<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation I85V
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 45
Isolates 45
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Dumans (2004)242242AY390086NFV177D30N, M46IN88DL10V, I13V, R41K, R57K, D60E, Q61D, I64V, V77I, I85VF
 RES075RES075AY390202IDV, SQV, NFV, RTV, APV, Unknown>317I54IV L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63LP, T74TA, V82I, I85V, L89M, I93ILF
Gomez-Carrillo (2004)113771113771AY365884PINAI47V, I54M, L90M L10I, I13IV, I15V, K20I, E35DN, M36I, R41K, R57K, Q61N, L63P, T74S, V82VI, I85VF
Rodrigues (2005)BLF_Pat8BR03SP01AY643156Unknown, RTV, IDV>51M46L, I54A, V82AL24I, K43TL10I, I15V, L19I, K20R, E35D, M36I, K55R, R57K, Q61N, L63P, A71V, I85V, L89IF
 BLF_Pat17BR02SP88AY643155SQV, IDV, RTV, NFV, LPV285M46L, I50V, I54V, V82T, L90MK43TL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, L89I, Q92KF
Baxter (2006)48-11681168-30911DQ877356PINAI54V, V82A, I84VF53LL10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 48-26142614-30624DQ877904PINAM46L, I54V, V82AL33F, F53LL10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89MF
 48-92789278-30924DQ877616PINAM46I, I47V, I54L, V82A, L90MK43T, F53L, G73C, L89VL10V, I15V, G16E, Q18H, K20M, E34Q, M36I, P39S, K55R, D60E, I62V, L63P, I85VF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
Waleria-Aleixo (2008)08PR06054608PR060546FJ591462PINAI54V, V82A, L90MF53LL10V, T12I, I15V, G16E, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I66M, K70KR, A71T, I72T, I85V, L89I, Q92K, C95VF
 08RJ04011108RJ040111FJ591595PINAI54LV, I84V, L90ML33F, G73SL10I, K14R, G16E, K20R, E35D, M36I, P39S, R41K, K45R, R57K, Q61N, I62V, L63P, C67F, A71V, I72T, I85V, Q92KF
 RES211RES211FJ591934PINAV32I, V82A, L90M L10LI, I15V, K20R, E35D, M36I, N37ND, R41K, K43R, R57K, Q61N, I62V, L63A, A71V, I85V, Q92KF
 08PR05031308PR050313FJ591341PINAM46L, L90ML33F, G73GAL10V, I13IV, I15V, K20T, E35D, M36I, R41K, K55KR, R57K, Q61N, L63P, E65ED, C67CY, A71T, I72T, I85VF
Dumans (2009)59PR59PRFJ405165Unknown, NFV>27M46L, I54V, V82AL24IL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I85V, L89MF
 RENA626RENA626FJ405172IDV, SQV, RTV, NFV, LPV335M46L, I50V, I54V, V82T, L90MK43T, L89VL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, Q92KF
Sanabani (2009)56406BR564FJ771008PINAM46L, V82AK43TL10M, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, I85V, L89TF
Jones (2012)130542130542JN669493PINAI54V, V82A, I84VF53LT4TS, L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 173669173669JN670342PINAM46I, I47V, I54V, I84V, L90MV11I, G73SL10I, I15V, G17E, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, I72R, I85VF
 183349183349JN670642PINAM46L, I54V, L76V, V82A L10I, T12I, I15V, G16E, L19I, K20M, E35DN, M36I, R41RK, R57K, Q61N, L63LH, I85V, L89IF
 183778183778JN670660PINAL90M L10I, I15V, K20V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, T74S, I85V, Q92KF
Diaz (2015)RenG17168RenG17168KT748196PINAV32I, I47A, I50VN83NDL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, V82I, I85V, L89IF
 RenG17347RenG17347KT748375PINAL90M L10V, T12I, I15V, G16Q, K20T, E35D, M36I, P39Q, R41K, K45R, R57K, Q61N, A71V, I72T, V77I, I85V, L89T, I93LF
 RenG16531RenG16531KT747559PINAM46L, I54V, I84V, L90MG73SL10I, K20I, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I85V, L89T, Q92KF
