<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation T74S
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 196
Isolates 197
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Brindeiro (2002)TVGG27TVGG27AY145828RTV, NFV30I54V, V82A, L90M L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, L89IF
Apetrei (2003)AC_Pat5RO.00.IS.05AY333471IDV M46I, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 AC_Pat24RO.00.IS.24AY333496IDV V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 AC_Pat26RO.00.IS.26AY333486IDV   L10V, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MF
  RO.01.IS.26AY333487IDV, RTV M46I, I54V, V82T, I84V L10V, I15V, E35D, M36I, R41K, K55R, R57K, L63T, E65D, I72V, T74S, L89MF
 AC_Pat37RO.00.IS.37AY333488IDV, RTV L90M L10V, T12S, I15V, L19I, K20T, E35D, M36I, R41K, R57K, I62V, L63T, E65D, T74S, L89MF
de Sa Filho (2003)BREPM046BREPM046AY182794IDV G48V, I54V, V82A L10I, I15V, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, I72IT, T74S, L89IMF
Dumans (2004)RG018RG018AY390205RTV, SQV, IDV, NFV, Unknown>252V82VA L10I, T12N, I15V, K20R, E35D, M36I, N37T, R41K, K45R, I54X, R57K, Q61N, I62V, L63C, A71AV, T74S, L89IM, I93LF
 RES077RES077AY390203SQV192L90MF53LL10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, T74S, L89MF
Gomez-Carrillo (2004)9732297322AY365545PINAI54V, V82AL24I, K43T, F53LL10I, T12K, I15V, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72V, T74SF
 103183103183AY365671PINAD30N, M46L, I54V, V82A, L90ML33F, N88DI13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63H, A71V, T74S, I93LF
 103840103840AY365687PINAG48V, I54V, V82A, L90M L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63T, E65D, I72T, T74SF
 109086109086AY365803PINAM46ML, I54V, V82A, L90M L10I, T12S, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, I62V, L63T, A71V, I72T, T74S, I93LF
 109089109089AY365804PINAI54V, V82A, L90MK43T, F53LL10I, L19I, K20R, E35D, M36I, R41K, Q61N, L63T, E65D, C67E, A71V, I72T, T74S, V77I, I93IMF
 113771113771AY365884PINAI47V, I54M, L90M L10I, I13IV, I15V, K20I, E35DN, M36I, R41K, R57K, Q61N, L63P, T74S, V82VI, I85VF
 115949115949AY365926PINAI54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63LP, T74S, L89MF
Montes (2004)MB_patBAR01_BAR714AJ577734RTV, SQV, NFV, APV, LPV273V82A L10I, K14Q, I15V, K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, L63C, E65D, T74S, L89MF
Non-B Workgroup (2005)PL23900101500 Unknown, LPV>58I54V, V82AL33F, N83DL10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, T74S, L89IF
Rodrigues (2005)BR0274502AY643151IDV202I54V, V82AL24IL10I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, L89MF
 BLF_Pat5BR03SP147AY643162Unknown, IDV>256I54V, V82A L10I, I13V, I15V, G17E, K20I, E35D, M36I, R41K, R57K, Q61N, L63R, E65D, T74S, L89IF
 BLF_Pat11BR03SP43AY643175IDV, Unknown, SQV, RTV, NFV>246I54V, V82A, L90M T12M, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, Q61H, I62V, H69R, T74S, L89I, C95CFF
 BLF_Pat14BR02SP108AY643134SQV, IDV194  I15V, E35ED, M36I, R41K, R57RK, Q61N, I62V, L63LP, I72IV, T74S, L89MF
 BLF_Pat20BR03SP220AY643168Unknown, NFV>173  L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63LP, E65D, T74S, L89MF
 BLF_Pat25BR02SP184AY643140NFV113L90M L10V, I15V, K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, I62V, L63A, T74S, L89MF
