<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype G
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 48
Isolates 51
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Vergne (2003)VL01SN63HPD01SN63AJ583750IDV M46I, V82TL89VL10I, I13V, K14R, K20I, E35D, M36I, R41K, L63P, C67E, H69KG
Montes (2004)MB_patVIG02_VIG701AJ578178SQV, RTV, IDV252M46I, I54A, V82T L10I, I13V, K14R, K20I, E35N, M36I, N37D, R41K, Q61H, L63P, C67E, H69K, I72V, T74S, L89MG
Non-B Workgroup (2005)PL1708257141AY900715IDV30M46I, V82S I13V, K20I, E35D, M36I, R41K, K45R, L63P, I66F, H69K, K70R, L89MG
 PL887561905AY900995IDV M46I, I54V, V82T, I84VQ58EL10I, I13V, K20I, E35D, M36I, R41K, L63P, I66F, H69K, A71AV, T74K, L89MG
 PL2647389488 SQV, NFV, IDV, RTV, LPV, UnknownNAM46I, I50V, I54V, V82F, L90ML89VL10I, I13A, K14R, K20IT, A22AV, E35N, M36I, N37D, R41K, L63P, I66V, C67CR, H69K, K70KT, A71V, I85IV, Q92KG
 PL3126062984AY901012IDV208M46I, I54V, V82SL89VL10LI, I13V, I15V, L19LP, K20I, E35D, M36I, N37ND, R41K, I62IV, L63LP, H69K, K70KR, A71VG
 PL3031563371AY901022IDV M46I, I54V, V82T, I84VL89VL10I, I13A, K14R, K20I, E35D, M36I, N37ND, R41K, L63LP, I66F, H69K, A71V, I85IMG
 PL3814564117AY901026SQV, IDV238M46I, I54V, V82T, I84V L10I, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63P, I66F, H69K, K70R, L89MG
 PL888465233AY901039SQV, IDV, LPV M46I, I54V, L76V, L90MF53L, L89VL10I, I13A, K14R, I15IV, K20I, E35D, M36I, R41K, Q61QH, L63P, H69K, A71IT, V82X, T91TSG
 PL3938066862AY901046IDV100M46I, V82TL89MVI13V, K14R, K20I, E35D, M36I, R41K, I64IV, H69KG
 PL3311666967AY901052NFV M46I, L90M I13V, K20IV, E35DN, M36I, R41K, I64V, H69K, K70KR, A71AV, V82I, L89IM, I93MG
 PL985667800AY901068NFV, RTV M46I, I54V, L90M I13V, K14R, I15V, K20T, E35DN, M36I, R41K, I62V, H69K, T74A, V82I, L89I, I93LG
 TK2013TK2013 IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
  TK2013a IDV, SQV, RTV, NFV196M46I, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92KG
  TK2013b IDV, SQV, RTV, NFV, LPV, APV225M46I, I47V, I54V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89IM, Q92KG
 PL1014683346 RTV, IDV151M46I, I54V, V82T I13V, K14R, K20I, E35D, M36I, N37ND, R41K, I62V, I66F, H69K, L89MG
 PL1481477297 NFV221M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, L89I, I93MG
  78800 NFV228M46I, L90M I13V, K14R, K20I, E35D, M36V, R41K, Q61H, I62V, L63P, C67E, H69K, A71I, T74S, V82I, R87E, L89I, I93MG
 PL4208372851 NFV, RTV, IDV214M46I, I54V, V82F, L90M L10I, I13V, K14R, I15IV, K20I, E35D, M36V, N37ND, R41K, R57RK, D60DE, L63LP, H69K, A71AV, L89IG
 PL4268876257 RTV, IDV29M46I, V82T I13V, K20I, E35D, M36I, R41K, H69K, L89MG
 PL4423878139 IDV106M46I, I54V, V82T L10LI, I13V, K20I, E35D, M36I, R41K, I66F, H69K, L89MG
 PL4432678321 IDV263M46I, I54V, L90M I13V, K14KR, K20I, E35D, M36I, R41K, H69K, V82I, L89M, I93MG
 PL4469979216 IDV256M46I, V82T, I84IV, L90ML89VI13AV, K14KR, I15V, K20I, E35D, M36I, N37ND, R41RK, L63P, H69K, A71ATG
 PL45677100951 IDV43M46I, L90LM I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, L89IG
 PL53397101698 IDV114M46I, L90M T12TA, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TG
 PL54919106008 IDV, LPV169M46I, I54V, V82SL24IL10LIV, I13V, K14R, K20I, E35DN, M36I, R41K, L63P, H69K, L89MG
Baxter (2006)48-12511251-30602DQ877776PINAM46I, I54V, V82T, I84V, L90ML89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, K55N, I62V, L63P, C67F, H69K, A71V, T74SG
