<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation I85V
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 77
Isolates 77
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Dumans (2004)242242AY390086NFV177D30N, M46IN88DL10V, I13V, R41K, R57K, D60E, Q61D, I64V, V77I, I85VF
Gomez-Carrillo (2004)9297792977AY365483PINAI54A, V82A L10I, T12P, I15V, K20R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, A71V, I85V, I93LF
 9702297022AY365539PINAI54V, V82T, L90M L10I, T12TP, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I85V, I93LF
 103279103279AY365676PINAM46I, I54S, V82AL24I, K43TL10I, T12P, I15V, L19I, K20M, E34K, E35D, M36I, R57K, Q61N, L63V, I64V, I72T, T74S, I85VF
 104518104518AY365706PINAM46ML, I54V, V82C, L90M L10I, I15V, K20R, E35D, M36I, N37V, R41RK, K55N, R57K, D60E, Q61N, I62V, L63P, A71T, I72T, I85V, I93LF
 105044105044AY365715PINAI54V, V82A L10I, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I85V, I93LF
 105247105247AY365720PINAI54V, V82A, L90M L10I, T12N, I15V, K20I, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, E65D, A71V, I85V, I93LF
 105960105960AY365740PINAI54V, V82A, L90M L10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63P, A71V, I72T, I85V, I93LF
 110390110390AY365836PINAI54ML33F, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I85VF
 112319112319AY365857PINAM46I, I54V, V82F L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I72T, I85V, I93LF
 113771113771AY365884PINAI47V, I54M, L90M L10I, I13IV, I15V, K20I, E35DN, M36I, R41K, R57K, Q61N, L63P, T74S, V82VI, I85VF
 118746118746AY365953PINAM46I, I54V, I84V, L90MV11I, G73SL10I, I15V, L19P, K20I, E35D, M36I, R57K, Q61H, L63P, A71V, I72T, I85V, I93LF
 120047120047AY365976PINAI54V, V82A, L90M L10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63P, A71V, I72T, I85V, I93LF
 122743122743AY366014PINAV32I, M46I, I47A T12TIM, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, I72T, V82I, I85VF
Rodrigues (2005)BLF_Pat8BR03SP01AY643156Unknown, RTV, IDV>51M46L, I54A, V82AL24I, K43TL10I, I15V, L19I, K20R, E35D, M36I, K55R, R57K, Q61N, L63P, A71V, I85V, L89IF
 BLF_Pat17BR02SP88AY643155SQV, IDV, RTV, NFV, LPV285M46L, I50V, I54V, V82T, L90MK43TL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, L89I, Q92KF
Baxter (2006)48-10941094-30728DQ877265PINAM46I, I54V, V82S, L90ML33F, K43T, G73SL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61D, L63P, A71V, I72T, I85V, I93LF
 48-11361136-30729DQ877275PINAM46I, I47V, I54V, V82FL33F, K43T, N88D, L89LVL10I, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, I85V, I93LF
 48-10071007-30609DQ877312PINAM46I, I47V, I54V, V82A, L90MF53LL10V, L19LI, K20R, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, I62V, L63LP, A71V, I85V, I93LF
 48-10901090-30717DQ877345PINAL90LM K14R, I15V, K20T, E35G, M36I, R41K, R57K, Q61N, A71T, I72T, T74TA, V82I, I85V, Q92QRF
 48-11961196-30924DQ877381PINAI54V, V82A, L90MF53LL10I, K20R, E35D, M36I, N37ND, R41K, D60E, Q61N, L63P, H69R, A71V, I85VF
 48-11801180-30922DQ877428PINAV32I, M46I, I47V, I54M, L90MF53LL10I, I15V, K20I, E35N, M36I, R41K, R57K, Q61N, L63P, I72IV, T74S, V82I, I85V, L89LIF
 48-26142614-30624DQ877904PINAM46L, I54V, V82AL33F, F53LL10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89MF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
Dumans (2009)59PR59PRFJ405165Unknown, NFV>27M46L, I54V, V82AL24IL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I85V, L89MF
 RENA626RENA626FJ405172IDV, SQV, RTV, NFV, LPV335M46L, I50V, I54V, V82T, L90MK43T, L89VL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, Q92KF
