<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 35
Isolates 35
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Brindeiro (2002)TVGG27TVGG27AY145828RTV, NFV30I54V, V82A, L90M L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, L89IF
de Sa Filho (2003)BREPM132BREPM132AY182818IDV I54V, V82A L33V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, G68E, L89IF
Gomez-Carrillo (2004)113812113812AY365885PINAM46L, I54V, V82A L10LV, I15V, K20KR, E35D, M36I, R41K, R57K, Q61D, I62V, A71AV, L89I, I93LF
Machado (2004)cs189cs189AY313357NFV48L90M I15V, K20T, E35D, M36I, N37D, P39Q, R41K, R57K, D60E, Q61D, L89IF
Machado (2004)CS172proCS172proAY502095Unknown, NFV>21M46LN83DG16E, M36L, N37K, R41K, R57K, Q61D, I72R, L89IF
Non-B Workgroup (2005)BR38BR38AY900880NFV50L90M I15V, K20T, E35D, M36I, N37D, P39Q, R41K, R57K, D60E, Q61D, L89IF
 PL23900101500 Unknown, LPV>58I54V, V82AL33F, N83DL10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, T74S, L89IF
 PL36995591 Unknown, LPV>112M46L, G48V, I54V, V82A, L90ML33F, K43TL10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93LF
Rodrigues (2005)BLF_Pat5BR03SP147AY643162Unknown, IDV>256I54V, V82A L10I, I13V, I15V, G17E, K20I, E35D, M36I, R41K, R57K, Q61N, L63R, E65D, T74S, L89IF
 BLF_Pat8BR03SP01AY643156Unknown, RTV, IDV>51M46L, I54A, V82AL24I, K43TL10I, I15V, L19I, K20R, E35D, M36I, K55R, R57K, Q61N, L63P, A71V, I85V, L89IF
 BLF_Pat11BR03SP43AY643175IDV, Unknown, SQV, RTV, NFV>246I54V, V82A, L90M T12M, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, Q61H, I62V, H69R, T74S, L89I, C95CFF
 BLF_Pat17BR02SP88AY643155SQV, IDV, RTV, NFV, LPV285M46L, I50V, I54V, V82T, L90MK43TL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, L89I, Q92KF
 BLF_Pat21BR02SP235AY643144IDV, Unknown>165I54V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63V, A71V, I72T, L89I, Q92K, I93LF
 BLF_Pat34BR02SP220AY643141NFV111L90M K20RT, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, L89I, I93LF
 BLF_Pat35BR03SP71AY643177IDV, NFV269I54V, L90M L10V, I13V, I15V, K20T, E35D, M36I, N37T, R41K, R57K, Q61N, A71T, T74S, L89IF
Baxter (2006)48-32703270-30703DQ878175PINAM46L, I54V, V82A, L90MF53FLL10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, L89I, I93LF
 48-62856285-30924DQ878833PINAI54V, V82T, I84V T4TS, L10V, I13V, I15V, Q18M, L19Q, K20R, E35D, M36I, N37D, R41K, Q61N, A71V, L89IF
 48-92729272-30922DQ877288PINAM46L, I54V, V82A, L90LM L10I, I15V, L19Q, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, T74A, L89I, I93LF
 48-93499349-30923DQ877289PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89IF
 48-91869186-30901DQ877291PINAM46L, I54V, V82AL24I, L33F, K43T, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93LF
 48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
 48-91969196-30903DQ877572PINAM46I, I50V, I54V, V82AL33I, L76M, N83DL10V, T12E, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72T, T74S, L89IF
Dumans (2009)RENA181RENA181FJ405173IDV213M46L, I54V, V82AL24IL10I, I15V, E35D, M36I, P39T, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, L89I, I93LF
 RENA390RENA390FJ405175NFV205L90M I13V, I15V, K20R, E35D, M36I, N37E, P39Q, R41K, R57K, Q61N, I62V, L63P, T74S, L89I, I93LF
Sanabani (2010)81207BR_FPS812HM026460PINA  I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, L89IF
Aulicino (2011)ARL622bisBCNARL622bisBCNFJ525815PINAI54V, V82AN83DL10V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I72R, L89I, I93LF
 ARN815QLSARN815QLSFJ525866PINAI54V, L90M I13V, I15V, K20T, E35D, M36I, P39Q, R57K, Q61N, L63P, A71T, V82I, L89I, Q92K, I93LF
 96-N422ELE96-N422ELEHQ158177PINA  T12D, I15V, L19I, K20R, M36I, R41K, K55R, R57K, Q61D, I72T, L89IF
Jones (2012)130315130315JN669484PINAL90M L10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, L89IF
 130542130542JN669493PINAI54V, V82A, I84VF53LT4TS, L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 132888132888JN669516PINAM46L, I54V, V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I62V, A71V, I72T, L89I, I93LF
 155976155976JN669848PINAL90M T12M, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I72T, V82I, L89I, I93LF
 182974182974JN670630PINA  T12D, I15V, Q18L, L19I, E35D, M36I, R41K, K45R, K55KR, R57K, Q61N, L63LP, I72AMTV, L89IF
 183349183349JN670642PINAM46L, I54V, L76V, V82A L10I, T12I, I15V, G16E, L19I, K20M, E35DN, M36I, R41RK, R57K, Q61N, L63LH, I85V, L89IF
 205791205791JN671372PINAI54V, I84V, L90M L10I, I13IV, I15V, Q18K, K20M, E35D, M36I, R41K, Q61N, I62V, L63P, I66IV, T74A, L89IF