 BLF_Pat34BR02SP220AY643141NFV111L90M K20RT, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, L89I, I93LF
 BLF_Pat35BR03SP71AY643177IDV, NFV269I54V, L90M L10V, I13V, I15V, K20T, E35D, M36I, N37T, R41K, R57K, Q61N, A71T, T74S, L89IF
 BLF_Pat42BR02SP154AY643138RTV, Unknown, NFV>70L90M T12R, I15V, L19S, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, V77I, L89M, I93ILF
Baxter (2006)12-10691069-30528DQ876395PINAM46I, I54V, L76V, V82AK43TL10IV, T12I, I15V, K20R, E35D, M36I, R41K, K55R, D60DE, Q61N, I62IV, L63T, E65D, H69HR, I72T, T74S, L89MF
 48-10191019-30619DQ877325PINAG48V, I54V, V82AF53LL10I, I15V, K20R, E35D, M36I, R41K, Q61N, I62IV, L63S, I64L, I72T, T74S, L89M, I93LF
 48-11681168-30911DQ877356PINAI54V, V82A, I84VF53LL10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 48-11391139-30814DQ877399PINAM46L, G48V, I54T, V82AL24IL10I, K20R, E35D, M36I, N37DE, R41K, K43R, R57K, Q61N, L63C, T74S, L89MF
 48-10551055-30707DQ877421PINAM46I, I47V, I54V, V82F, L90MF53FLL10I, K20I, E35D, M36V, R41K, R57K, Q61N, I62IV, L63Q, I64IV, A71V, T74S, I93LF
 48-30433043-30305DQ877955PINAM46I, G48M, I54V, L76V, V82A, L90MK43T, F53LT4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, E65H, H69R, I72V, T74S, L89M, C95CSF
 48-60236023-30403DQ878622PINAG48M, I54V, V82AL24I, K43KT, F53LL10I, I15V, Q18E, K20R, E35D, M36I, N37NK, R41K, R57K, Q61N, E65D, T74S, L89MF
 48-61786178-30731DQ878750PINAM46MI, G48GV, I50V, I54V, V82TL33FL10V, I15V, K20R, E35D, M36I, P39PQ, R41K, R57K, Q61N, L63P, T74S, L89M, I93ILF
 48-93499349-30923DQ877289PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89IF
 48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
 48-91969196-30903DQ877572PINAM46I, I50V, I54V, V82AL33I, L76M, N83DL10V, T12E, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72T, T74S, L89IF
 48-93759375-30929DQ877684PINAL90M L10V, I13V, Q18L, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, V77I, L89MF
 48-91109110-30917DQ877697PINAI54A, V82A L10I, T12TN, I15V, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, I62V, L63C, A71V, T74S, L89LI, I93LF
Waleria-Aleixo (2008)08PR04019908PR040199FJ591229PINA  I15V, K20R, E35D, M36I, P39T, R41K, R57K, Q61D, I72R, T74S, L89MF
 RES222RES222FJ591939PINAL90M L10V, I15V, L19I, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, T74S, I93LF
 08PR05033108PR050331FJ591359PINAM46L, I54V, V82AL24I, K43T, F53LL10I, K14R, L19I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, I72AT, T74S, L89MF
 08PR04018508PR040185FJ591216PINAG48V, I54V, V82A, L90MK43TL10V, G17E, K20I, E35D, M36I, N37E, R41K, R57K, Q61D, I62V, A71V, I72R, T74S, L89I, I93LF
 08PR05038508PR050385FJ591410PINAL90MN83DL10I, I13V, I15V, K20V, E35N, M36I, N37Q, R41K, R57K, Q61D, I62V, A71T, I72T, T74S, L89IF
 08PR05033508PR050335FJ591363PINAM46ML, L90M L10V, I13V, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, L89TF
 08RJ06048808RJ060488FJ591681PINAM46I, L90M L10I, T12S, K20I, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, V77IF
 08RJ06060408RJ060604FJ591764PINAD30N, M46IN88DL10V, G16Q, E35D, M36V, P39T, R41K, K43R, R57K, D60E, Q61N, T74S, L89MF
 08PR06054908PR060549FJ591464PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63C, A71AT, T74S, Q92KF
 08RJ06057808RJ060578FJ591738PINAM46L, G48V, I54ST, V82ASK43KT, F53FLL10I, G16A, L19V, K20R, E35D, M36I, R41K, R57K, Q61N, E65D, T74S, L89MF
