<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation I54V
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 81
Isolates 91
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patHEN01_HEN734AJ577913NFV, LPV62I54V, L90M I13V, K20I, E35G, M36I, R41K, H69K, K70R, V82I, L89MG
  02_HEN716AJ577914NFV, LPV85I54V, L90MQ58EI13V, K20I, E35G, M36I, R41K, H69K, K70R, V82I, L89IG
 MB_patGRA00_GRA703AJ577905NFV, SQV, LPV107M46L, I54V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I64M, C67E, H69K, A71V, I72V, T74S, V82I, L89I, I93LG
 MB_patRAM02_RAM705AJ577980Unknown, RTV, IDV>120M46L, G48V, I54V, V82T L10V, I13V, K20I, M36I, N37D, R41K, I66F, H69K, K70R, L89MG
 MB_patPAL01_PAL708AJ577968SQV, RTV, NFV251D30N, M46L, I54V, L90ML33I, N88D, L89VI13V, K20I, M36I, N37K, L63P, C67S, H69K, A71VG
Non-B Workgroup (2005)PL875856741AY900713SQV, RTV, IDV229G48M, I54V, V82T, L90MF53LI13V, K14R, K20I, E35D, M36I, R41K, Q61H, H69K, A71V, L89IG
 PL529657203AY900717SQV, NFV, IDV I54V, V82M, L90MF53LI13A, K14R, I15V, K20I, E35D, M36I, R41K, I62IV, C67CW, H69K, T74A, L89IG
 PL3510257431AY900721SQV, NFV, IDV181I54V, L90MF53LI13V, K14KR, K20IV, L33LV, E35D, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T74S, V82I, L89IG
 PL3379057583AY900722NFV I54V, L90ML33LII13V, K14R, K20IT, E35D, M36I, N37D, R41K, H69K, V82I, L89IG
 PL87158009AY900725IDV, RTV108I54V, V82AL89VI13V, K14R, I15IV, K20I, E35D, M36I, R41K, M46X, L63LP, H69K, A71V, I93IMG
 PL1087759219AY900976IDV, SQV I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL3516757581AY900979IDV, RTV47I54VL24II13V, K14R, K20I, E35D, M36I, N37K, R41K, L63P, H69K, V82I, L89MG
 PL3606959512AY900981NFV I54V, L90M I13V, K20I, E35N, M36I, N37ND, R41K, H69K, T74S, V82I, L89IG
 PL3707461791AY900989IDV M46L, I54V I13V, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, K70R, V82I, L89MG
 PL887561905AY900995IDV M46I, I54V, V82T, I84VQ58EL10I, I13V, K20I, E35D, M36I, R41K, L63P, I66F, H69K, A71AV, T74K, L89MG
 PL3713261949AY900996IDV M46MI, G48GV, I54V, V82T, I84IV, L90LML89MVI13V, K14R, K20I, M36I, R41K, I66IF, H69K, A71VG
 PL86262513AY901003IDV, ATV I54V, V82T, L90M I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71V, T74S, L89IG
 PL2647363176AY901007SQV, NFV, IDV, RTV, LPV I54V, V82F, L90ML89VL10I, I13V, K14R, K20I, E35N, M36I, N37ND, R41K, L63P, H69K, A71V, Q92QKG
  89488 SQV, NFV, IDV, RTV, LPV, UnknownNAM46I, I50V, I54V, V82F, L90ML89VL10I, I13A, K14R, K20IT, A22AV, E35N, M36I, N37D, R41K, L63P, I66V, C67CR, H69K, K70KT, A71V, I85IV, Q92KG
 PL3729062297AY901009NFV87I54V, L90M I13V, K20T, E35D, M36I, R41K, H69K, V82I, L89IG
 PL3126062984AY901012IDV208M46I, I54V, V82SL89VL10LI, I13V, I15V, L19LP, K20I, E35D, M36I, N37ND, R41K, I62IV, L63LP, H69K, K70KR, A71VG