Sanabani (2009)56406BR564FJ771008PINAM46L, V82AK43TL10M, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, I85V, L89TF
Aulicino (2011)ARL162MJMARL162MJMFJ525806PINAM46L, I54V, V82A, L90M L10I, I15V, K20I, E35D, M36I, N37D, R41K, W42W*, K55R, R57K, Q61N, L63P, A71V, I72T, T74S, I85V, I93LF
 ARM804TJXARM804TJXFJ525841PINAD30NN88DT12M, I15V, K20T, E35D, M36I, R41K, K45R, R57K, Q61D, A71T, I72T, T74S, I85VF
Jones (2012)130542130542JN669493PINAI54V, V82A, I84VF53LT4TS, L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 138373138373JN669571PINA  L10I, I15V, L19Q, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63P, I72T, V82I, I85V, I93LF
 139712139712JN669580PINAI54V, V82VL, L90ML89LVL10I, I15V, K20T, E35DN, M36I, N37D, R41K, R57K, Q61DN, I64IV, T74S, I85V, I93LF
 148773148773JN669723PINAM46L, I54V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I85V, I93LF
 150202150202JN669745PINAI54V, L90MG73SL10I, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, I72R, I85VF
 153757153757JN669806PINAM46L, I54V, V82AK43TL10I, I15V, G17E, K20M, E35D, M36I, N37K, R57K, Q61D, L63P, I72R, I85V, I93LF
 157416157416JN669883PINAM46I, I50V, I54V, L76V, V82A, L90LMQ58E, L89VL10I, I15V, K20R, E35D, M36I, R41K, K55KR, R57RK, D60E, Q61N, I62V, L63P, A71V, G73DE, I85V, Q92K, I93LF
 158556158556JN669924PINAM46I, I54V, V82T, L90M L10LI, I15V, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, I85V, I93LF
 159510159510JN669955PINAI54V, V82A, L90MK43TL10I, I15V, G16E, K20M, E35D, M36I, R41R_R, R57K, Q61N, I62L, L63C, A71T, I72T, T74S, I85VF
 163933163933JN670073PINAM46I, I47V, I54V, V82F, L90ML89VL10I, I15V, G17D, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, I62V, L63P, T74S, V77I, I85V, I93LF
 167784167784JN670162PINAM46L, I54V, V82F, L90MG48EL10I, T12N, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, I64IV, T74S, I85V, I93LF
 171320171320JN670254PINAI54V, L90MG73SL10I, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, I72R, I85VF
 172778172778JN670302PINAI54V, L76V, V82A L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I72T, I85V, I93LF
 177489177489JN670445PINAI54V, V82T, I84VL33IL10V, I13V, I15V, K20R, E34ED, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64V, A71V, T74S, P79A, I85V, I93LF
 183035183035JN670635PINAI54V, V82A, L90ML33F, N88DL10I, I15V, K20R, E35D, M36I, N37ND, R41K, K45R, R57K, Q61N, L63P, A71V, I72T, I85V, I93LF
 183349183349JN670642PINAM46L, I54V, L76V, V82A L10I, T12I, I15V, G16E, L19I, K20M, E35DN, M36I, R41RK, R57K, Q61N, L63LH, I85V, L89IF
 184896184896JN670689PINAM46I, I54V, V82T, I84V, L90ML33F, Q58EL10V, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V, I85V, L89M, I93LF
 199633199633JN671178PINAD30N, M46IF53FL, N88DL10X, I13IV, I15AV, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, A71V, T74S, I85V, I93LF
 203975203975JN671325PINAM46ML, I54V, V82A, L90ML33F, G73SL10I, I15V, K20T, E35N, M36I, N37DE, R41K, R57K, Q61N, L63P, A71V, I72R, I85VF
 205464205464JN671362PINAM46I, I54V, V82T, L90MV11I, G73SL10I, K14R, I15V, L19P, K20I, E21D, E35NS, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63P, A71V, T74S, I85V, I93LF
 205530205530JN671366PINAI54V, V82T L10I, I15V, K20M, E35D, M36I, R41K, K45R, R57K, Q61N, L63P, T74S, I85V, I93LF
Diaz (2015)RenG17168RenG17168KT748196PINAV32I, I47A, I50VN83NDL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, V82I, I85V, L89IF
 RenG15688RenG15688KT746716PINAN88S L10I, I15V, K20T, E35D, M36I, P39Q, R41K, R57K, Q61N, L63A, A71T, I85VF
 RenG17347RenG17347KT748375PINAL90M L10V, T12I, I15V, G16Q, K20T, E35D, M36I, P39Q, R41K, K45R, R57K, Q61N, A71V, I72T, V77I, I85V, L89T, I93LF