Dumans (2009)RES165_03RES165_03FJ405046SQV126I84V L10V, I15V, E35D, M36I, R41K, R57K, Q61D, H69Y, I72K, T74SF
 RENA636RENA636FJ405049NFV243D30NN88DI13V, I15V, K20T, E35D, M36I, R41K, Q61D, L63P, T74SF
 RENA162RENA162FJ405125SQV, NFV, IDV260  L10I, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, C67D, T74S, V77I, L89MF
 RENA463RENA463FJ405129NFV213L90M I13V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, T74S, L89M, I93ILF
 RENA254RENA254FJ405147IDV, NFV, Unknown>100V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, L89MF
 RES222_03RES222_03FJ405162NFV, Unknown>165L90M L10V, I15V, L19I, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, T74S, I93LF
 RENA446RENA446FJ405169RTV, NFV, Unknown, APV, SQV>205I54V, V82A, I84IV L10I, G17D, L19I, K20R, E35D, M36I, K55R, Q61D, L63T, E65D, I72T, T74S, L89MF
Sanabani (2009)56406BR564FJ771008PINAM46L, V82AK43TL10M, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, I85V, L89TF
Aulicino (2011)ARL684CJMARL684CJMFJ525816PINAI54V, V82AL24I, K43TL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, A71T, I72M, T74SF
 ARM144EJAARM144EJAFJ525825PINAM46L K14KR, I15V, K20I, E35D, M36I, R41K, R57K, Q61DN, L63P, E65D, T74S, L89MF
 ARN156RJEARN156RJEFJ525852PINAD30N, M46I, I54V, V82AL24I, L33F, N83D, N88DL10I, K20R, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63D, A71V, I72PT, T74SF
 ARN394FGLARN394FGLFJ525858PINAI54V, V82A, L90M L10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61D, I62V, L63V, A71V, I72V, T74SF
 4389-M378SL4389-M378SLHQ158152PINAI54V T12N, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62IV, L63T, I66F, H69R, T74SF
Jones (2012)128782128782JN669454PINAI54V, V82AL24I, K43TL10I, L19I, K20R, E35D, M36I, N37NH, R41K, R57K, Q61N, L63P, E65ED, A71V, I72T, T74S, V77VI, I93LF
 130542130542JN669493PINAI54V, V82A, I84VF53LT4TS, L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 146046146046JN669668PINAM46L, I54L, V82A, L90ML33FL10I, T12EQ, I15V, G16E, K20R, E34V, E35D, M36I, P39S, R41K, K55R, R57K, Q61N, I62V, L63T, A71V, I72T, T74S, L89M, I93LF
 147132147132JN669688PINAG48V L10V, I15V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, I72T, T74SF
 155191155191JN669834PINAI54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, L89MF
 155565155565JN669843PINAM46MI, I54V, V82ASL24I, G48GRL10I, I15V, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, L63LDHV, I72T, T74S, L89MF
 157578157578JN669892PINAD30N, I54VN88DK14R, G17E, K20R, E35D, M36V, N37E, R41K, K43R, R57K, Q61N, L63T, E65D, H69Y, I72T, T74S, L89MF
 158844158844JN669935PINAM46I, I47V, I54V, V82SL23I, K43T, F53LL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63A, A71V, I72V, T74S, L89M, I93LF
 159110159110JN669944PINAI54V, V82ML24I, K43TL10I, I15V, L19Q, K20R, E35D, M36V, R41K, R57K, Q61N, I62V, L63P, T74S, L89M, Q92KF
 160560160560JN669981PINAM46I, I54V, L76V, L90ML89VL10V, I13V, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KF
 160594160594JN669983PINA  G17E, E35D, M36I, N37K, R41K, R57K, Q61D, I62V, E65D, I72R, T74SF
 182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KF
 183721183721JN670658PINAL90M I13IV, I15V, G16GE, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, T74S, L89LIMF
 183778183778JN670660PINAL90M L10I, I15V, K20V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, T74S, I85V, Q92KF
 187322187322JN670731PINAM46L, V82A I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61D, L63T, E65D, I72T, T74SF
