<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation V77I
Rx PI-naive
IncludeMixtures No
References 43
Patients 88
Isolates 89
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Tanuri (1999)BRAM-29BRAM-29AF076448None   T12M, E35D, M36I, R41K, R57Q, D60E, Q61N, K70R, V77I, I85N, L89MF
 BR60BR60AF079989None   E35D, M36I, R41K, R57K, Q61N, V77I, L89MF
Carr (2001)ARMA159ARMA159AF385936None   T12I, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, V77I, I93LF
Kijak (2001)ARG28ARG28PRAF328586None   I15V, E35D, M36I, R41K, R57K, D60E, Q61D, I64IV, V77I, I93LF
Fonjungo (2002)CM223CM223AY051202None   L10V, I15V, L19I, K20R, E35D, M36I, R41K, R57K, V77I, L89M, I93LF
Brindeiro (2003)BRCN31BRCN31AY213321None   E35D, M36I, R41K, R57K, Q61N, V77I, L89M, C95SF
 BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRSP364BRSP364AY213196None   K14R, Q18L, E35D, M36I, R41K, R57K, Q61N, L63C, I72T, V77I, L89M, I93LF
 BRNE132BRNE132AY213326None   I15V, E35D, M36I, R41K, R57K, D60E, Q61D, V77I, L89M, I93LF
Soares (2003)BRRJ820BRRJ820AF527326None   K14R, I15V, M36I, R41K, K45R, R57K, Q61N, L63A, C67D, I72T, V77I, C95SF
 BRRJ853BRRJ853AF527346None   T12V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, V77I, L89M, C95SF
Gulick (2004)RG21RG21w0 None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, K45R, R57K, L63T, E65D, V77I, L89MF
 RG5RG5w0 None  V11VIL10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, V77I, I93LF
Konings (2004)KF_Pat1601CM5149AY359698None   L10I, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, V77I, L89MF
Machado (2004)cs272cs272AY569835None   L10I, E35D, M36I, R41K, R57K, D60E, Q61D, V77IF
 N75N75AY569900None   E35D, M36I, R41K, R57K, D60E, Q61D, L63P, H69Y, I72T, V77IF
Machado (2004)cs138cs138AY313304None   K14R, I15V, E35D, M36I, R41K, R57K, Q61N, V77I, L89M, C95SF
 cs139cs139AY313305None   T12D, K14R, I15V, G16E, L19T, E35D, M36I, P39Q, R41K, R57K, Q61N, L63V, I72T, V77I, L89M, C95SF
 cs156cs156AY313310None   L10V, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, L63S, I72V, V77IF
 cs157cs157AY313311None   L10V, E35D, M36I, R41K, Q61N, L63S, E65D, V77I, L89MF
Non-B Workgroup (2005)BR36BR36AY900876None   Q2P, L10V, E35D, M36I, R41K, Q61N, L63S, V77I, L89MF
Rodrigues (2005)BR04813100AY643181None   T12N, I15V, E35D, R41K, R57K, Q61N, E65D, C67CW, A71AG, I72V, V77I, L89MF
de Sa Filho (2006)BREPM11948BREPM11948DQ085871None   L10I, E35D, M36I, R41K, R57K, Q61N, L63C, C67D, T74S, V77I, L89MF
Petroni (2006)AP_ARRP040AP_ARRP040DQ345496None   I15V, E35D, M36I, R41K, K45R, R57K, Q61N, L63S, V77I, I93LF
 AP_ARRP054AP_ARRP054DQ345503None   I15V, G17D, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, V77I, I93LF
Santos (2006)144144PR_RTAY275771None   E35D, N37D, R41K, I62V, L63P, V77I, L89M, I93LF
 RG018RG018DQ344018None   T12A, K14R, M36I, N37D, R57K, Q61N, V77I, L89M, G94X, L97*F
Dilernia (2007)F211F211EF120176None   T12S, I15V, L19V, E35D, M36I, R41K, R57K, D60E, Q61N, I64L, V77I, L89M, I93LF
 F271F271EF120204None   I15V, Q18E, E35D, R41K, R57K, Q61N, L63T, I72IT, V77I, I93ILF
