<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation M46L
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 15
Isolates 16
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patGRA00_GRA703AJ577905NFV, SQV, LPV107M46L, I54V, L90M I13V, K14R, K20I, E35D, M36I, R41K, I64M, C67E, H69K, A71V, I72V, T74S, V82I, L89I, I93LG
 MB_patRAM02_RAM705AJ577980Unknown, RTV, IDV>120M46L, G48V, I54V, V82T L10V, I13V, K20I, M36I, N37D, R41K, I66F, H69K, K70R, L89MG
 MB_patPAL99_PAL710AJ577967SQV, RTV, NFV130D30N, M46L, L90ML33I, N88D, L89VI13V, K20I, M36I, L63P, C67S, H69K, A71VG
  01_PAL708AJ577968SQV, RTV, NFV251D30N, M46L, I54V, L90ML33I, N88D, L89VI13V, K20I, M36I, N37K, L63P, C67S, H69K, A71VG
Non-B Workgroup (2005)PL3707461791AY900989IDV M46L, I54V I13V, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, K70R, V82I, L89MG
 PL1945463189AY901014Unknown, LPV>22M46L, G48GV, I54V, L90ML89VT4TS, L10LV, I13V, K14R, K20I, M36I, N37D, R41EK, I62V, H69K, A71V, T74S, V82XG
 PL2909097083 IDV, NFV, SQV, RTV179M46L, G48V, I54V, V82T L10I, I13V, K14R, K20I, E35DN, M36V, R41Q, H69K, K70E, A71V, L89I, I93LG
 PL30594104269 NFV288M46L, I54VL89VT12TI, I13A, K14R, L19P, K20I, E35D, M36I, N37D, R41K, H69K, V82IG
 PL4236173571 RTV, IDV160M46L, G48V, I54V, V82SK43TL10I, I13A, K14R, K20I, E35D, M36I, R41K, I62V, I66F, H69K, T74S, L89IG
 PL4307775315 NFV224M46L, I54V, L90M I13V, K14R, L19I, K20I, E35N, M36I, R41K, K55KR, R57RK, H69K, V82I, L89MG
Baxter (2006)48-31863186-30506DQ878094PINAM46L, I54V, V82A, I84VV11I, L24I, L89IVL10I, I13A, K14R, K20I, A22V, E35D, M36I, R41K, I62V, L63P, C67Y, H69K, A71V, T74S, Q92KG
 48-80048004-30514DQ879049PINAM46L, I54V, V82A I13V, K20I, A22AV, E35D, M36I, R41K, R57K, L63P, I66F, A71V, T91AG
Knops (2010)Pat14Pat14GU991875SQV, LPV M46L, G48V, I54V, V82S, L90MK43TL10I, T12K, I13V, I15V, K20I, E35N, M36I, N37D, R41K, Q61HN, L63C, C67W, H69K, T74S, L89IG
Kouri (2012)CU1566-10CU1566-10JQ585436PINAV32I, M46L, I47A, L90M I13AV, K14R, I15V, K20I, E35D, M36I, N37ND, R41K, L63P, H69K, V82I, L89IG
 CU599-10CU599-10JQ585404PINAM46L, I50V L10V, I13V, G16E, K20I, E35D, M36I, R41K, H69K, K70R, T74S, V82I, L89MG
Rawizza (2013)PJ6749PJ6749KF241460LPV M46L, G48Q, I54V, L76V, I84VF53LL10V, I13A, K14R, I15V, K20I, E35H, M36I, R41K, K55R, R57K, Q61HN, I64V, C67E, H69K, T74S, L89I, T91AG