 190346190346JN670795PINAI54LV, V82AL24I, L33LFL10I, T12P, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61D, I62V, L63P, T74S, L89MF
 191048191048JN670808PINAM46I, I50V, I54V, V82AL33FL10V, K14KR, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72V, T74S, L89MF
 193629193629JN670906PINAL90M I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71AT, T74S, Q92QKF
 196676196676JN671032PINAD30NM46MV, N88DL5S, L10IV, I15A, G16E, Q18QR, K20I, E35N, M36I, P39S, R41K, Q61N, L63T, E65D, I72T, T74SF
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TF
 207640207640JN671442PINAM46L, G48AEKT, I54V, V82M, I84VL24I, L33I, K43T, F53FLL10I, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63IT, E65D, I72T, T74S, P79PS, L89MF
Alcantara (2013)BRGO4042BRGO4042JN114142PINA  Q18H, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89MF
Diaz (2015)RenG16848RenG16848KT747876PINAM46I, I54V, L76V, V82AL33F, K43T, N83DL10V, I13V, L19V, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, I62V, I72R, T74S, L89MF
 RenG16988RenG16988KT748016PINAM46I, I50L, V82CFLR, L90MF53LL10I, I13L, K20I, E34Q, E35D, M36I, N37T, R41K, K55KN, R57K, Q61N, L63C, I64L, A71V, I72T, T74S, L89M, I93LF
 RenG15534RenG15534KT746562PINAG48V, I54S, V82AK43TL10I, I15V, K20R, E35D, M36I, N37NS, R41RK, R57K, Q61N, I62V, A71V, I72T, T74S, L89I, I93LF
 RenG16059RenG16059KT747087PINAM46I, I54V, V82A, N88SL33F, K43KTL10I, I13V, I15V, K20T, E35D, M36I, R41N, R57K, Q61N, I62V, I64V, I72R, T74S, L89I, I93LF
 RenG16187RenG16187KT747215PINAM46I, I54V, V82AL24IL10I, T12E, K20R, E35D, M36I, N37D, R41K, K45R, K55R, R57K, Q61N, I62V, L63P, I64IL, H69HY, K70R, I72IV, T74S, L89MF
 RenG17165RenG17165KT748193PINAV32I, M46L, I47IV, I54LV, V82A, I84VL24I, L33FL10I, I13V, G17D, L19I, K20R, E35D, M36I, K43I, R57K, Q61N, L63V, E65D, I72T, T74S, V77IL, L89MF
 RenG16096RenG16096KT747124PINAM46L, I54V, V82AL24I, K43T, F53LL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, T74S, L89MF
 RenG16391RenG16391KT747419PINA  I15V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63S, E65D, T74S, L89MF
 RenG15931RenG15931KT746959PINAM46I, I47V, I54V, V82AK43T, F53LL10I, T12E, L19I, K20R, E35D, M36I, N37T, R41K, K55R, R57K, Q61N, I62V, L63T, I66F, I72V, T74S, V77VI, L89I, T91S, Q92K, F99FLF
 RenG16609RenG16609KT747637PINAM46I, I50V, I54V, V82AL24LI, L76ML10V, I15V, K20R, E35D, M36I, R41K, K45KR, K55R, R57K, Q61N, L63C, T74S, L89MF
 RenG16248RenG16248KT747276PINAM46L, I54V, L76V, V82A, L90ML23IL10I, I13V, I15V, K20I, E35N, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, I64L, A71V, I72V, T74S, I93LF
 RenG17432RenG17432KT748460PINAM46L, I54V, V82AL10F, L24I, F53FLI15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I64L, T74S, L89M, N98IF
 RenG16414RenG16414KT747442PINAL90ML23I, F53LL10V, K14R, I15V, K20T, E35D, M36I, N37ST, R41K, R57K, Q61D, I62IV, L63P, A71AV, I72IL, T74S, V77I, I93LF
 RenG16634RenG16634KT747662PINAI54AV, V82AG73GA, L89VL10I, I13AV, K14KR, K20I, A22AV, E35D, M36I, N37DE, R41RK, R57K, Q61N, L63LP, A71V, I72T, T74S, I93LF
 RenG16754RenG16754KT747782PINAV32I, M46I, I47V, I54M, V82VA, I84V, L90MV11I, L33F, K43TL10IV, I13V, E34K, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I85IV, L89M, Q92QRF
 RenG15544RenG15544KT746572PINAI54IV, V82VAQ58QEL10LV, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61DGNS, I62V, I72IT, T74S, L89MF
