 PL3912766261 NFV   I13V, K14R, K20I, E35D, M36I, R41K, R57K, H69K, V82I, L89MG
 PL3892965866AY901047IDV, RTV   I13V, K20I, E35ED, M36I, R41K, H69K, V82I, L89MG
 PL834365230 IDV, APV, LPV73  I13V, K14R, K20I, E35DN, M36I, R41RK, R57RK, H69K, K70KR, V82I, L89MG
 PL3261666358 NFV87  I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3419967194AY901053IDV   L10I, I13V, K14KR, K20I, E35D, M36I, R41K, R57K, H69K, V82I, L89MG
 PL846867575 RTV74I54V, L90MQ58EI13V, K14R, K20I, E35D, M36I, R41K, L63P, H69K, V82I, L89MG
 PL3993768123AY901057NFV   I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL2700868100 NFV   I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4006168372AY901060PINAN88S I13V, K14KR, I15IV, K20I, E35DN, M36I, R41K, H69K, K70KR, V82I, L89MG
 PL2499169313AY901064NFV90  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3897068858AY901066SQV, NFV, RTV, IDV I54IV, L90LM I13V, K14R, K20I, A28Q, E35D, M36I, R41K, H69KR, V82I, L89MG
 PL2552869053 IDV   I13V, K20I, E35D, M36I, R41K, Q61E, H69K, K70R, V82I, L89MG
 PL4043369148AY901071SQV, IDV91  I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL2842869742 IDV, LPV   I13V, K14R, K20I, E35D, M36I, R41K, Q61X, H69K, V82I, L89MG
 PL1932669880 NFV, IDV, RTV L90LM I13V, K14R, K20I, E35D, M36I, R41K, K43KR, R57K, L63Q, I64M, H69K, V82I, L89MG
 PL3150670211 IDV   I13AV, K14KR, I15X, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4074569862AY901093SQV, IDV, ATV   L10I, I13V, K14R, L19I, K20I, E34Q, E35ED, M36I, P39S, R41K, C67E, H69K, V77VI, L89MG
 TK2013TK2013 IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
  TK2013a IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
 PL53378101651 IDV30  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL1014683346 RTV, IDV151M46I, I54V, V82T I13V, K14R, K20I, E35D, M36I, N37ND, R41K, I62V, I66F, H69K, L89MG
 PL1141561170 IDV86  I13V, K14R, K20I, E35D, M36I, R41K, C67S, H69K, V82I, L89MG
  63407 IDV86  I13V, K14R, K20I, E35D, R41K, C67S, H69K, V82I, L89MG
 PL14163105581 IDV330I54V I13V, K20I, E35D, M36I, R41K, H69K, T74S, V82I, L89MG
 PL1920995879 NFV78  I13V, K14R, K20I, E35N, M36I, R41K, H69K, V82I, L89MG
 PL2062582016 IDV61  I13V, K20I, E35DN, M36I, R41K, H69K, V82I, L89MG
 PL2632060887 NFV171N88S I13V, K14R, K20I, E35N, M36I, R41K, I62V, I64V, H69K, T74S, V82I, L89MG
 PL2643299169 RTV, IDV17  I13V, L19I, K20I, E35D, M36I, R41K, C67S, H69K, V77I, V82I, L89MG
 PL28120100793 LPV39M46MI, I54V, L76VL24LI, Q58EL10I, I13V, K20I, E35D, M36I, R41K, L63P, H69K, V82I, L89MG
 PL30686101546 RTV, IDV251  I13V, K14R, I15V, K20I, E35D, M36I, R41K, I64IM, H69K, V82I, L89MG
 PL3145672731 RTV, IDV97  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
  89968 RTV, IDV, LPV157  I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3373076228 Unknown, RTV, IDV>80I54V, V82F L10I, I13V, K14R, K20I, E35D, M36I, R41K, K45Q, H69K, L89MG
 PL3535384332 NFV107N88S I13V, K20I, E35EG, M36I, R41K, H69K, V82I, L89MG
 PL3704676044 IDV130I54V I13V, K14R, K20I, E35D, M36I, R41K, I66IF, H69K, L89MG
 PL3805585287 NFV86  I13V, K20I, E35D, M36I, R41K, L63LH, H69K, K70KR, V82I, L89MG
 PL3857099368 NFV65  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL3932697222 RTV, IDV, LPV168I54IV I13V, K14R, K20I, E35AD, M36I, R41K, R57RK, D60DE, I62IV, L63LV, I64IM, I66IF, H69K, V82I, L89MG
 PL401093238 IDV, NFV266L90LM I13V, K14R, K20I, E35D, M36I, R41K, I64IV, H69K, I72IV, V82I, L89MG
 PL4092370238 SQV, NFV47  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
  97544 SQV, NFV, LPV129L90M I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL41580101499 IDV, Unknown>52  I13V, K14R, I15V, K20I, E35D, M36I, P39Q, R41K, H69K, V82I, L89MG
 PL4242676040 NFV82  I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, V82I, L89MG
 PL4268876257 RTV, IDV29M46I, V82T I13V, K20I, E35D, M36I, R41K, H69K, L89MG
 PL4294589964 LPV34  T12A, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4307775315 NFV224M46L, I54V, L90M I13V, K14R, L19I, K20I, E35N, M36I, R41K, K55KR, R57RK, H69K, V82I, L89MG
