<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation T74S
Rx PI-naive
IncludeMixtures No
References 20
Patients 44
Isolates 44
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Machado (2004)N47N47AY569882None   I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, I72T, T74SF
Arien (2005)VI64VI64DQ177219None   I15V, E35D, M36I, R41K, R57K, I62V, L63V, I72V, T74S, L89MF
Holguin (2005)0007110302_71103AY248334None   L10V, T12P, K14R, E35D, M36I, R41K, R57K, L63V, T74S, L89MF
de Sa Filho (2006)BREPM11948BREPM11948DQ085871None   L10I, E35D, M36I, R41K, R57K, Q61N, L63C, C67D, T74S, V77I, L89MF
Petroni (2006)AP_ARRP006AP_ARRP006DQ206649None   I15V, E35D, M36I, R41K, R57K, Q61N, L63C, T74SF
 AP_ARRP010AP_ARRP010DQ206650None   I15V, E35D, M36I, R41K, R57K, Q61S, I72V, T74S, L89MF
 AP_ARRP053AP_ARRP053DQ345502None   T12S, I15V, L19LGRV, K20R, E35D, M36I, R41K, R57K, Q61D, I72T, T74SF
Dilernia (2007)F313F313EF120224None   E35D, M36I, R41K, R57K, Q61N, I62V, T74SF
 N54N54EF120311None   T12A, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, T74SF
Paraschiv (2007)590590_2004JQ083007None   T12S, I15V, K20R, E35D, M36I, R41K, K45KR, R57K, L63T, E65D, I72T, T74S, L89MF
 842842_2004JQ083011None   L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, I72T, T74S, L89MF
Vicenti (2007)479867310REF376483None   T12N, I15V, E35D, M36I, R41K, R57K, I62V, L63T, E65D, T74S, V77VI, L89MF
Bartolo (2009)HDC24001AOHDC240EU068232None   L10I, I13V, G16E, E35D, M36I, P39Q, R41K, R57K, I62V, L63V, E65D, T74S, L89MF
Cardoso (2009)BRGO3148BRGO3148FJ594180None   K14KR, I15V, L19S, E35D, M36I, N37ND, R41K, R57K, Q61N, T74S, L89MF
Cuevas (2009)P1603P1603.1EU822712None   L19M, E35D, M36I, P39PS, R41K, Q61N, I62V, I72IT, T74S, L89MF
Koyalta (2009)28TCHAD-28FJ688182None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63A, T74S, L89MF
Vercauteren (2009)pt66wONy3cv3wrGQ400958None   L10I, I13IV, L19Q, E35D, M36I, N37NS, R41K, R57K, I62V, L63IT, E65D, T74S, L89MF
Djoko (2010)603CD4751FR666603None   G16E, K20R, E35D, M36I, P39S, R41K, K43R, Q61H, I62V, L63T, E65D, H69K, T74S, L89MF
Yebra (2010)29658106SP0296581FJ481657None   T12N, K14R, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
Aulicino (2011)494-B405494-B405HQ158251None   K14R, I15V, E35D, M36I, R41K, R57K, Q61D, I62V, T74S, I93LF
Florea (2011)100_2008100_2008JQ083013None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 102_2008102_2008JQ083014None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 1682_20071682_2007JQ083035None   L10V, K14KR, I15V, L19I, E35D, M36I, R41K, R57K, I62V, L63T, E65D, T74S, L89MF
 208_2008208_2008JQ083041None   L10V, T12N, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 4636_20084636_2008JQ083061None   T12K, I15V, E35D, M36I, N37D, R41K, K45R, R57K, L63T, E65D, T74S, L89MF
 4642_20074642_2007JQ083064None   I15V, G16GE, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 4643_20074643_2007JQ083065None   T12P, I15V, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 4650_20074650_2007JQ083070None   L10V, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MF
Sanabani (2011)BR2018BR2018JN692449None   T12E, K14E, I15V, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, E65R, T74S, L89MF
Frentz (2013)EHR-05814EHR-05814JX299635None   T12P, I15V, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 EHR-19555EHR-19555JX299868None   I15V, G16GE, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 EHR-36420EHR-36420JX300150None   T12P, I15V, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 EHR-57338EHR-57338JX300498None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 EHR-72070EHR-72070JX300760None   L10V, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MF
 EHR-72830EHR-72830JX300780None   T12K, I15V, E35D, M36I, N37D, R41K, K45R, R57K, L63T, E65D, T74S, L89MF
 EHR-83444EHR-83444JX300955None   L10V, T12K, K14R, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 EHR-98971EHR-98971JX301153None   L10V, I15V, E35D, M36I, R41K, R57K, I62V, L63V, E65D, T74S, L89MF
Temereanca (2013)SR12SR12JX966488None   L10V, T12P, K14R, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89M, I93MF
 SR18SR18JX966493None   L10V, I15V, L19I, E35D, M36L, R41K, R57K, L63T, E65D, H69R, T74S, L89MF
 SR2initSR2initJX966506None   L10V, T12K, I13V, I15V, G16E, L19I, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89M, Q92KF
 SR46SR46JX966522None   L10V, I15V, E35D, M36I, R41K, R57K, L63T, E65D, T74S, L89MF
 SR108SR108 None   T12N, I15V, K20R, E35D, M36I, R41K, R57K, I62IV, L63T, E65D, I72T, T74S, L89MF
 SR109SR109 None   L10V, E35D, M36I, R41K, R57K, I62V, L63V, T74S, L89MF
 SR107SR107 None   T12E, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63T, E65D, T74SF