<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 59
Isolates 63
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patHEN02_HEN716AJ577914NFV, LPV85I54V, L90MQ58EI13V, K20I, E35G, M36I, R41K, H69K, K70R, V82I, L89IG
 MB_patGRA00_GRA703AJ577905NFV, SQV, LPV107M46L, I54V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I64M, C67E, H69K, A71V, I72V, T74S, V82I, L89I, I93LG
Non-B Workgroup (2005)PL875856741AY900713SQV, RTV, IDV229G48M, I54V, V82T, L90MF53LI13V, K14R, K20I, E35D, M36I, R41K, Q61H, H69K, A71V, L89IG
 PL3476656768AY900714NFV73L90M I13V, K20I, E35N, M36I, R41K, H69K, K70R, A71T, V82I, L89IG
 PL529657203AY900717SQV, NFV, IDV I54V, V82M, L90MF53LI13A, K14R, I15V, K20I, E35D, M36I, R41K, I62IV, C67CW, H69K, T74A, L89IG
 PL3510257431AY900721SQV, NFV, IDV181I54V, L90MF53LI13V, K14KR, K20IV, L33LV, E35D, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T74S, V82I, L89IG
 PL3379057583AY900722NFV I54V, L90ML33LII13V, K14R, K20IT, E35D, M36I, N37D, R41K, H69K, V82I, L89IG
 PL1087759219AY900976IDV, SQV I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL3606959512AY900981NFV I54V, L90M I13V, K20I, E35N, M36I, N37ND, R41K, H69K, T74S, V82I, L89IG
 PL3655160625AY900985NFV L90M I13V, K14R, G17E, K20I, E35N, M36I, R41K, I62V, L63P, H69K, K70R, A71T, V82I, L89IG
 PL3694361481AY900991NFV73I54IV, L90M I13V, K14R, I15V, K20IV, E35DN, M36I, R41K, H69K, A71T, T74S, V82I, L89IG
 PL410862261AY901001NFV L90M I13V, K14R, K20I, E35EG, M36I, R41RK, H69K, A71AT, V82I, L89IG
 PL86262513AY901003IDV, ATV I54V, V82T, L90M I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71V, T74S, L89IG
 PL3729062297AY901009NFV87I54V, L90M I13V, K20T, E35D, M36I, R41K, H69K, V82I, L89IG
 PL2430163125AY901013NFV, RTV, IDV173I54V, I84V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I62IV, L63P, H69K, A71V, T74S, L89IG
 PL3820164222AY901019SQV, IDV M46MI, I54V, V82M, L90M I13AV, K14R, I15IV, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, K70R, L89IG
 PL3788763577AY901020IDV, RTV   I13V, K14R, G17E, E21K, M36I, R41K, Q58QR, L63P, H69K, K70R, V82I, L89IG
 PL2397263353AY901021NFV L90M I13V, K14R, K20I, E35X, M36I, R41K, I62IV, I64IV, I66IF, H69K, K70KR, V82I, L89I, Q92QK, I93ILG
 PL2053364517AY901032IDV, APV   I13V, K20I, M36I, R41K, L63P, C67S, H69R, I72T, V82I, L89IG
 PL2745264378AY901034SQV L90MF53LI13V, K14R, K20I, E35D, M36I, R41K, H69K, A71V, V82I, L89IG
 PL3832564508AY901035IDV87I54V, V82A L10I, I13V, K14KR, L19LS, K20I, E35D, M36I, N37D, R41K, H69K, A71IV, T74S, L89IG
 PL3857565077AY901037NFV169L90M I13V, K14R, I15V, K20IV, E35N, M36I, R41K, H69K, K70KR, A71T, V82I, L89IG
 PL1003066215AY901040SQV, IDV I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
 PL3595467123AY901045SQV, IDV, NFV I54V, L90M I13V, K14R, K20I, E35N, M36I, R41K, K45R, H69K, A71AV, V82I, L89IG
 PL3980567858AY901056NFV117I54V, L90M I13V, K14R, K20IT, E35DN, M36I, R41K, H69K, V82I, L89IG
 PL985667800AY901068NFV, RTV M46I, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, I62V, H69K, T74A, V82I, L89I, I93LG
 PL4041269106AY901069IDV117I54V, V82M, L90M I13V, K20I, E35D, M36I, R41K, L63LP, H69K, L89IG
 PL3690261392AY901077PINAL90M T12TP, I13V, K14R, I15V, K20T, E35D, M36I, R41K, H69K, K70R, A71T, T74S, V82I, L89IG
 PL3414765713AY901095NFV  L23II13V, K14R, K20I, E35G, M36I, R41K, H69K, T74S, V82I, L89I, Q92KG
 PL1003066215 SQV, IDV275I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
 PL1087759219 IDV, SQV194I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL1481477297 NFV221M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, L89I, I93MG
  78800 NFV228M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, R87E, L89I, I93MG