 PL4311375406 IDV, Unknown>52  I13V, K14R, G16GE, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4366176757 IDV204  L10I, I13V, K14R, K20I, E35D, M36I, R41K, L63P, H69K, K70R, V82I, L89M, I93IVG
 PL4410477796 SQV78  I13V, K20I, E35D, M36I, R41K, H69K, K70KR, I72IT, V82I, L89MG
 PL4423878139 IDV106M46I, I54V, V82T L10LI, I13V, K20I, E35D, M36I, R41K, I66F, H69K, L89MG
 PL4432678321 IDV263M46I, I54V, L90M I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89M, I93MG
 PL4479479470 RTV, IDV56  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4498179914 IDV77  I13V, K14R, K20I, E35D, M36I, N37D, R41K, H69K, K70R, V82I, L89MG
 PL4504180062 NFV130L90M I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL45291105157 NFV64L90ML23II13V, K20I, E35G, M36I, R41K, H69K, T74S, V82I, L89MG
 PL45525102251 SQV, RTV17  I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70KR, V82I, L89MG
 PL4586782009 IDV218I54V I13V, K14R, K20I, E35D, M36I, R41K, I64IL, H69K, V82I, L89MG
  100992 IDV277I54V I13V, K14R, K20I, E35D, M36I, R41K, I64IL, H69K, V82I, L89MG
 PL4673984133 IDV25  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL4706785003 LPV8  I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL48151104842 IDV, LPV206  L10LI, I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL48170102151 IDV39  L10I, I13V, L19LP, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89MG
 PL4935891289 IDV104  L10I, I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70KR, V82I, L89MG
 PL5039394037 IDV39  T12A, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL5133996552 NFV47  I13V, K14R, K20I, E35D, M36I, L38LF, R41K, H69K, V82I, L89MG
 PL5178697581 SQV291  I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89MG
 PL52835100333 LPV39 V11IT12TA, I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 PL54677105261 LPV142  I13V, K14R, K20I, M36I, R41K, H69K, V82I, L89MG
 PL54919106008 IDV, LPV169M46I, I54V, V82SL24IL10LIV, I13V, K14R, K20I, E35DN, M36I, R41K, L63P, H69K, L89MG
 PL881592822 NFV285  I13V, G16GE, K20I, E35D, M36I, R41K, H69K, I72IT, V82I, L89MG
 PL44976PL44976 SQV, NFV, LPV80  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
Baxter (2006)48-22312231-30609DQ877873PINA  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 48-22382238-30731DQ877877PINA  I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 48-33183318-30924DQ878218PINAG48V, I54V, V82M, L90MK43T, T74PL10V, T12TK, I13V, K20I, E35D, M36IV, N37D, R41K, Q61QH, I62V, C67E, H69K, L89MG
 48-43944394-30912DQ878533PINAM46I, I54V, L76V, V82F L10I, I13V, G16GA, K20I, E35D, M36I, L63P, H69K, T74TS, L89MG
 48-80118011-30506DQ879056PINAM46I, I50VL33F, F53LI13V, K14R, K20T, E35R, M36I, N37D, R41K, L63LP, C67E, H69K, T74A, V82I, L89MG
 48-80768076-30925DQ879086PINAM46I, I54V, L76V, I84VQ58EL10I, I13V, K14R, I15V, K20I, E35N, M36I, N37D, R57RK, D60Q, L63P, H69K, V82I, L89MG
Laurent (2006)CK2-9102CM-91AM279449IDV13  I13V, K14R, K20I, E35D, M36I, R41K, L63P, H69K, L89MG
Bradshaw (2007)pt01Pop03-2005EU099970SQV, LPV, ATV   I13V, K14R, Q18QK, K20I, M36I, R41K, C67E, H69K, V82I, L89MG
  Pop11-2005EU099971SQV, LPV, ATV   I13V, K14R, Q18QK, K20I, M36I, R41K, C67E, H69K, V82I, L89MG
Knops (2010)Pat04Pat04GU991865NFV D30NQ58E, N88DI13V, K20I, E35N, M36I, R41K, K45R, H69K, K70R, V82I, L89MG
 Pat10Pat10GU991871NFV   I13V, K14KR, K20I, E35D, M36I, N37D, R41K, H69K, K70R, V82I, L89MG
 Pat13Pat13GU991874NFV, IDV   I13V, K20I, E35D, M36I, R41K, K43R, H69K, V82I, L89MG
 Pat18Pat18GU991879IDV   T4S, I13V, K20I, E35D, M36I, R41K, K43R, C67Y, H69K, V82I, L89MG
 Pat20Pat20GU991881IDV   L10I, I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MG
 Pat21Pat21GU991882NFV, IDV L90LM I13V, K20I, E35D, M36I, R41K, H69K, V82I, I85IV, L89MG
Charpentier (2011)234CP 001 2162 Unknown, LPVNA  I13V, L19M, K20I, E35K, M36I, N37DE, R41K, K45R, C67S, H69K, V82I, L89MG
Barber (2012)6806168061JQ361672LPV I54V, L90LM I13V, K14R, K20I, E35Q, M36I, N37NDEK, R41K, I62IV, L63P, C67E, H69K, A71AV, V82I, L89M, I93IMG
Grossman (2014)18511851KF135007LPV52  I13V, K14R, K20I, E35Q, M36I, N37D, R41K, R57K, L63S, C67E, H69K, V82I, L89MG