 RenG16257RenG16257KT747285PINAM46I, I54V, L76V, V82AL24IL10I, I13V, K20M, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63P, A71T, I72T, T74S, L89IF
 RenG15742RenG15742KT746770PINAG48V, I50V, I54V, V82A, L90ML33FL10IV, L19I, K20R, E34Q, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72V, T74S, L89M, I93LF
 RenG16292RenG16292KT747320PINA  K14R, I15V, E35D, M36I, R41K, R57K, Q61D, H69K, T74S, L89M, I93LF
 RenG17487RenG17487KT748515PINAI54V, V82A, L90ML33FL10I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63A, I64M, C67S, T74S, L89M, I93LF
 RenG16459RenG16459KT747487PINAM46I, I54V, V82F, L90ML33I, K43TL10V, I13V, K20T, E35D, M36L, N37D, R41K, F53Y, R57K, Q61N, I62V, L63P, T74S, V77I, L89I, I93LF
 RenG16671RenG16671KT747699PINA  K14R, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, I72IV, T74S, V82I, L89MF
 RenG15949RenG15949KT746977PINAG48A, I54V, L76V, V82A, L90MF53LL10I, I15V, G16GA, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63T, A71V, I72T, T74S, L89M, I93LF
 RenG16204RenG16204KT747232PINAM46I, I54V, L76V, V82A L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, T74S, L89MF
 RenG16180RenG16180KT747208PINA F53L, G73SL10V, I13V, I15V, K20T, E35D, M36I, N37T, R41K, K55HN, R57K, Q61N, L63P, A71T, T74S, V77I, Q92KF
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MF
 RenG15839RenG15839KT746867PINA  I15V, K20KM, E35D, M36I, R41K, R57K, Q61N, I62V, L63LP, T74S, L89MF
 RenG15851RenG15851KT746879PINAI54V, V82A L10V, I15V, K20R, E35D, M36I, N37ND, R41K, R57K, Q61N, I62V, L63S, E65D, I72V, T74S, I93LF
 RenG17275RenG17275KT748303PINAM46L, I54V, V82A, L90M L10I, I13V, K14R, I15V, L19V, K20T, E35N, M36I, N37D, R41K, Q61N, A71V, I72T, T74S, L89I, I93LF
 RenG15955RenG15955KT746983PINA  K20X, E35D, M36I, N37D, R41K, K55R, R57K, Q58K, Q61D, T74S, L89MF
 RenG17315RenG17315KT748343PINAM46I, I50L, V82A, N88NSL33F, F53LL10V, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, H69Y, A71V, I72T, T74S, L89TF
 RenG16638RenG16638KT747666PINAM46I, I50V, I54V, V82AK43TW6L, Q7A, L10V, D25Y, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG16948RenG16948KT747976PINAM46I, I50V, I54V, V82AK43TL10V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG14038RenG14038KT745066PINA  I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, V77I, I85IVF
 RenG14503RenG14503KT745531PINAM46I, I50V, I54V, V82A L10I, T12K, I13V, K14R, L19P, K20M, E35D, M36I, R41K, R57K, Q61N, I62IV, I64IV, T74S, L89IF
 RenG15034RenG15034KT746062PINAI54V, V82A, L90M L10I, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, I93LF
 RenG15080RenG15080KT746108PINAI54IV, V82A L10V, I15V, G17GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, H69Y, I72T, T74S, L89MF
 RenG13951RenG13951KT744979PINAI54V, V82A, L90M L10I, I15V, L19IV, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, I93LF
 RenG15167RenG15167KT746195PINAG48M, I54V, V82A, L90MK43T, F53LL10IV, V11L, T12P, I13V, K20I, E35D, M36I, N37K, R41K, R57K, Q61N, L63P, T74S, L89I, Q92KF
 RenG15110RenG15110KT746138PINAG48GA, I50IL, I54V, V82AT, L90ML33LI, F53FLL10I, T12K, I15V, L19P, K20V, E35D, M36I, N37NT, R41K, R57RK, Q61N, H69HR, K70KQ, A71AITV, T74S, V77VI, I85V, L89I, I93ILF
 RenG13750RenG13750KT744778PINAM46I, G48V, I50V, I54T, V82AL33FL10I, I15V, K20R, E34N, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, I85V, L89I, I93LF