 RenG16531RenG16531KT747559PINAM46L, I54V, I84V, L90MG73SL10I, K20I, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I85V, L89T, Q92KF
 RenG16813RenG16813KT747841PINAI54V, I84VG73SL10I, K20I, E35N, M36I, R41K, K45R, R57K, Q61N, A71V, I72V, I85V, L89T, Q92QRF
 RenG16719RenG16719KT747747PINAM46I, I50V I15V, G16GE, K20T, E35D, M36I, R41K, K55R, R57K, Q61N, L63H, V82I, I85V, I93LF
 RenG17332RenG17332KT748360PINAV32I, M46L, I47V, V82FF53LL10I, K20R, E35D, M36I, N37S, R41K, R57K, Q61N, L63T, E65D, A71I, I72T, V77I, I85V, I93LF
 RenG17228RenG17228KT748256PINAM46MI, I47IV, I54V, V82A L10V, T12TN, I15V, L19IM, K20R, E35D, M36I, R41K, K45KR, R57K, Q61N, L63P, A71I, T74TS, I85V, L89T, I93LF
 RenG16860RenG16860KT747888PINAV32I, M46I, I47IV, I54IV, V82AK43TL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61DE, L63H, I85V, L89IF
 RenG14829RenG14829KT745857PINAN88SL33I, Q58EL10I, T12E, I15V, E35N, M36I, P39Q, R41K, R57K, D60E, Q61D, L63Q, I85V, L89MF
 RenG15110RenG15110KT746138PINAG48GA, I50IL, I54V, V82AT, L90ML33LI, F53FLL10I, T12K, I15V, L19P, K20V, E35D, M36I, N37NT, R41K, R57RK, Q61N, H69HR, K70KQ, A71AITV, T74S, V77VI, I85V, L89I, I93ILF
 RenG13750RenG13750KT744778PINAM46I, G48V, I50V, I54T, V82AL33FL10I, I15V, K20R, E34N, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, I85V, L89I, I93LF
 RenG14185RenG14185KT745213PINAG48V, I54V, V82S L10IV, I15V, G16E, K20I, E35D, M36I, N37DE, R41K, R57K, Q61N, I62L, L63N, A71IT, T74S, I85V, Q92KF
 RenG14415RenG14415KT745443PINAM46ML, I54L, L90ML23LI, F53LL10IV, I15V, G16E, K20T, E35D, M36V, P39PS, R41K, R57K, Q61N, L63T, A71AV, I72T, T74S, I85V, L89IM, I93LF
 RenG15101RenG15101KT746129PINAM46I, I54S, V82A, L90ML33I, K43TL10I, K14T, I15V, L19V, K20R, E35D, M36I, N37D, K55R, Q61N, T74S, I85V, L89IF
 RenG14046RenG14046KT745074PINAI47V, G48A, I54A, V82AS L10I, I15V, G16GE, K20R, E35D, M36I, N37ND, R41K, K43KR, K45KR, R57K, Q61N, L63Q, A71V, I85V, L89I, Q92K, I93LF
 RenG13959RenG13959KT744987PINAD30N, L90ML33LI, N88DL10Y, I15V, K20T, E35DN, M36I, N37D, R41K, R57K, Q61N, I62V, A71T, T74S, V77I, I85V, L89T, Q92QKRF
 RenG12818RenG12818KT743846PINAV32I, I47AV, I50L I15V, K20T, E35D, M36I, R41K, R57K, Q61S, K70R, A71V, V82I, I85V, L89IF
 RenG12368RenG12368KT743396PINAM46I, I54V, L76VG73SL10V, I15V, L19V, E35D, M36I, R41K, R57K, D60E, I62L, A71IV, V77I, I85V, L89T, Q92KF
 RenG13089RenG13089KT744117PINAM46I, I54V, L76V, V82L L10I, T12N, I15V, L19I, K20T, D25DN, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, A71I, V77I, I85V, L89T, Q92KF
 RenG11775RenG11775KT742803PINAM46L, I54V, L76LV, V82A, L90M L10V, K14R, I15V, G16E, K20MT, E35N, M36I, N37D, R41K, K55KR, R57K, Q61N, I62IV, L63HP, T74S, V77VI, I85V, L89I, I93LF
 RenG11600RenG11600KT742628PINAM46I, I54L, V82A, I84VL24I, L33FL10I, I13V, I15V, K20R, E35D, M36I, R41K, K43I, R57K, Q61N, I62V, I72T, I85V, L89M, T91SF
 RenG10777RenG10777KT741805PINA F53L, N88TK14R, I15V, L19I, K20T, E35D, M36I, R41K, R57K, Q61N, A71V, I85V, L89TF
 RenG11029RenG11029KT742057PINAV32IQ58EW6WG, L10V, T12P, K14R, I15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, G68E, A71V, I85V, L89TF
 RenG11506RenG11506KT742534PINAM46I, I50L, V82A, L90LMG73GSL10V, I15V, Q18QE, K20R, E35D, M36I, K45R, K55R, R57K, Q61N, L63P, A71IV, I85V, I93LF
 RenG10503RenG10503KT741531PINAM46L, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, K55R, L63P, I85V, L89M, I93LF
 RenG11078RenG11078KT742106PINAG48V, I50L, I54V, V82A L10V, K14R, I15V, L19V, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, G68D, A71AT, I85V, L89IF