 48-12731273-30904DQ877793PINAM46I, I47V, I54V, V82T, I84VK43T, F53L, L89VL10I, I13A, K14R, K20V, A22V, M36I, N37D, R41K, L63P, I66V, H69K, A71V, T74S, T91TCSG
 48-22252225-30423DQ877867PINAM46I, I47V, I54V, V82AF53LI13V, K14R, K20I, E35D, M36I, N37D, R41K, L63P, H69K, K70R, A71IV, L89I, T91TSG
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TG
 48-43944394-30912DQ878533PINAM46I, I54V, L76V, V82F L10I, I13V, G16GA, K20I, E35D, M36I, L63P, H69K, T74TS, L89MG
 48-80118011-30506DQ879056PINAM46I, I50VL33F, F53LI13V, K14R, K20T, E35R, M36I, N37D, R41K, L63LP, C67E, H69K, T74A, V82I, L89MG
 48-80768076-30925DQ879086PINAM46I, I54V, L76V, I84VQ58EL10I, I13V, K14R, I15V, K20I, E35N, M36I, N37D, R57RK, D60Q, L63P, H69K, V82I, L89MG
Knops (2010)Pat07Pat07GU991868LPV M46I, I54V, L76V, V82MQ58EL10V, I13A, K20IM, A22AV, E35D, M36I, R41RK, I62IV, L63P, H69K, L89I, T91SG
 Pat08Pat08GU991869NFV, IDV, LPV M46I, I54A, V82M, L90MK43TT4A, L10I, I13V, I15V, L19P, K20I, E35S, M36I, N37E, R41K, V56A, R57K, L63P, H69K, A71V, T74S, V77I, L89I, Q92KG
 Pat17Pat17GU991878SQV, LPV M46I, I54V, V82A, L90ML33I, L89VL10V, I13A, K20V, A22V, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, H69K, K70R, A71T, T74SG
 Pat19Pat19GU991880LPV M46I, I50V, I54V, V82MV11VI, F53LL10V, T12S, I13V, I15IV, L19P, K20I, E35DN, M36I, R41K, K45V, Q61QH, I64V, C67CY, G68D, H69K, A71V, L89IG
Kouri (2012)CU1023-09CU1023-09JQ585273PINAM46I, I54V, V82T, I84VL89VL10I, I13A, K14R, K20IV, M36I, N37D, R41K, K55R, R57RG, I66F, H69K, G73E, T74S, T80VG
 CU2143-09CU2143-09JQ585346PINAM46I, V82T, I84V, L90ML33I, L89VL10I, I13A, K20I, M36I, R41K, L63LP, C67E, H69K, A71VG
 CU2040-09CU2040-09JQ585334PINAM46I, I47V, I50V, I54VF53LL10I, I13V, G16E, K20I, E35N, M36MV, N37S, R41K, I66F, H69K, K70R, T74S, V82I, L89MG
 CU330-10CU330-10JQ585385PINAM46I, I47V, G48M, I54V, V82T, I84VL33I, L89VL10I, I13A, K20V, A22V, E35HN, M36I, R41K, K43I, I62IV, I66F, G68D, H69K, A71V, T91SG
 CU268-11CU268-11JQ585486PINAM46I, V82T L10I, I13V, K20IM, M36I, R41K, I66F, H69K, K70R, L76L*, L89MG
 CU963-10CU963-10JQ585420PINAM46I, I47V, I54IV I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74TS, V82VI, L89MG
 CU1967-10CU1967-10JQ585445PINAM46I, I50VL24I, L33F, T74PI13V, K14R, K20V, E35D, M36I, R41K, H69K, V82I, L89MG
Rawizza (2013)LN6209LN6209KF241496LPV M46I, I54V, V82A I13V, G17E, K20I, M36I, N37N_N, R41K, I62V, E65Q, H69K, L89MG
 LM4439LM4439KF241483LPV M46I, I47V, I54V, V82SV11I, L24I, F53LL10I, I13V, K14R, I15V, G16A, K20I, E35Q, M36I, N37D, R41K, K55R, R57K, L63P, C67E, H69K, A71V, L89I, T91SG
 OU8939OU8939KF241475LPV M46I, I50V, I54V, L76V, L90LML23I, L33F, F53LI13V, K20IL, E34D, E35Q, M36I, N37E, R41K, R57K, Q61QH, L63P, C67E, H69R, T74TS, V82I, L89MG
 LN0609LN0609KF241484LPV M46I, I54V, V82SL24I, K43TL10V, I13V, K14R, G16GA, K20I, E35D, M36I, R41K, R57K, I62V, L63P, C67E, H69R, I72V, T74A, L89MG
 PJ4671PJ4671KF241502LPV M46I, I54V, V82TL24IL10I, I13V, K14R, G17E, K20I, E35Q, M36I, R41K, R57K, I62V, L63P, C67E, H69K, L89MG
 LL3229LL3229KF241463LPV M46I, I50IV, I54IV, V82IST74TPL10M, I13V, K14R, K20I, E35H, M36I, R41K, R57K, Q61QH, L63P, C67E, H69K, A71AV, L89MG
Grossman (2014)10431043 NFV, LPV52M46I, I54V, V82F, L90M I13V, K14R, K20I, E35H, M36I, N37D, R41K, K55R, L63P, C67E, H69K, A71I, L89I, I93MG