 RenG14104RenG14104KT745132PINAG48M, V82S, I84VL24I, L33F, K43T, F53LL10V, I15IV, G16A, L19LV, K20R, E35D, M36I, N37K, R41K, R57K, D60E, Q61N, I62V, L63P, T74S, L89MF
 RenG14943RenG14943KT745971PINAG48V, I54V, V82A, L90ML33FL10IV, I13V, K14R, I15V, K20M, E35D, M36I, N37I, R41K, R57K, Q61N, T74S, L89I, Q92K, I93L, C95FF
 RenG14415RenG14415KT745443PINAM46ML, I54L, L90ML23LI, F53LL10IV, I15V, G16E, K20T, E35D, M36V, P39PS, R41K, R57K, Q61N, L63T, A71AV, I72T, T74S, I85V, L89IM, I93LF
 RenG15008RenG15008KT746036PINAM46I, I50V, I54V, V82AL24I, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65D, I72T, T74S, L89MF
 RenG15231RenG15231KT746259PINAM46L, I50L, V82AL33F, K43TL10V, I15V, G16E, K20R, E35N, M36I, N37NT, P39S, R41K, I62V, L63T, I64V, E65D, A71V, I72T, T74S, I93LF
 RenG14761RenG14761KT745789PINAD30N, G48V, I54V, V82AL24I, L33F, F53LL10I, I13V, K14R, I15V, K20M, E35D, M36I, N37D, R41K, R57K, Q61N, T74S, L89I, T91TS, Q92KF
 RenG15104RenG15104KT746132PINAG48V, I54V, V82A, L90ML33LFL10I, I13V, K14R, I15V, K20M, E35D, M36I, N37NIK, R41K, R57K, Q61N, T74S, L89I, Q92K, I93L, C95FF
 RenG15329RenG15329KT746357PINAL90LM I15V, G16E, K20T, E35DG, M36I, P39S, R41K, K45R, R57K, Q61D, L63C, I72V, T74S, L89MF
 RenG15101RenG15101KT746129PINAM46I, I54S, V82A, L90ML33I, K43TL10I, K14T, I15V, L19V, K20R, E35D, M36I, N37D, K55R, Q61N, T74S, I85V, L89IF
 RenG13963RenG13963KT744991PINAI54V, V82A L10V, I15IV, K20R, E35D, M36I, R41K, R57K, Q61N, T74S, L89MF
 RenG15255RenG15255KT746283PINAM46I, I47IV, I54IM, L90ML33F, F53FL, Q58EL10V, I15V, G16E, K20T, E35D, M36IV, P39S, K55R, R57K, Q61N, I62IV, L63T, I72T, T74S, L89MF
 RenG15076RenG15076KT746104PINAM46I, V82FF53L, N83DW6V, L10V, I13A, A22V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, H69R, T74S, L89I, I93LF
 RenG14682RenG14682KT745710PINAM46I, I54V, V82AN88DL10V, I13V, I15V, G16E, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63Q, I64V, T74SF
 RenG13779RenG13779KT744807PINA  E35D, M36I, P39S, R41K, R57K, Q61N, I62V, T74S, L89MF
 RenG13624RenG13624KT744652PINAM46L, V82VA L10I, T12K, K14I, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, E65D, T74S, L89MF
 RenG13569RenG13569KT744597PINAI50L, V82A, L90MK43T, G73SL10I, I13IV, I15V, K20R, E34EA, E35D, M36I, N37NT, R41K, K45KR, R57K, Q61N, I62V, L63P, A71I, T74SF
 RenG15068RenG15068KT746096PINAI50L, V82AL33F, F53FLT12I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, L63T, A71V, T74SF
 RenG13889RenG13889KT744917PINAG48V, I54T, V82AK43KTL10I, T12S, I13V, K20M, E35D, M36I, R41K, R57K, Q61N, T74S, L89I, N98K, F99FLF
 RenG15021RenG15021KT746049PINAM46L, I54LV, L76V, V82AL33FL10V, I13IV, G16E, L19V, K20R, E35D, M36I, N37DE, P39PQ, K55R, R57K, Q61N, L63T, E65D, I72V, T74S, L89MF
 RenG15203RenG15203KT746231PINAD30N, L90MN88DI13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, I64L, T74S, V77VI, L89M, I93LF
 RenG13959RenG13959KT744987PINAD30N, L90ML33LI, N88DL10Y, I15V, K20T, E35DN, M36I, N37D, R41K, R57K, Q61N, I62V, A71T, T74S, V77I, I85V, L89T, Q92QKRF
 RenG13911RenG13911KT744939PINAM46MI, I50IL, V82VA, L90MF53FLI13V, I15V, Q18V, L19LQ, K20T, E35D, M36I, N37T, R41K, K55R, R57K, Q61N, I62V, L63P, A71V, T74S, L89IT, Q92KF
 RenG14022RenG14022KT745050PINAL90M L10V, K14R, I15IV, G16E, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, I72IR, T74SF
