<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation T74A
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 41
Isolates 41
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Dumans (2004)RES093RES093AY390211IDV, RTV, Unknown>87I54V, V82AT, L90MF53LL10IV, K14R, I15V, G17D, L19I, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, A71V, I72T, T74A, L89M, I93LF
 F131F131AY390084RTV, IDV, Unknown>9M46I, I54V, V82A, L90M Q7H, L10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K55E, R57K, D60E, Q61D, K70R, I72V, T74AF
Gomez-Carrillo (2004)105358105358AY365725PINAI54V, V82AF53LL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, T74A, I93LF
 122345122345AY366009PINAG48V, V82AF53LL10V, I15V, G16E, K20M, E35D, M36I, P39Q, R41K, K55R, R57K, Q61N, L63T, T74AF
 123281123281AY366020PINAI54L I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, I64V, I72R, T74A, V75I, I93LF
Rodrigues (2005)BLF_Pat22BR03SP87AY643178RTV, NFV, APV217M46L, I54V, V82AL24I, Q58EL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, T74A, L89MF
Baxter (2006)48-61566156-30701DQ878732PINAI54V, V82A L10I, T12K, I15V, G16A, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, I93LF
 48-92729272-30922DQ877288PINAM46L, I54V, V82A, L90LM L10I, I15V, L19Q, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, T74A, L89I, I93LF
Dumans (2009)RES303_03RES303_03FJ405041RTV, Unknown>157I54V, V82A L10I, K14R, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, T74A, L89MF
Jones (2012)146813146813JN669682PINAI54V, V82A, L90M L10I, T12TP, I15V, Q18K, K20M, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74A, V75VA, L89MF
 157272157272JN669879PINAD30NN88DI15V, K20T, E35DN, M36I, R41K, R57K, Q61D, T74AF
 188046188046JN670747PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, T74A, I93LF
 192661192661JN670862PINAI54V, V82AQ58EL10V, I15V, K20R, D25DG, E35D, M36I, R41K, R57K, Q61N, T74A, L89MF
 193358193358JN670894PINAL90M L10LI, T12N, I15V, K20M, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, I72T, T74AF
 195689195689JN670995PINA  I15V, G16E, Q18K, K20M, E35D, M36I, R41K, R57K, Q61S, T74A, L89MF
 205791205791JN671372PINAI54V, I84V, L90M L10I, I13IV, I15V, Q18K, K20M, E35D, M36I, R41K, Q61N, I62V, L63P, I66IV, T74A, L89IF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF
 207575207575JN671439PINAM46MI, I50VL33FK14S, I15V, K20KT, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, T74A, I85IV, L89MF
Diaz (2015)RenG16827RenG16827KT747855PINAI54V, V82F, I84VF53LL10V, I15V, G16E, K20T, E35D, M36I, P39Q, R41K, K45V, R57K, D60E, Q61D, I72R, T74A, V77I, L89MF
 RenG16517RenG16517KT747545PINAM46IV32A, L33FL10V, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65D, I72T, T74A, L89MF
 RenG16832RenG16832KT747860PINAG48ML23I, F53LL10I, T12R, I15V, G16E, L19IV, K20T, E35D, M36I, P39Q, R41K, Q61N, I62IV, L63T, E65D, I72T, T74A, V75I, I93LF
 RenG15805RenG15805KT746833PINAI50L, N88S L10M, K14R, I15V, G16E, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, L89MF
 RenG16619RenG16619KT747647PINAM46I, I50V, I54V, N88S L10I, I15V, K20T, E35D, M36I, R41K, R57K, Q61D, I62V, L63V, I64V, T74A, L89M, I93LF
 RenG15740RenG15740KT746768PINAM46I, V82AV32A, L33F, F53LL10I, I13V, G16E, K20R, E35D, M36L, R41K, Q61N, L63T, I66F, I72T, T74A, L89MF
 RenG15411RenG15411KT746439PINA F53FLL10V, I15V, E35D, M36L, L38W, R41K, K45KR, R57K, Q61D, I62V, L63LP, I64M, T74A, L89MF
 RenG13983RenG13983KT745011PINA  L10I, I15V, K20T, E34A, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, E65D, T74A, L89T, I93LF
 RenG14989RenG14989KT746017PINAI50L, V82AL33F, F53LI13V, I15V, K20R, E35D, M36I, N37IS, R41K, R57K, Q61N, L63T, I64L, K70Q, I72T, T74A, L89MF
 RenG14293RenG14293KT745321PINAM46L, I54V, L76V, V82AL33FL10V, I13V, G16E, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63V, E65D, I72T, T74A, L89MF
 RenG13960RenG13960KT744988PINAG48A, I54V, V82AF53LL5LP, W6L, L10I, I13N, I15L, G16E, E35D, M36I, P39S, R41K, K55R, R57K, D60E, Q61D, I62V, H69Y, A71AV, I72R, T74A, L89I, I93ILF
 RenG13781RenG13781KT744809PINAM46I, I50V, I54V, L76V L10I, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63V, I64IV, A71V, T74A, V82I, L89M, I93LF
 RenG15019RenG15019KT746047PINAI50L, V82L, N88SL33FI13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, T74A, L89MF
 RenG12409RenG12409KT743437PINAM46L, I54V, I84VN83DL10I, T12I, I13V, A22V, E35D, M36I, R41K, K55R, R57K, Q61D, I62V, L63P, K70R, T74A, L89I, T91SF
 RenG13387RenG13387KT744415PINAI50LL33F, F53LK20R, E34N, E35D, M36I, P39Q, R41K, R57K, Q61N, E65D, I72T, T74A, L89IMF
 RenG12250RenG12250KT743278PINAI54V, V82AV11VI, L33LI, F53LL5LF, W6C, Q7K, T12I, I13V, G16E, K20I, E35D, M36I, R41K, R57K, Q61D, I62V, A71V, I72R, T74A, L89I, T96XF
 RenG12448RenG12448KT743476PINAV32VI, M46I, I47IV, I50L, I54V, V82SF53FL, L76LML10I, K14R, I15V, G16E, K20R, E34EA, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, A71V, I72T, T74A, L89M, I93LF
 RenG12149RenG12149KT743177PINAM46I, I50L, I54V, V82A, L90M L10V, I15V, G16E, K20I, E34A, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, A71V, I72R, T74A, I93LF
 RenG10066RenG10066KT741094PINAM46L, I54V, V82AL24I, K43TL10V, K14R, I15V, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, Q61N, I62V, L63V, E65D, T74A, L89MF
 RenG11454RenG11454KT742482PINAM46L, G48A, I54V, V82AL24I, F53LL10I, I15V, L19LV, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, T74A, L89MF
 RenG11190RenG11190KT742218PINAM46I, I50V, I54V, V82F L10V, I13V, I15V, K20T, E35ED, M36I, N37NK, R41K, R57K, Q61HN, L63DGNS, E65D, I72T, T74A, V77I, L89LMF
 RenG10888RenG10888KT741916PINAM46I, I50V, I54V, V82AL24I, L33FL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63P, T74A, L89MF
 RenG10048RenG10048KT741076PINAI54V, V82AL33I, K43T, F53L, N83DI13V, G17A, Q18H, K20R, A22V, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, A71T, I72T, T74A, L89I, T91S, Q92HF