<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation F53L
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 22
Isolates 24
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cuevas (2002)CU75CU75AF425456SQV L90MF53L, L89VL10V, I13V, K20I, M36I, R41K, Q61E, H69K, K70R, A71V, T74SG
Non-B Workgroup (2005)PL875856741AY900713SQV, RTV, IDV229G48M, I54V, V82T, L90MF53LI13V, K14R, K20I, E35D, M36I, R41K, Q61H, H69K, A71V, L89IG
 PL529657203AY900717SQV, NFV, IDV I54V, V82M, L90MF53LI13A, K14R, I15V, K20I, E35D, M36I, R41K, I62IV, C67CW, H69K, T74A, L89IG
 PL3510257431AY900721SQV, NFV, IDV181I54V, L90MF53LI13V, K14KR, K20IV, L33LV, E35D, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T74S, V82I, L89IG
 PL848759877AY900987SQV L90MF53LL10LI, I13V, K14R, K20I, E35D, M36I, R41K, M46X, I62IV, L63LP, H69K, A71X, T74S, V82I, L89XG
 PL881364115AY901027SQV, NFV204L90MF53L, L89VI13V, K14KR, K20I, E35D, M36I, R41K, L63P, H69K, A71V, V82IG
 PL2745264378AY901034SQV L90MF53LI13V, K14R, K20I, E35D, M36I, R41K, H69K, A71V, V82I, L89IG
 PL888465233AY901039SQV, IDV, LPV M46I, I54V, L76V, L90MF53L, L89VL10I, I13A, K14R, I15IV, K20I, E35D, M36I, R41K, Q61QH, L63P, H69K, A71IT, V82X, T91TSG
 PL1003066215AY901040SQV, IDV I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
  66215 SQV, IDV275I54V, V82A, L90MF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60E, L63P, C67CF, H69K, A71V, L89IG
 PL3263599822 IDV, SQV, RTV216I54V, L90MF53LI13V, K14R, L19I, K20I, E35D, M36I, R41K, L63LP, H69K, A71V, V82I, L89IG
 PL4492479756 Unknown, LPV>82I54V, L90MF53LI13V, I15IV, K20I, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, V82I, L89I, Q92QRG
 PL86570861 SQV420I54V, L90MRF53LL10I, I13V, K14R, K20I, E35D, M36I, R41K, D60DE, L63AP, H69K, A71V, V82I, L89IMG
  105515 SQV486I54V, L90MF53LL10I, I13V, K14KR, K20I, E35D, M36I, N37D, R41K, L63A, H69K, A71V, T74S, V82I, L89IG
Baxter (2006)48-12171217-30701DQ877755PINAI54V, V82A, L90MV11I, F53LL10V, T12K, I13V, K14R, G16E, K20I, L33L_L, E35D, M36I, R41K, I62V, H69K, A71V, L89IG
 48-12731273-30904DQ877793PINAM46I, I47V, I54V, V82T, I84VK43T, F53L, L89VL10I, I13A, K14R, K20V, A22V, M36I, N37D, R41K, L63P, I66V, H69K, A71V, T74S, T91TCS, F99LG
 48-22252225-30423DQ877867PINAM46I, I47V, I54V, V82AF53LI13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TSG
 48-80118011-30506DQ879056PINAM46I, I50VL33F, F53LI13V, K14R, K20T, E35R, M36I, N37D, R41K, L63LP, C67E, H69K, T74A, V82I, L89MG
Knops (2010)Pat19Pat19GU991880LPV M46I, I50V, I54V, V82MV11VI, F53LL10V, T12S, I13V, I15IV, L19P, K20I, E35DN, M36I, R41K, K45V, Q61QH, I64V, C67CY, G68D, H69K, A71V, L89IG
Kouri (2012)CU2040-09CU2040-09JQ585334PINAM46I, I47V, I50V, I54VF53LL10I, I13V, G16E, K20I, E35N, M36MV, N37S, R41K, I66F, H69K, K70R, T74S, V82I, L89MG
Rawizza (2013)LM4439LM4439KF241483LPV M46I, I47V, I54V, V82SV11I, L24I, F53LL10I, I13V, K14R, I15V, G16A, K20I, E35Q, M36I, N37D, R41K, K55R, R57K, L63P, C67E, H69K, A71V, L89I, T91SG
 OU8939OU8939KF241475LPV M46I, I50V, I54V, L76V, L90LML23I, L33F, F53LI13V, K20IL, E34D, E35Q, M36I, N37E, R41K, R57K, Q61QH, L63P, C67E, H69R, T74TS, V82I, L89MG
 PJ6749PJ6749KF241460LPV M46L, G48Q, I54V, L76V, I84VF53LL10V, I13A, K14R, I15V, K20I, E35H, M36I, R41K, K55R, R57K, Q61HN, I64V, C67E, H69K, T74S, L89I, T91AG
Diaz (2015)RenG15783RenG15783KT746811PINAI54V, L90ML23I, L33I, F53LI13V, K20I, E35S, M36I, K45N, R57K, I62V, L63P, H69K, V82I, L89IM, I93L, C95FG