 RenG14753RenG14753KT745781PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53LL10I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63AV, I64IL, T74S, L89MF
 RenG13465RenG13465KT744493PINAL90MF53LL10V, K20R, E35D, M36I, R41K, R57K, Q61N, L63H, I64V, T74S, L89MF
 RenG13393RenG13393KT744421PINAD30NL33F, F53L, N88DI15V, L19Q, K20T, E35D, M36I, N37NT, R41K, K45I, R57K, D60E, Q61E, I62V, L63P, I66F, A71V, T74S, V77I, V82I, L89T, Q92RF
 RenG13470RenG13470KT744498PINAM46I, I54V, L76V, V82A L10IV, I13IV, I15V, G16E, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, L63T, E65D, I72V, T74S, V77I, L89MF
 RenG13456RenG13456KT744484PINAI50L, V82AL33F, F53LL10I, I13V, I15V, K20V, E35N, M36I, R41K, K43S, K55R, R57K, Q61N, L63P, H69HY, A71LV, T74SF
 RenG13144RenG13144KT744172PINAM46L, I50L, V82AL33FK20R, E35D, M36I, N37I, R41K, K55KR, R57K, Q61D, T74S, L89M, I93ISF
 RenG12314RenG12314KT743342PINAD30N, I54LL33F, Q58QE, N88DR8P, L10V, I13V, I15V, K20T, T31A, E35D, M36I, K43R, R57K, Q61N, L63C, T74S, L89IMF
 RenG12397RenG12397KT743425PINA  W6GR, I15V, E35D, M36I, R41K, R57K, Q61N, L63T, I72T, T74S, V77I, L89MF
 RenG13137RenG13137KT744165PINAM46I, I54A, V82A, L90ML33IL10I, T12P, I15V, L19P, K20V, E35N, M36I, R41K, R57K, Q61N, I62V, K70E, A71V, T74S, G86GA, L89I, T91S, I93LF
 RenG12629RenG12629KT743657PINA  T12KN, I15V, L19I, K20R, E35D, M36I, P39Q, R41K, R57K, Q61D, L63T, I72T, T74S, L89MF
 RenG12728RenG12728KT743756PINAM46L, I54V, V82AK43TL10V, T12I, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, I62V, L63P, T74S, L89IF
 RenG12485RenG12485KT743513PINAM46L, I54V, V82A I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89IF
 RenG12665RenG12665KT743693PINAG48QR, I84V, L90ML33F, N83DL10V, K20R, E35D, M36L, R41K, R57K, Q61D, I62V, L63P, T74S, L89IF
 RenG13329RenG13329KT744357PINAN88SF53LG17E, L19I, K20T, E35D, M36I, N37T, R41K, R57K, Q61N, I62V, E65D, A71V, I72V, T74S, V77I, L89M, Q92KF
 RenG13251RenG13251KT744279PINAM46I, L76V, V82A I15V, K20T, E34K, E35D, M36V, P39S, R41K, R57K, D60E, Q61N, I62V, L63P, T74S, L89MF
 RenG13242RenG13242KT744270PINAM46ML, I54V, V82A, L90MF53FLL10V, I15V, G16A, L19LV, K20R, E35D, M36I, N37NDIV, R41K, K55R, R57K, Q61N, L63LP, T74S, I85IV, L89I, Q92QKF
 RenG13505RenG13505KT744533PINAL90M L10V, I13V, K20R, E35D, M36L, R41K, R57K, Q61N, I62V, L63P, T74S, L89I, I93LF
 RenG12789RenG12789KT743817PINAM46L, I50L, V82A L10V, I13IV, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I64IV, K70R, A71AV, I72IV, T74S, V75VI, L89MF
 RenG11848RenG11848KT742876PINA Q58EI15V, E35D, M36I, P39Q, R41K, R57K, D60E, Q61N, L63T, I72V, T74S, L89MF
 RenG12768RenG12768KT743796PINA  K20I, E35D, M36I, R41K, K43R, R57K, Q61N, T74S, L89I, I93LF
 RenG12636RenG12636KT743664PINAD30N, V32VI, M46I, I47V, I54LVF53FL, L76LM, N88DL10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92RF
 RenG12471RenG12471KT743499PINA  L10V, T12P, K14KR, R41K, R57K, Q61N, L63P, T74S, V77I, L89M, I93LF
 RenG12419RenG12419KT743447PINAI50L, V82A, L90ML33IL10V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I64IV, A71LV, T74S, I93LF
 RenG12278RenG12278KT743306PINAD30NF53L, N88DL10V, I13V, I15V, K20T, E35D, M36I, Q61N, A71V, T74S, V77I, L89T, Q92RF
 RenG12087RenG12087KT743115PINAM46L, I54V, L76V, V82MQ58EL10I, I13V, I15V, K20T, E35DN, M36I, R41K, R57K, Q61N, I62V, E65D, T74S, L89MF
 RenG12683RenG12683KT743711PINAI54V, V82TL24IL10I, T12TK, I13V, K20I, E35D, M36I, R41K, R57K, Q61N, L63A, T74S, L89IF
