<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation T74S
Rx >= 1 PI
IncludeMixtures No
References 5
Patients 41
Isolates 44
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cuevas (2002)CU75CU75AF425456SQV L90MF53L, L89VL10V, I13V, K20I, M36I, R41K, Q61E, H69K, K70R, A71V, T74SG
Montes (2004)MB_patVIG02_VIG701AJ578178SQV, RTV, IDV252M46I, I54A, V82T L10I, I13V, K14R, K20I, E35N, M36I, N37D, R41K, Q61H, L63P, C67E, H69K, I72V, T74S, L89MG
 MB_patGRA00_GRA703AJ577905NFV, SQV, LPV107M46L, I54V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I64M, C67E, H69K, A71V, I72V, T74S, V82I, L89I, I93LG
Non-B Workgroup (2005)PL3510257431AY900721SQV, NFV, IDV181I54V, L90MF53LI13V, K14KR, K20IV, L33LV, E35D, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T74S, V82I, L89IG
 PL3548458235AY900970NFV M46ML T12A, I13V, K14R, K20T, E35D, M36I, R41K, I62V, L63P, H69K, A71T, T74S, V82I, L89X, I93MG
 PL1087759219AY900976IDV, SQV I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL3606959512AY900981NFV I54V, L90M I13V, K20I, E35N, M36I, N37ND, R41K, H69K, T74S, V82I, L89IG
 PL848759877AY900987SQV L90MF53LL10LI, I13V, K14R, K20I, E35D, M36I, R41K, M46X, I62IV, L63LP, H69K, A71X, T74S, V82I, L89XG
 PL3694361481AY900991NFV73I54IV, L90M I13V, K14R, I15V, K20IV, E35DN, M36I, R41K, H69K, A71T, T74S, V82I, L89IG
 PL86262513AY901003IDV, ATV I54V, V82T, L90M I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71V, T74S, L89IG
 PL2430163125AY901013NFV, RTV, IDV173I54V, I84V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I62IV, L63P, H69K, A71V, T74S, L89IG
 PL1945463189AY901014Unknown, LPV>22M46L, G48GV, I54V, L90ML89VT4TS, L10LV, I13V, K14R, K20I, M36I, N37D, R41EK, I62V, H69K, A71V, T74S, V82XG
 PL3844864783AY901029NFV L90M I13V, K14R, K20I, E35EG, M36I, R41K, D60E, L63P, H69K, T74S, V82I, L89M, I93LG
 PL3832564508AY901035IDV87I54V, V82A L10I, I13V, K14KR, L19LS, K20I, E35D, M36I, N37D, R41K, H69K, A71IV, T74S, L89IG
 PL3690261392AY901077PINAL90M T12TP, I13V, K14R, I15V, K20T, E35D, M36I, R41K, H69K, K70R, A71T, T74S, V82I, L89IG
 PL3414765713AY901095NFV  L23II13V, K14R, K20I, E35G, M36I, R41K, H69K, T74S, V82I, L89I, Q92KG
 PL1087759219 IDV, SQV194I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL14163105581 IDV330I54V I13V, K20I, E35D, M36I, R41K, H69K, T74S, V82I, L89MG
 PL1481477297 NFV221M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, L89I, I93MG
  78800 NFV228M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, R87E, L89I, I93MG
 PL2632060887 NFV171N88S I13V, K14R, K20I, E35N, M36I, R41K, I62V, I64V, H69K, T74S, V82I, L89MG
 PL3613797247 SQV, RTV338L90LIM I13V, K20I, E35D, M36I, N37ND, R41K, H69K, T74S, V82I, L89IMG
 PL3965167522 NFV151I54V, L90M I13V, K14R, K20I, E35N, M36I, R41K, K45KR, I62IV, H69K, A71AV, T74S, V82VI, L89IG
 PL405467728 SQV, NFV, IDV255M46ML, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, D60DE, I62IV, H69K, T74S, V82I, L89IG
  105535 SQV, NFV, IDV267I54V, L90M I13V, K14KR, I15V, K20T, E35D, M36I, R41K, I62V, H69K, T74S, V82I, L89IG
 PL4236173571 RTV, IDV160M46L, G48V, I54V, V82SK43TL10I, I13A, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, T74S, L89IG
 PL4315675500 SQV, NFV281L90M I13V, K14R, I15IV, K20T, E35DN, M36I, R41K, I62IV, H69K, A71T, T74S, V82I, L89IG
 PL4356276535 SQV, IDV86I54V, V82S I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, T74S, L89IG
 PL4404477623 RTV, IDV, NFV104I54V, V82VA L10LI, I13V, K14R, K20I, E35D, M36I, R41K, L63LP, H69K, A71AV, T74S, L89IG
 PL4492479756 Unknown, LPV>82I54V, L90MF53LI13V, I15IV, K20I, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, V82I, L89I, Q92QRG
 PL45291105157 NFV64L90ML23II13V, K20I, E35G, M36I, R41K, H69K, T74S, V82I, L89MG
 PL865105515 SQV486I54V, L90MF53LL10I, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, L63A, H69K, A71V, T74S, V82I, L89IG
 PL1197773201 NFV36L90M I13V, K14R, I15IV, K20T, E35D, M36I, R41K, I62V, H69K, A71T, T74S, V82I, L89IG
Baxter (2006)48-12511251-30602DQ877776PINAM46I, I54V, V82T, I84V, L90ML89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, K55N, I62V, L63P, C67F, H69K, A71V, T74SG
 48-12731273-30904DQ877793PINAM46I, I47V, I54V, V82T, I84VK43T, F53L, L89VL10I, I13A, K14R, K20V, A22V, M36I, N37D, R41K, L63P, I66V, H69K, A71V, T74S, T91TCSG
 48-22122212-30624DQ877865PINAI54V, V82VFI, L90ML23LI, F53FL, L89MVL10LI, I13AV, K14R, K20I, E35G, M36I, R41K, D60E, L63P, H69KR, A71V, T74S, I93LG
 48-31863186-30506DQ878094PINAM46L, I54V, V82A, I84VV11I, L24I, L89IVL10I, I13A, K14R, K20I, A22V, E35D, M36I, R41K, I62V, L63P, C67Y, H69K, A71V, T74S, Q92KG
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TG
Knops (2010)Pat02Pat02GU991863NFV L90M I13V, K20V, E35D, M36I, N37D, G40GE, R41K, H69K, T74S, V82I, L89IG
 Pat06Pat06GU991867NFV L90ML89VI13V, I15V, K20T, E35D, M36I, N37DE, R41K, R57K, I62V, H69K, A71AT, T74S, V82IG
 Pat08Pat08GU991869NFV, IDV, LPV M46I, I54A, V82M, L90MK43TT4A, L10I, I13V, I15V, L19P, K20I, E35S, M36I, N37E, R41K, V56A, R57K, L63P, H69K, A71V, T74S, V77I, L89I, Q92KG
 Pat11Pat11GU991872IDV D30N, I54VL33I, N88D, L89VI13V, L19P, K20I, E35N, M36I, N37D, R41K, K43R, K45Q, H69K, T74S, V82IG
 Pat14Pat14GU991875SQV, LPV M46L, G48V, I54V, V82S, L90MK43TL10I, T12K, I13V, I15V, K20I, E35N, M36I, N37D, R41K, Q61HN, L63C, C67W, H69K, T74S, L89IG
 Pat17Pat17GU991878SQV, LPV M46I, I54V, V82A, L90ML33I, L89VL10V, I13A, K20V, A22V, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, H69K, K70R, A71T, T74SG