<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation I93L
Rx PI-naive
IncludeMixtures No
References 52
Patients 100
Isolates 100
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Op de Coul (2000)CE97R99CE97R99AF204049None   L10V, I15V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63T, E65D, I72T, L89M, I93LF
Vergne (2000)95cm-mp25595CMMP255AJ249236None   T12A, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69Q, I93LF
 LVMP1035LVMP1035AJ286977None   L10I, I15V, K20R, E35D, M36I, R41K, K45R, I62V, H69Q, L89M, I93LF
Carr (2001)ARMA038ARMA038AY037281None   T12E, I15V, E35D, M36I, R41K, K43R, R57K, Q61D, I93LF
Servais (2001)JS97287JS97287AJ012427None   L10I, T12N, I15V, K20M, E35D, M36I, P39Q, R41K, R57K, Q61N, L63I, I72T, L89M, I93LF
Fonjungo (2002)CM223CM223AY051202None   L10V, I15V, L19I, K20R, E35D, M36I, R41K, R57K, V77I, L89M, I93LF
 CM214CM214AY051201None   L10V, I15V, G16E, K20R, M36I, R41K, I62V, L63H, H69Q, K70E, L89M, I93LF
 CM100CM100AY051200None   I13V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, H69Q, I72V, V82I, L89M, I93LF
 CM1CM1AY051199None   L10V, I15V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, H69Q, I72V, V82I, L89M, I93LF
Brindeiro (2003)BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRSP364BRSP364AY213196None   K14R, Q18L, E35D, M36I, R41K, R57K, Q61N, L63C, I72T, V77I, L89M, I93LF
 BRNE132BRNE132AY213326None   I15V, E35D, M36I, R41K, R57K, D60E, Q61D, V77I, L89M, I93LF
Shafer (2003)A384_27762776aEF548517None   K14KR, I15V, G17GE, E35D, M36I, R41K, R57K, Q61N, I72V, V77VI, V82I, L89M, I93LF
Eshleman (2004)BrRJ036BrRJ036AY444302None   I15V, E35D, M36I, R41K, R57K, Q61N, L89M, I93LF
Ndongmo (2006)CM72CBN_CM72DQ394167None   L10V, I13V, I15V, K20R, M36I, N37D, I62V, L63P, I72T, L89M, I93LF
 CM213CBN_CM213DQ394169None   I15V, K20R, E35D, M36I, R41K, H69Q, L89M, I93LF
Petroni (2006)AP_ARRP044AP_ARRP044DQ345497None   L10I, T12K, K14R, I15V, G17E, M36I, R41K, R57K, Q61N, L63C, C67S, K70R, I93LF
Santos (2006)144144PR_RTAY275771None   E35D, N37D, R41K, I62V, L63P, V77I, L89M, I93LF
Dilernia (2007)F043F043EF120104None   E35D, M36I, R41K, R57K, Q61N, L63PS, T74A, I93LF
 F234F234EF120189None   G16E, M36I, R57K, Q61N, I72T, V82I, L89M, I93LF
 F299F299EF120218None   T12Q, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, I72T, I93LF
 N75N75EF120328None   T12S, I15V, L19I, E35D, M36I, R41K, R57K, D60E, Q61D, I62IV, L63LP, H69HY, I72T, I93LF
 F003F003EF120340None   I15V, L19I, E35D, R41K, R57K, Q61N, L63S, I93LF
Eyer-Silva (2007)BRSQ6905BRSQ69EF042667None   K14R, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63C, V77I, V82I, L89M, I93LF
Liu (2007)fj52fj52EF432685None   L10I, G16E, M36I, R41K, K43R, R57K, Q61D, A71T, I72R, I93LF
Paraschiv (2007)21522152_2004JQ082992None   L10I, T12I, I13A, G16E, A22V, E35D, M36I, R41K, R57RK, L63T, L89I, I93LF
 304304_2004JQ082997None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, I72T, L89M, I93LF
 632632_2004JQ083008None   L10V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LF
 894894_2004JQ083012None   T12L, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LF
Rios (2007)CH110MR_CH110EF194012None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, L89M, I93LF
Sucupira (2007)BRR_06_00BRR_06_00DQ902930None   N37D, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
Vicenti (2007)535173191REF376555None   K14R, G17E, K20M, E35D, M36MI, R41K, R57K, Q61N, L63H, V77I, L89M, I93LF
Cuevas (2009)X2592_1X2592_1GU326146None   E35D, M36I, R41K, R57K, Q61N, L63A, L89M, I93LF
 X2657_1X2657_1GU326163None   E35D, M36I, R41K, R57K, Q61N, L63A, L89M, I93LF