 PL2824476856 IDV91I54V, L90ML33LII13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89IG
 PL2909097083 IDV, NFV, SQV, RTV179M46L, G48V, I54V, V82T L10I, I13V, K14R, K20I, E35DN, M36V, R41Q, H69K, K70E, A71V, L89I, I93LG
 PL3263599822 IDV, SQV, RTV216I54V, L90MF53LI13V, K14R, L19I, K20I, E35D, M36I, R41K, L63LP, H69K, A71V, V82I, L89IG
 PL3965167522 NFV151I54V, L90M I13V, K14R, K20I, E35N, M36I, R41K, K45KR, I62IV, H69K, A71AV, T74S, V82VI, L89IG
 PL4050977525 NFV171I54IL, L90M I13V, K14R, K20T, E35D, M36I, R41K, I62IV, H69K, A71T, V82I, L89IG
 PL405467728 SQV, NFV, IDV255M46ML, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, D60DE, I62IV, H69K, T74S, V82I, L89IG
  105535 SQV, NFV, IDV267I54V, L90M I13V, K14KR, I15V, K20T, E35D, M36I, R41K, I62V, H69K, T74S, V82I, L89IG
 PL4208372851 NFV, RTV, IDV214M46I, I54V, V82F, L90M L10I, I13V, K14R, I15IV, K20I, E35D, M36V, N37ND, R41K, R57RK, D60DE, L63LP, H69K, A71AV, L89IG
 PL4236173571 RTV, IDV160M46L, G48V, I54V, V82SK43TL10I, I13A, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, T74S, L89IG
 PL4315675500 SQV, NFV281L90M I13V, K14R, I15IV, K20T, E35DN, M36I, R41K, I62IV, H69K, A71T, T74S, V82I, L89IG
 PL4356276535 SQV, IDV86I54V, V82S I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, T74S, L89IG
 PL4404477623 RTV, IDV, NFV104I54V, V82VA L10LI, I13V, K14R, K20I, E35D, M36I, R41K, L63LP, H69K, A71AV, T74S, L89IG
 PL4492479756 Unknown, LPV>82I54V, L90MF53LI13V, I15IV, K20I, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, V82I, L89I, Q92QRG
 PL45677100951 IDV43M46I, L90LM I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, L89IG
 PL5048894311 RTV, IDV84I54V, V82T, I84V, L90M I13V, K14R, I15V, K20I, E35D, M36I, R41K, C67F, H69K, A71V, L89IG
 PL5246199339 IDV178I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, R41K, I62IV, L63LP, C67W, H69K, A71V, L89IG
 PL550897431 IDV126L90M T12A, I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, V82I, L89IG
 PL717994478 RTV, IDV69  I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, K70R, V82I, L89IG
 PL865105515 SQV486I54V, L90MF53LL10I, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, L63A, H69K, A71V, T74S, V82I, L89IG
 PL1197773201 NFV36L90M I13V, K14R, I15IV, K20T, E35D, M36I, R41K, I62V, H69K, A71T, T74S, V82I, L89IG
Baxter (2006)48-12171217-30701DQ877755PINAI54V, V82A, L90MV11I, F53LL10V, T12K, I13V, K14R, G16E, K20I, L33L_L, E35D, M36I, R41K, I62V, H69K, A71V, L89IG
 48-22252225-30423DQ877867PINAM46I, I47V, I54V, V82AF53LI13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TSG
von Wyl (2007)53700437EF449874PINAI54V, L90LM I13V, K14R, K20I, L33V, E35Q, M36I, R41K, R57K, D60DE, C67E, H69K, V82I, L89IG
Knops (2010)Pat02Pat02GU991863NFV L90M I13V, K20V, E35D, M36I, N37D, G40GE, R41K, H69K, T74S, V82I, L89IG
 Pat05Pat05GU991866NFV L90M I13V, I15IV, L19LI, K20AITV, E35DG, M36I, N37ND, R41K, I62IV, L63LP, H69K, K70KR, A71T, T74TS, V82I, L89IG
 Pat07Pat07GU991868LPV M46I, I54V, L76V, V82MQ58EL10V, I13A, K20IM, A22AV, E35D, M36I, R41RK, I62IV, L63P, H69K, L89I, T91SG
 Pat08Pat08GU991869NFV, IDV, LPV M46I, I54A, V82M, L90MK43TT4A, L10I, I13V, I15V, L19P, K20I, E35S, M36I, N37E, R41K, V56A, R57K, L63P, H69K, A71V, T74S, V77I, L89I, Q92KG
 Pat14Pat14GU991875SQV, LPV M46L, G48V, I54V, V82S, L90MK43TL10I, T12K, I13V, I15V, K20I, E35N, M36I, N37D, R41K, Q61HN, L63C, C67W, H69K, T74S, L89IG
 Pat19Pat19GU991880LPV M46I, I50V, I54V, V82MV11VI, F53LL10V, T12S, I13V, I15IV, L19P, K20I, E35DN, M36I, R41K, K45V, Q61QH, I64V, C67CY, G68D, H69K, A71V, L89IG
Van Zyl (2013)18282545KC423741LPV26I54V, V82M L10I, I13V, K20I, E35Q, M36I, N37D, R41K, R57K, L63P, C67E, H69K, A71T, L89IG