 PL2430163125AY901013NFV, RTV, IDV173I54V, I84V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I62IV, L63P, H69K, A71V, T74S, L89IG
 PL1945463189AY901014Unknown, LPV>22M46L, G48GV, I54V, L90ML89VT4TS, L10LV, I13V, K14R, K20I, M36I, N37D, R41EK, I62V, H69K, A71V, T74S, V82XG
 PL3820164222AY901019SQV, IDV M46MI, I54V, V82M, L90M I13AV, K14R, I15IV, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, K70R, L89IG
 PL3031563371AY901022IDV M46I, I54V, V82T, I84VL89VL10I, I13A, K14R, K20I, E35D, M36I, N37ND, R41K, L63LP, I66F, H69K, A71V, I85IMG
 PL3814564117AY901026SQV, IDV238M46I, I54V, V82T, I84V L10I, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63P, I66F, H69K, K70R, L89MG
 PL3832564508AY901035IDV87I54V, V82A L10I, I13V, K14KR, L19LS, K20I, E35D, M36I, N37D, R41K, H69K, A71IV, T74S, L89IG
 PL888465233AY901039SQV, IDV, LPV M46I, I54V, L76V, L90MF53L, L89VL10I, I13A, K14R, I15IV, K20I, E35D, M36I, R41K, Q61QH, L63P, H69K, A71IT, V82X, T91TSG
 PL1003066215AY901040SQV, IDV I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
 PL3595467123AY901045SQV, IDV, NFV I54V, L90M I13V, K14R, K20I, E35N, M36I, R41K, K45R, H69K, A71AV, V82I, L89IG
 PL1584967492 IDV I54VL89VI13V, K14KR, K20I, E35D, M36I, R41K, L63P, H69K, A71TG
 PL846867575 RTV74I54V, L90MQ58EI13V, K14R, K20I, E35D, M36I, R41K, L63P, H69K, V82I, L89MG
 PL3980567858AY901056NFV117I54V, L90M I13V, K14R, K20IT, E35DN, M36I, R41K, H69K, V82I, L89IG
 PL1168468720AY901063IDV I54V, V82T, I84V, L90LML33LI, L89VL10I, I13A, K14KR, K20I, E35D, M36I, R41K, I66F, H69K, A71VG
 PL985667800AY901068NFV, RTV M46I, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, I62V, H69K, T74A, V82I, L89I, I93LG
 PL4041269106AY901069IDV117I54V, V82M, L90M I13V, K20I, E35D, M36I, R41K, L63LP, H69K, L89IG
 TK2013TK2013 IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
  TK2013a IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
  TK2013b IDV, SQV, RTV, NFV, LPV, APV225M46I, I47V, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89IM, Q92KG
 PL1003066215 SQV, IDV275I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
 PL1014683346 RTV, IDV151M46I, I54V, V82T I13V, K14R, K20I, E35D, M36I, N37ND, R41K, I62V, I66F, H69K, L89MG
 PL1087759219 IDV, SQV194I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63LP, H69K, A71V, T74S, L89I, T91TN, T96TNG
 PL14163105581 IDV330I54V I13V, K20I, E35D, M36I, R41K, H69K, T74S, V82I, L89MG
 PL28120100793 LPV39M46MI, I54V, L76VL24LI, Q58EL10I, I13V, K20I, E35D, M36I, R41K, L63P, H69K, V82I, L89MG
 PL2824476856 IDV91I54V, L90ML33LII13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89IG
 PL2909097083 IDV, NFV, SQV, RTV179M46L, G48V, I54V, V82T L10I, I13V, K14R, K20I, E35DN, M36V, R41Q, H69K, K70E, A71V, L89I, I93LG
 PL30594104269 NFV288M46L, I54VL89VT12TI, I13A, K14R, L19P, K20I, E35D, M36I, N37D, R41K, H69K, V82IG