Dumans (2009)236PRPA236PRPAFJ405140None   K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L89M, I93LF
Hawkins (2009)Q242ZZQ242FJ931229None   L10I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69Q, L89M, I93LF
Vercauteren (2009)pt2096738462914GQ398928None   T12I, I13V, I15V, G17D, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L89M, I93LF
 pt10976618907335GQ399927None   I15V, E35D, M36I, R41K, R57K, Q61N, I64M, L89M, I93LF
Arruda (2010)105816CE081058JQ230646None   T12N, E35D, M36I, R41K, R57K, D60E, Q61N, V77I, L89M, I93LF
de Felipe (2011)SE73PR_SE73JF338683None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61H, L63T, E65D, I72T, L89M, I93LF
Ferreira (2011)BRMT2526BRMT2526HQ638704None   L10I, Q18L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89M, I93LF
Florea (2011)1368_20081368_2008JQ083027None   T12Q, I15V, L19I, K20R, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LF
 2142_20072142_2007JQ083042None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LF
Fokam (2011)CIRCB-10155CIRCB-10155JQ796127None   L10IV, K20R, E35D, M36I, R41K, D60E, I62V, L63P, I64IV, H69Q, I93LF
Santos (2011)J169J169_PRJN010564None   I15V, L19I, E35D, M36I, P39T, R41K, R57K, Q61N, H69K, L89M, I93LF
 J171J171_PRJN010566None   G17E, E35D, M36I, R41K, R57K, Q61N, L63T, K70R, I72T, V77I, L89M, I93LF
 J193J193_PRJN010597None   T12E, K14R, E35D, M36I, R41K, R57K, Q61N, L63S, I64L, I72T, L89M, I93LF
Afonso (2012)ANG110ANG110JN937114None   E35D, M36I, R41K, R57K, L63T, E65D, L89M, I93LF
Caron (2012)Gab082183Gab082183HQ541936None   L10V, T12N, I15V, K20R, E35D, M36I, R41K, I62V, L63S, L89M, I93LF
Alcantara (2013)BRGO4183BRGO4183JN114223None   L10V, K14R, I15V, G16GE, L19I, E35D, M36I, P39Q, R41K, Q61N, L63T, E65D, I72T, V77X, I93LF
Alencar (2013)SP2-0029SP2-0029JQ238090None   I15V, K20R, M36I, P39Q, R41K, R57K, Q61N, L63LI, L89M, I93LF
 PE2-0086PE2-0086JQ238175None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, L89M, I93LF
Bila (2013)MZ10-159HIV-1KF927264None   I13IV, L19I, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, I93LF
Ferreira (2013)BR09SP188BR09SP188HM533988None   L10V, I15IV, G17E, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63T, E65EK, I72IV, R87RK, I93LF
 BR09SP191BR09SP191HM534109None   I3V, L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, L63C, I72V, V77VI, I93LF
 BR09SP281BR09SP281HM534144None   L10IV, T12N, I15V, M36I, R41K, Q61N, L63V, V75VI, I93LF
 BR09SP352BR09SP352HM534178None   T12N, I15V, L19I, E35D, M36I, R41K, R57RK, Q61D, L89LM, I93LF
 BR09SP362BR09SP362HM534188None   L10V, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, I72T, L89M, I93LF
Frentz (2013)EHR-05034EHR-05034JX299627None   L10V, I15V, E35D, M36I, P39S, R41K, R57K, Q61D, L63T, H69Y, I72T, L89M, I93LF
 EHR-27715EHR-27715JX300019None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LF
Temereanca (2013)SR41SR41JX966517None   I15V, E35D, M36I, R41K, R57K, L63A, E65D, L89M, I93LF
 SR8SR8JX966534None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61H, L63T, E65D, I72T, L89M, I93LF
Agyingi (2014)LB034LB034KF576486None   I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69Q, L89M, I93LF
 LB002LB002KF576511None   I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69Q, L89M, I93LF
Niculescu (2014)DU1099DU1099KJ194752None   L10V, K14IT, I15V, L19T, K20R, E35DN, M36I, R41K, R57K, I62V, L63T, E65N, I72V, T74S, L89M, I93LF
Velasco-de-Castro (2014)05BRRJLTS14805BRRJLTS148KF922012None   T12P, K14R, R41K, R57K, Q61N, L63P, T74S, V77I, L89M, I93LF
 05BRRJLTS22405BRRJLTS224KF922037None   T12D, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63A, I64M, L89M, I93LF