 RenG12097RenG12097KT743125PINA  L10V, T12I, I15V, G16E, E35D, M36I, R41K, K43KR, R57K, D60E, Q61N, L63T, I72T, T74S, L89MF
 RenG12193RenG12193KT743221PINAM46I, I54V, L76V, V82A, L90M L10I, I15V, L19I, K20R, E34N, E35D, M36I, R41K, K55R, R57K, Q61D, I62V, L63P, I72V, T74SF
 RenG12955RenG12955KT743983PINA  L10V, I15V, E35D, M36I, R41K, R57K, D60N, Q61D, L63C, T74S, L89M, I93LF
 RenG13129RenG13129KT744157PINAM46L, I54V, V82A, L90MN88DL10V, I13K, I15G, K20I, E35N, M36I, L38F, R41K, R57K, Q61H, L63I, A71T, T74S, L89I, Q92KF
 RenG12221RenG12221KT743249PINAM46IF53FLL10V, T12S, I13V, K14R, I15V, L19V, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, A71AV, T74S, L89T, I93LF
 RenG11377RenG11377KT742405PINAL90M L10V, T12I, Q18E, E35D, M36IV, R41K, R57K, Q61N, I62V, L63T, I64V, I72T, T74S, I93ILF
 RenG11775RenG11775KT742803PINAM46L, I54V, L76LV, V82A, L90M L10V, K14R, I15V, G16E, K20MT, E35N, M36I, N37D, R41K, K55KR, R57K, Q61N, I62IV, L63HP, T74S, V77VI, I85V, L89I, I93LF
 RenG11433RenG11433KT742461PINAI54A, V82A, L90M L10I, I13V, K14R, I15IV, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, Q61N, I62V, L63P, A71V, I72T, T74S, L89I, Q92KF
 RenG11135RenG11135KT742163PINAM46MI, I54V, L90M I13IV, K14KR, I15V, K20T, E35D, M36I, P39V, R41K, R57K, Q61N, I62V, L63A, I72V, T74S, L89I, Q92KF
 RenG11560RenG11560KT742588PINAI54V, V82A, L90MF53LL10I, I15V, K20R, L24F, E34ADNT, E35D, M36I, N37D, R41K, K55R, R57K, D60E, Q61N, L63P, A71I, I72V, T74S, I93LF
 RenG11539RenG11539KT742567PINAV32I, M46I, I47V, I54L, V82AL10FI, L33LF, N83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, Q61N, I64V, A71V, T74S, T91S, I93LF
 RenG10010RenG10010KT741038PINAM46I, I54VL24I, K43T, F53FL, V82NL10I, I13IV, K14KR, I15V, G16A, K20R, E35D, M36I, N37DE, R41K, K55R, R57RK, Q61N, L63PST, I64IL, C67E, H69HR, T74S, L89MF
 RenG11226RenG11226KT742254PINAV32I, I54A, V82AL24I, K43TL10I, K20R, L33*, E34K, E35D, M36I, R41K, R57K, Q61N, L63V, I64V, T74SF
 RenG11176RenG11176KT742204PINAM46I, I47V, I54V, V82AF53LL10I, T12S, I13V, K20I, M36D, N37I_D, R41K, R57K, Q61N, T74S, L89MF
 RenG11316RenG11316KT742344PINAI54V, V82A L10I, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I72T, T74S, L89M, I93LF
 RenG11532RenG11532KT742560PINAG48A, I54A, V82A W6W*, L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36V, N37K, R41K, R57K, Q61N, L63T, I72T, T74S, L89MF
 RenG10275RenG10275KT741303PINAI50L T12M, I13IM, I15V, K20V, E35N, M36I, N37D, R41K, F53I, R57K, Q61N, L63LP, I64V, A71V, T74S, I85IV, L89M, Q92RF
 RenG10824RenG10824KT741852PINAV32I, M46I, I47V, I54M, V82A, L90MV11I, L33F, K43T, F53FLL10V, I13V, E34R, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, L89M, Q92RF
 RenG10083RenG10083KT741111PINAM46I, I50IL, V82AV32VA, L33F, N83NDL10V, T12E, I13V, I15IV, Q18QH, L19I, K20R, E35D, M36I, N37E, R41K, K55KN, R57K, Q61N, I62V, L63P, K70R, A71AV, T74S, V75IF
 RenG11711RenG11711KT742739PINAM46L, I54V, V82AL24I, L33F, K43T, G48E, F53LL10I, I15V, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, T74S, L89I, Q92KF
 RenG10060RenG10060KT741088PINAM46I, I50IL, I54V, V82AL24I, L33LF, K43TL10I, I15V, K20R, E35D, M36IV, R41K, R57K, Q61N, I62V, L63S, H69C, I72T, T74S, L89M, Q92QKF
 RenG11273RenG11273KT742301PINA  W6V, T12I, I15V, G16E, E35D, M36I, N37D, P39S, R41K, R57K, Q61N, I72V, T74S, L89MF