 PL3237374841 IDV, NFV, RTV148I54V, L90ML89VI13V, K14R, I15V, K20T, E35D, M36I, R41K, Q61E, H69K, K70R, V82IG
 PL3263599822 IDV, SQV, RTV216I54V, L90MF53LI13V, K14R, L19I, K20I, E35D, M36I, R41K, L63LP, H69K, A71V, V82I, L89IG
 PL3373076228 Unknown, RTV, IDV>80I54V, V82F L10I, I13V, K14R, K20I, E35D, M36I, R41K, K45Q, H69K, L89MG
 PL3432698448 IDV, NFV180I54V, V82ML24I, Q58E, L89MVL10I, I13V, K14R, K20I, E35D, M36I, R41K, Q61N, L63T, H69KG
 PL3704676044 IDV130I54V I13V, K14R, K20I, E35D, M36I, R41K, I66IF, H69K, L89MG
 PL3965167522 NFV151I54V, L90M I13V, K14R, K20I, E35N, M36I, R41K, K45KR, I62IV, H69K, A71AV, T74S, V82VI, L89IG
 PL40388105421 IDV190M46MI, I54V, V82T, I84VL89MVL10I, I13V, K14R, I15V, K20I, E35D, M36I, R41K, Q61QH, I62IV, L63LAPV, I66FL, H69K, A71AV, T74TSG
 PL405467728 SQV, NFV, IDV255M46ML, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, D60DE, I62IV, H69K, T74S, V82I, L89IG
  105535 SQV, NFV, IDV267I54V, L90M I13V, K14KR, I15V, K20T, E35D, M36I, R41K, I62V, H69K, T74S, V82I, L89IG
 PL4208372851 NFV, RTV, IDV214M46I, I54V, V82F, L90M L10I, I13V, K14R, I15IV, K20I, E35D, M36V, N37ND, R41K, R57RK, D60DE, L63LP, H69K, A71AV, L89IG
 PL4236173571 RTV, IDV160M46L, G48V, I54V, V82SK43TL10I, I13A, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, T74S, L89IG
 PL4307775315 NFV224M46L, I54V, L90M I13V, K14R, L19I, K20I, E35N, M36I, R41K, K55KR, R57RK, H69K, V82I, L89MG
 PL4356276535 SQV, IDV86I54V, V82S I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, T74S, L89IG
 PL4404477623 RTV, IDV, NFV104I54V, V82VA L10LI, I13V, K14R, K20I, E35D, M36I, R41K, L63LP, H69K, A71AV, T74S, L89IG
 PL4423878139 IDV106M46I, I54V, V82T L10LI, I13V, K20I, E35D, M36I, R41K, I66F, H69K, L89MG
 PL4432678321 IDV263M46I, I54V, L90M I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89M, I93MG
 PL4492479756 Unknown, LPV>82I54V, L90MF53LI13V, I15IV, K20I, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, V82I, L89I, Q92QRG
 PL4586782009 IDV218I54V I13V, K14R, K20I, E35D, M36I, R41K, I64IL, H69K, V82I, L89MG
  100992 IDV277I54V I13V, K14R, K20I, E35D, M36I, R41K, I64IL, H69K, V82I, L89MG
 PL5048894311 RTV, IDV84I54V, V82T, I84V, L90M I13V, K14R, I15V, K20I, E35D, M36I, R41K, C67F, H69K, A71V, L89IG
 PL5246199339 IDV178I54V, V82T, L90M L10LI, I13V, K14R, I15V, K20I, E35D, M36I, R41K, I62IV, L63LP, C67W, H69K, A71V, L89IG
 PL54919106008 IDV, LPV169M46I, I54V, V82SL24IL10LIV, I13V, K14R, K20I, E35DN, M36I, R41K, L63P, H69K, L89MG
 PL86570861 SQV420I54V, L90MRF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60DE, L63AP, H69K, A71V, V82I, L89IMG
  105515 SQV486I54V, L90MF53LL10I, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, L63A, H69K, A71V, T74S, V82I, L89IG