Alexiev (2015)11BG124511BG1245KJ765471None   T12N, K14R, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61D, L63T, E65D, I72T, I93LF
Carvalho (2015)154154KM205924None   L10I, T12N, I15V, G17E, K20R, M36I, R57K, Q61H, L63T, L89M, I93LF
de Lourdes Teixeira (2015)9RJ1201709RJ120170 None   E35D, M36I, R41K, K43R, R57K, Q61N, V77I, L89M, I93LF
 9RJ1100709RJ110070 None   L10I, G16E, L19LI, E35D, M36I, R57K, D60E, Q61N, L63T, I72T, V77VI, L89M, I93L, G94NF
 7RJ1102197RJ110219 None   I15V, E35D, R41K, R57K, Q61N, I64M, H69HY, I72T, V82I, L89M, I93LF
Delgado (2015)X3124X3124KJ883091None   L10IV, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, L89M, I93LF
 X3567X3567KJ883127None   L10V, I13V, G16E, E35D, M36I, N37NK, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, L89M, I93LF
 X2902X2902KJ883089None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, K45KR, R57K, D60E, Q61N, I62V, H69Y, I72T, L89M, I93LF
 X3506X3506KJ883112None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, L89M, I93LF
 X3369X3369KJ883106None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, L89M, I93LF
 X3598X3598KJ883129None   L10IV, T12TS, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61DN, L63T, H69Y, I72T, L89M, I93LF
 X3744X3744KJ883135None   L10I, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62IV, H69Y, I72T, L89M, I93LF
Guimaraes (2015)BRSP594-14BRSP594-14KP115546None   E35D, M36I, R41K, R57K, D60E, Q61D, L63LP, V77I, L89M, I93LF
 BRSP786-14BRSP786-14KP115567None   E35D, R41K, R57K, Q61N, L63C, I64M, H69Y, V77I, L89M, I93LF
Moura (2015)BRMA_215BRMA_215KF782738None   L10V, I13V, E35D, M36I, N37D, R41K, K45R, R57K, D60E, Q61N, L63T, H69Y, I72T, V77I, L89M, I93LF
Tongo (2015)BS72BS72KR017779None   L10V, T12S, I15E, L19I, K20R, M36I, R41K, D60E, I62V, H69Q, V75I, L89M, I93LF
Castley (2016)P149605128LP149605128LKT229110None   K14R, N37S, I62V, L63P, G68E, H69R, V77I, I93LF
Delatorre (2016)13BRRJGN6313BRRJGN63KX357281None   T12S, K14N, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, V77I, L89M, I93LF
 12BRRJGN1512BRRJGN15KX357233None   T12LS, K14KT, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, V77I, L89M, I93LF
 12BRRJGN0312BRRJGN03KX357221None   T12S, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, V77I, R87RK, L89M, I93LF
Dos Anjos Silva (2016)AP103AP103KT737358None   L10V, T12A, K14R, I15V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63A, I72T, V77I, L89M, I93LF
 AP111AP111KT737364None   T12P, I15V, G16E, M36I, R41K, R57K, Q61N, L63T, I64M, E65D, G68GR, I72T, L89M, I93LF
 AP086AP086KT737342None   T12P, G16E, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, I62V, E65D, I72T, V77I, L89M, I93LF
 AP069AP069KT737327None   K14R, I15V, M36I, R41K, R57K, Q61N, L63T, E65D, I72A, L89M, I93LF
Hoenigl (2016)M1115283M1115283KU574308None   L10V, T12P, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LF
 M1418817M1418817KU574389None   L10V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LF
Lima (2016)08PE09108PE091KX020974None   L10I, I15V, E35D, M36I, N37D, R41K, Q61N, L89M, I93LF
 08PE08008PE080KX020985None   L10V, T12I, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63C, I72T, I93LF
 09PE21109PE211KX020960None   I15V, E35D, M36I, R41K, R57K, Q61N, L89M, I93LF
 08PE06208PE062KX021018None   L10I, T12N, I15V, G16E, E35D, M36I, P39Q, R41K, R57K, Q61D, L63S, I72V, L89M, I93LF
 08PE09908PE099KX021016None   L10V, I13M, I15V, E35D, M36I, R41K, D60E, Q61N, I62V, L89M, T91I, I93LF
 08PE08108PE081KX020973None   T12Q, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, E65D, V77I, L89M, I93LF
Pessoa (2016)10BR_SP02910BR_SP029KT427814None   I15V, K20R, M36I, P39Q, R41K, R57K, Q61N, L89M, I93LF