 N19N19EF120280None   I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61D, V77IF
 N23N23EF120284None   I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61D, V77IF
 N41N41EF120300None   L10V, E35D, M36I, R41K, R57K, Q61N, V77I, I93LF
 F122F122EF120355None   I15V, E35D, R41K, R57K, Q61N, L63P, C67DEHQ, H69Y, V77I, L89LMF
Eyer-Silva (2007)BRSQ0505BRSQ05EF042629None   I15V, E35D, M36I, R41K, R57K, Q61N, L63C, V77I, V82I, L89M, I93LF
 BRSQ6905BRSQ69EF042667None   K14R, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63C, V77I, V82I, L89M, I93LF
Gonsalez (2007)30HIV_30GU288731None   T12S, E35D, M36I, R41K, R57K, D60E, Q61N, L63A, I64IM, V77I, L89MF
Paraschiv (2007)23012301_2004JQ082994None   L10V, T12S, I15V, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89MF
Sa-Filho (2007)BREPM1026BREPM1026EF637055None   L10V, K14R, I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, I62V, L63S, E65D, V77I, L89M, I93LF
Varella (2007)5ini5ini None   K14R, I15V, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, C67D, I72T, V77IF
 32ini32ini None   T12Q, I15V, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, H69Y, V77I, L89MF
Vicenti (2007)372750612REF376365None   I15V, E35D, M36I, R41K, R57K, Q61N, E65D, V77I, L89MF
von Wyl (2007)1001313047EF449815None   I13V, K20I, M36I, N37N_N, L63P, H69K, K70R, V77I, L89MF
Ndembi (2008)CMYD-3204CMYD-32DQ990403None   I13V, K20I, M36I, N37N_N, P39S, R41K, H69K, K70R, V77I, L89MF
Brown (2009)CAS_1341_4_1244CAS_1341_4_1244FJ030690None   I15V, E35D, M36I, R41K, R57K, Q61N, V77I, I93LF
Cardoso (2009)BRGO3010BRGO3010FJ548794None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, V77I, L89MF
 BRGO3042BRGO3042FJ548818None   G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61D, E65ED, V77I, L89MF
Cuevas (2009)P1273P1273.1EU822620None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, V77I, L89MF
de Sa-Filho (2009)5736757367IthGQ294625None  I47LL10V, I13V, I15V, E35A, M36I, R41K, R57K, Q61N, V77I, L89MF
Vercauteren (2009)pt11716161314874GQ399853None   L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, V77IF
 pt9797376165366GQ400045None   G16E, E35D, M36I, R41K, R57K, Q61N, L63AS, E65D, K70KR, V77I, L89MF
 pt8388126543316GQ400186None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89MF
 pt7908428524942GQ400234None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89MF
 pt6659017941016GQ400359None   L10V, I13V, I15V, G16GE, Q18QE, E35D, M36MI, R41K, R57K, Q61N, L63C, I72V, V77I, L89MF
Arruda (2010)105816CE081058JQ230646None   T12N, E35D, M36I, R41K, R57K, D60E, Q61N, V77I, L89M, I93LF
Castelbranco (2010)090026A090026AHM357745None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, V77I, L89MF
 090028A090028AHM357746None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89MF
Castro (2010)PHI-22PHI-22GQ131610None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, V77I, L89MF
Ferreira (2010)P49DIP49GQ862308None   L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, V77I, L89MF
 P8DIP8GQ862313None   E35D, M36I, R41K, R57K, Q61N, V77IF