Weber (2005)M64940M64940AY677452IDV, NFV, LPV293G48A, I54V, V82S, L90ML89VL10I, I13A, K14R, K20I, M36I, N37D, R41K, L63P, H69K, A71VG
  M64940AY714453IDV, NFV195G48A, I54V, V82S, L90ML89VL10I, I13A, K14R, K20I, M36I, N37D, R41K, L63P, H69K, K70KR, A71VG
Baxter (2006)48-12171217-30701DQ877755PINAI54V, V82A, L90MV11I, F53LL10V, T12K, I13V, K14R, G16E, K20I, L33L_L, E35D, M36I, R41K, I62V, H69K, A71V, L89IG
 48-12511251-30602DQ877776PINAM46I, I54V, V82T, I84V, L90ML89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, K55N, I62V, L63P, C67F, H69K, A71V, T74SG
 48-12731273-30904DQ877793PINAM46I, I47V, I54V, V82T, I84VK43T, F53L, L89VL10I, I13A, K14R, K20V, A22V, M36I, N37D, R41K, L63P, I66V, H69K, A71V, T74S, T91TCSG
 48-22122212-30624DQ877865PINAI54V, V82VFI, L90ML23LI, F53FL, L89MVL10LI, I13AV, K14R, K20I, E35G, M36I, R41K, D60E, L63P, H69KR, A71V, T74S, I93LG
 48-22252225-30423DQ877867PINAM46I, I47V, I54V, V82AF53LI13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TSG
 48-31863186-30506DQ878094PINAM46L, I54V, V82A, I84VV11I, L24I, L89IVL10I, I13A, K14R, K20I, A22V, E35D, M36I, R41K, I62V, L63P, C67Y, H69K, A71V, T74S, Q92KG
 48-33183318-30924DQ878218PINAG48V, I54V, V82M, L90MK43T, T74PL10V, T12TK, I13V, K20I, E35D, M36IV, N37D, R41K, Q61QH, I62V, C67E, H69K, L89MG
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TG
 48-43944394-30912DQ878533PINAM46I, I54V, L76V, V82F L10I, I13V, G16GA, K20I, E35D, M36I, L63P, H69K, T74TS, L89MG
 48-80048004-30514DQ879049PINAM46L, I54V, V82A I13V, K20I, A22AV, E35D, M36I, R41K, R57K, L63P, I66F, A71V, T91AG
 48-80768076-30925DQ879086PINAM46I, I54V, L76V, I84VQ58EL10I, I13V, K14R, I15V, K20I, E35N, M36I, N37D, R57RK, D60Q, L63P, H69K, V82I, L89MG
von Wyl (2007)53700437EF449874PINAI54V, L90LM I13V, K14R, K20I, L33V, E35Q, M36I, R41K, R57K, D60DE, C67E, H69K, V82I, L89IG
Knops (2010)Pat07Pat07GU991868LPV M46I, I54V, L76V, V82MQ58EL10V, I13A, K20IM, A22AV, E35D, M36I, R41RK, I62IV, L63P, H69K, L89I, T91SG
 Pat11Pat11GU991872IDV D30N, I54VL33I, N88D, L89VI13V, L19P, K20I, E35N, M36I, N37D, R41K, K43R, K45Q, H69K, T74S, V82IG
 Pat14Pat14GU991875SQV, LPV M46L, G48V, I54V, V82S, L90MK43TL10I, T12K, I13V, I15V, K20I, E35N, M36I, N37D, R41K, Q61HN, L63C, C67W, H69K, T74S, L89IG
 Pat17Pat17GU991878SQV, LPV M46I, I54V, V82A, L90ML33I, L89VL10V, I13A, K20V, A22V, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, H69K, K70R, A71T, T74SG
 Pat19Pat19GU991880LPV M46I, I50V, I54V, V82MV11VI, F53LL10V, T12S, I13V, I15IV, L19P, K20I, E35DN, M36I, R41K, K45V, Q61QH, I64V, C67CY, G68D, H69K, A71V, L89IG
Barber (2012)6806168061JQ361672LPV I54V, L90LM I13V, K14R, K20I, E35Q, M36I, N37NDEK, R41K, I62IV, L63P, C67E, H69K, A71AV, V82I, L89M, I93IMG

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