 RenG16813RenG16813KT747841PINAI54V, I84VG73SL10I, K20I, E35N, M36I, R41K, K45R, R57K, Q61N, A71V, I72V, I85V, L89T, Q92QRF
 RenG17332RenG17332KT748360PINAV32I, M46L, I47V, V82FF53LL10I, K20R, E35D, M36I, N37S, R41K, R57K, Q61N, L63T, E65D, A71I, I72T, V77I, I85V, I93LF
 RenG17228RenG17228KT748256PINAM46MI, I47IV, I54V, V82A L10V, T12TN, I15V, L19IM, K20R, E35D, M36I, R41K, K45KR, R57K, Q61N, L63P, A71I, T74TS, I85V, L89T, I93LF
 RenG16860RenG16860KT747888PINAV32I, M46I, I47IV, I54IV, V82AK43TL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61DE, L63H, I85V, L89IF
 RenG14829RenG14829KT745857PINAN88SL33I, Q58EL10I, T12E, I15V, E35N, M36I, P39Q, R41K, R57K, D60E, Q61D, L63Q, I85V, L89MF
 RenG15110RenG15110KT746138PINAG48GA, I50IL, I54V, V82AT, L90ML33LI, F53FLL10I, T12K, I15V, L19P, K20V, E35D, M36I, N37NT, R41K, R57RK, Q61N, H69HR, K70KQ, A71AITV, T74S, V77VI, I85V, L89I, I93ILF
 RenG13750RenG13750KT744778PINAM46I, G48V, I50V, I54T, V82AL33FL10I, I15V, K20R, E34N, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, I85V, L89I, I93LF
 RenG14415RenG14415KT745443PINAM46ML, I54L, L90ML23LI, F53LL10IV, I15V, G16E, K20T, E35D, M36V, P39PS, R41K, R57K, Q61N, L63T, A71AV, I72T, T74S, I85V, L89IM, I93LF
 RenG15101RenG15101KT746129PINAM46I, I54S, V82A, L90ML33I, K43TL10I, K14T, I15V, L19V, K20R, E35D, M36I, N37D, K55R, Q61N, T74S, I85V, L89IF
 RenG13694RenG13694KT744722PINAV32I, I47V, G48V, I54V, V82A, L90ML33F, F53L, Q58E, L89VL10I, I13V, K14E, I15V, K20R, E34Q, E35D, M36I, N37D, R41K, K55R, V56I, R57K, D60E, I62V, L63P, A71V, I85V, Q92KF
 RenG14046RenG14046KT745074PINAI47V, G48A, I54A, V82AS L10I, I15V, G16GE, K20R, E35D, M36I, N37ND, R41K, K43KR, K45KR, R57K, Q61N, L63Q, A71V, I85V, L89I, Q92K, I93LF
 RenG13959RenG13959KT744987PINAD30N, L90ML33LI, N88DL10Y, I15V, K20T, E35DN, M36I, N37D, R41K, R57K, Q61N, I62V, A71T, T74S, V77I, I85V, L89T, Q92QKRF
 RenG14896RenG14896KT745924PINAM46I, I47V, I54V, V82FL33F, K43ITL10V, I13V, K20R, E35D, M36I, R41X, D60DE, Q61D, E65D, I72T, I85V, L89MF
 RenG12818RenG12818KT743846PINAV32I, I47AV, I50L I15V, K20T, E35D, M36I, R41K, R57K, Q61S, K70R, A71V, V82I, I85V, L89IF
 RenG12368RenG12368KT743396PINAM46I, I54V, L76VG73SL10V, I15V, L19V, E35D, M36I, R41K, R57K, D60E, I62L, A71IV, V77I, I85V, L89T, Q92KF
 RenG13089RenG13089KT744117PINAM46I, I54V, L76V, V82L L10I, T12N, I15V, L19I, K20T, D25DN, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, A71I, V77I, I85V, L89T, Q92KF
 RenG11775RenG11775KT742803PINAM46L, I54V, L76LV, V82A, L90M L10V, K14R, I15V, G16E, K20MT, E35N, M36I, N37D, R41K, K55KR, R57K, Q61N, I62IV, L63HP, T74S, V77VI, I85V, L89I, I93LF
 RenG11600RenG11600KT742628PINAM46I, I54L, V82A, I84VL24I, L33FL10I, I13V, I15V, K20R, E35D, M36I, R41K, K43I, R57K, Q61N, I62V, I72T, I85V, L89M, T91SF
 RenG10777RenG10777KT741805PINA F53L, N88TK14R, I15V, L19I, K20T, E35D, M36I, R41K, R57K, Q61N, A71V, I85V, L89TF
 RenG11029RenG11029KT742057PINAV32IQ58EW6WG, L10V, T12P, K14R, I15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, G68E, A71V, I85V, L89TF
 RenG10503RenG10503KT741531PINAM46L, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, K55R, L63P, I85V, L89M, I93LF
 RenG11078RenG11078KT742106PINAG48V, I50L, I54V, V82A L10V, K14R, I15V, L19V, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, G68D, A71AT, I85V, L89IF