Yang (2010)20106934792010693479JQ616904None   L10V, I13V, I15IV, G16E, E35D, M36I, R41K, L63T, E65D, I66V, I72T, V77I, L89MF
Aulicino (2011)309-A604309-A604HQ158207None   I15V, E35D, M36I, R41K, R57K, Q61D, L63Q, V77I, I93LF
 94-66194-661HQ158265None   T12A, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, V77I, I93LF
Carvalho (2011)O05-43O05-43GU214111None   I15V, G16E, E35D, N37K, R41N, R57K, D60E, Q61N, I64L, C67CW, H69K, V77I, L89M, I93LF
 O0766O0766HM583578None   K14R, I15V, G17E, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, I64L, H69Y, I72V, V77I, L89MF
Florea (2011)4148_20074148_2007JQ083055None   I15V, G16E, K20R, E35N, M36I, P39T, R41K, R57K, I62V, L63T, E65D, I72T, V77I, L89MF
Santos (2011)J78J78_PRJN010456None   G17E, E35D, M36I, R41K, R57K, Q61N, L63A, H69Y, I72T, V77I, L89MF
 J171J171_PRJN010566None   G17E, E35D, M36I, R41K, R57K, Q61N, L63T, K70R, I72T, V77I, L89M, I93LF
 J179J179_PRJN010580None   G17E, E35D, M36I, R41K, R57K, Q61N, L63T, K70R, I72T, V77IF
Alencar (2013)PE2-0004PE2-0004JQ237988None   I15V, L19I, E35D, M36I, R41K, Q61N, H69Y, K70R, I72T, V77I, L89MF
 RJ2-0013RJ2-0013JQ238011None   I13V, E35D, M36I, R41K, R57K, Q61N, E65D, I72T, V77I, L89MF
 RJ2-0070RJ2-0070JQ238142None   K14R, I15V, E35D, M36I, R41K, R57K, Q61N, I72T, V77I, L89MF
Billong (2013)MR040MR040KF192236None  I47ILI15V, K20R, E35D, M36I, N37ND, R41K, K45R, H69Q, V77I, L89MF
  MR040KF192237None   I15V, K20R, E35D, M36I, N37D, R41K, K45R, H69Q, V77I, L89MF
Ferreira (2013)BR09SP518BR09SP518HM534039None   I15V, E35D, M36I, R41K, R57K, Q61N, L63G, V77I, L89MF
 BR09SP534BR09SP534HM534040None   I15V, E35D, M36I, R41K, R57K, Q61N, L63G, V77I, I85M, L89MF
 BR09SP561BR09SP561HM534041None   I15V, E35D, M36I, R41K, R57K, Q61N, L63G, V77I, L89MF
 BR09SP73BR09SP73HM534056None   L10I, T12M, G16E, E35D, P39S, R41K, R57K, D60E, Q61N, L63T, E65D, K70KR, I72V, V77I, L89MF
 BR09SP92BR09SP92HM534075None   L10V, T12MV, G16E, E35D, M36I, P39S, R41K, R57K, D60E, Q61N, I62V, I72V, V77I, L89MF
 BR09SP173BR09SP173HM534092None   E35D, M36I, R41K, R57K, D60E, Q61N, I72IATV, V77I, L89MF
 BR09SP211BR09SP211HM534126None   E35D, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, I93LF
 BR09SP274BR09SP274HM534137None   I15V, G16GE, G17GE, E35D, M36I, R41K, R57K, Q61N, L63G, I72V, V77I, L89MF
 BR09SP339BR09SP339HM534167None   G16E, E35D, M36I, N37D, R57K, D60E, Q61N, I72IT, V77I, L89MF
 BR09SP351BR09SP351HM534177None   I13V, E35D, M36I, R41K, R57K, Q61N, V77I, L89MF
 BR09SP286BR09SP286HM534205None   I13V, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, L89MF
Frentz (2013)EHR-23013EHR-23013JX299937None   L10V, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, V77I, L89MF
 EHR-38978EHR-38978JX300203None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89M, Q92KF
 EHR-61454EHR-61454JX300566None   L10V, K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, H69Q, V77I, L89MF
 EHR-71780EHR-71780JX300753None   I15V, G16E, K20R, E35N, M36I, P39T, R41K, R57K, I62V, L63T, E65D, I72T, V77I, L89MF
Zeng (2013)cdbc27cdbc27KC352099None   K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, V77I, L89MF