<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation T74A
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 18
Isolates 18
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Dumans (2004)RES093RES093AY390211IDV, RTV, Unknown>87I54V, V82AT, L90MF53LL10IV, K14R, I15V, G17D, L19I, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, A71V, I72T, T74A, L89M, I93LF
 F131F131AY390084RTV, IDV, Unknown>9M46I, I54V, V82A, L90M Q7H, L10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K55E, R57K, D60E, Q61D, K70R, I72V, T74AF
Gomez-Carrillo (2004)105358105358AY365725PINAI54V, V82AF53LL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, T74A, I93LF
 122345122345AY366009PINAG48V, V82AF53LL10V, I15V, G16E, K20M, E35D, M36I, P39Q, R41K, K55R, R57K, Q61N, L63T, T74AF
 123281123281AY366020PINAI54L I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, I64V, I72R, T74A, V75I, I93LF
Rodrigues (2005)BLF_Pat22BR03SP87AY643178RTV, NFV, APV217M46L, I54V, V82AL24I, Q58EL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, T74A, L89MF
Baxter (2006)48-61566156-30701DQ878732PINAI54V, V82A L10I, T12K, I15V, G16A, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, I93LF
 48-92729272-30922DQ877288PINAM46L, I54V, V82A, L90LM L10I, I15V, L19Q, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, T74A, L89I, I93LF
Dumans (2009)RES303_03RES303_03FJ405041RTV, Unknown>157I54V, V82A L10I, K14R, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, T74A, L89MF
Jones (2012)146813146813JN669682PINAI54V, V82A, L90M L10I, T12TP, I15V, Q18K, K20M, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74A, V75VA, L89MF
 157272157272JN669879PINAD30NN88DI15V, K20T, E35DN, M36I, R41K, R57K, Q61D, T74AF
 188046188046JN670747PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, T74A, I93LF
 192661192661JN670862PINAI54V, V82AQ58EL10V, I15V, K20R, D25DG, E35D, M36I, R41K, R57K, Q61N, T74A, L89MF
 193358193358JN670894PINAL90M L10LI, T12N, I15V, K20M, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, I72T, T74AF
 195689195689JN670995PINA  I15V, G16E, Q18K, K20M, E35D, M36I, R41K, R57K, Q61S, T74A, L89MF
 205791205791JN671372PINAI54V, I84V, L90M L10I, I13IV, I15V, Q18K, K20M, E35D, M36I, R41K, Q61N, I62V, L63P, I66IV, T74A, L89IF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF
 207575207575JN671439PINAM46MI, I50VL33FK14S, I15V, K20KT, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, T74A, I85IV, L89MF