<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63T
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 184
Isolates 196
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Masciotra (2000)SM47SM47AF221051PINA  L10I, E35D, M36I, R57K, Q61N, L63T, I64L, T96SF
Gibb (2002)DMG6464_w26 NFV26D30N I15V, G16E, K20R, E35D, M36I, N37NT, R41K, R57K, L63T, E65D, I72TF
 DMG8686_w25 NFV8  L10V, I13V, I15V, G16E, K20KR, E35D, M36I, R41K, R57K, L63T, E65D, I72IATV, L89MF
Apetrei (2003)AC_Pat1RO.00.IS.01AY333462IDV, UnknownNAM46I, I54V, V82AL24I, K43TL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
  RO.01.IS.01AY333463IDV, Unknown, SQV, NFVNAM46I, I54V, V82A, I84VL24I, K43T, G48W, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat2RO.00.IS.02AY333504IDV   I15V, G16E, Q18E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72TF
 AC_Pat4RO.00.IS.04AY333484IDV, SQV, NFV   L10V, T12S, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat5RO.00.IS.05AY333471IDV M46I, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 AC_Pat6RO.00.IS.06AY333525IDV, RTV, NFV   I15V, L19I, E35D, M36I, R41K, R57K, I62V, L63T, E65D, V82I, L89M, I93LF
  RO.01.IS.06AY333526IDV, RTV, NFV, UnknownNA  L10V, I15V, L19I, K20T, E35D, M36I, R41K, R57K, I62V, L63T, E65D, V82I, L89M, I93L, F99YF
 AC_Pat7RO.00.IS.07AY333458IDV, SQV, NFV, UnknownNAM46L, I54V, V82A L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
  RO.01.IS.07AY333459IDV, SQV, NFV, UnknownNAM46L, I54V, V82A L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat8RO.00.IS.08AY333522IDV, Unknown, SQV, NFVNA  T12S, I15V, Q18E, L19T, K20R, E35D, M36I, R41K, R57K, L63T, E65DF
  RO.01.IS.08AY333523IDV, Unknown, SQV, NFV, RTVNA  T12S, I15V, Q18E, L19T, K20R, E35D, M36I, R41K, R57K, L63T, E65DF
 AC_Pat20RO.00.IS.20AY333497IDV   I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
  RO.01.IS.20AY333498IDV, RTV   I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat21RO.00.IS.21AY333455IDV   I15V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, L89MF
  RO.01.IS.21AY333456IDV   T12I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, L89MF
 AC_Pat22RO.00.IS.22AY333460IDV, RTV, NFV I54V, V82A L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MF
 AC_Pat23RO.00.IS.23AY333499IDV V82A I15V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, I72T, L89MF
  RO.01.IS.23AY333500IDV, SQV, NFV V82A L10V, I15V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, I72T, L89MF
 AC_Pat24RO.00.IS.24AY333496IDV V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MF
 AC_Pat25RO.00.IS.25AY333502IDV   L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72TF
  RO.01.IS.25AY333503IDV G48V, V82A L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72TF
 AC_Pat26RO.00.IS.26AY333486IDV   L10V, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MF
  RO.01.IS.26AY333487IDV, RTV M46I, I54V, V82T, I84V L10V, I15V, E35D, M36I, R41K, K55R, R57K, L63T, E65D, I72V, T74S, L89MF
 AC_Pat27RO.00.IS.27AY333516IDV   T12S, I15V, L19V, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63T, E65D, L89MF
  RO.01.IS.27AY333517IDV   T12S, I15V, L19V, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63T, E65D, L89MF
 AC_Pat28RO.00.IS.28AY333452IDV   I15V, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat29RO.00.IS.29AY333511IDV   T12S, I15V, G16E, K20R, E35D, M36I, R57K, L63T, E65D, I72T, L89MF
 AC_Pat30RO.00.IS.30AY333513IDV, RTV, SQV, NFV   T12S, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89M, Q92KF
 AC_Pat31RO.00.IS.31AY333518IDV   T12S, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, L89MF
  RO.01.IS.31AY333519IDV, SQV, NFV   T12S, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, L89MF
 AC_Pat33RO.00.IS.33AY333477IDV   L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89MF
  RO.01.IS.33AY333478IDV, NFV   L10V, I13V, I15V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, I72V, L89MF
 AC_Pat34RO.00.IS.34AY333521IDV   L10V, T12S, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MF
 AC_Pat35RO.00.IS.35AY333491IDV   L10V, I15V, G16E, E35D, M36I, R41K, R57K, I62V, L63T, E65D, L89MF
 AC_Pat36RO.00.IS.36AY333461IDV, RTV, SQV, NFV M46L, I54V, V82A L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, K70E, I72T, L89MF
 AC_Pat37RO.00.IS.37AY333488IDV, RTV L90M L10V, T12S, I15V, L19I, K20T, E35D, M36I, R41K, R57K, I62V, L63T, E65D, T74S, L89MF
 AC_Pat39RO.00.IS.39AY333501IDV   I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MF
 AC_Pat40RO.00.IS.40AY333465IDV M46I, I54V, V82A L10V, I15V, G17E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat41RO.00.IS.41AY333507IDV   T12I, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat42RO.00.IS.42AY333520IDV25  L10V, T12S, I15V, L19V, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89M, I93LF
 AC_Pat43RO.00.IS.43AY333509IDV   T12N, I15V, G16E, K20R, E35D, M36I, R57K, I62V, L63T, E65D, I72T, L89MF
 AC_Pat44RO.00.IS.44AY333453IDV, RTV, SQV, NFV   I15V, K20R, L23V, E35D, M36I, R41K, R57K, L63T, E65D, I72T, C95N, L97IF
 AC_Pat45RO.00.IS.45AY333473IDV I54V, V82A L10V, I15V, K20R, L23V, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat46RO.00.IS.46AY333454IDV, Unknown, SQV, NFVNA  I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat47RO.00.IS.47AY333457IDV   T12S, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V82I, L89MF
Monno (2003)ML_Pat12ML_Pat12 PINA  I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72IT, L89MF
Dumans (2004)RES093RES093AY390211IDV, RTV, Unknown>87I54V, V82AT, L90MF53LL10IV, K14R, I15V, G17D, L19I, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, A71V, I72T, T74A, L89M, I93LF
Gomez-Carrillo (2004)103840103840AY365687PINAG48V, I54V, V82A, L90M L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63T, E65D, I72T, T74SF
 109089109089AY365804PINAI54V, V82A, L90MK43T, F53LL10I, L19I, K20R, E35D, M36I, R41K, Q61N, L63T, E65D, C67E, A71V, I72T, T74S, V77I, I93IMF
Non-B Workgroup (2005)PL4965792049 LPV8  I15V, G17E, K20R, E35D, M36I, R57K, Q61H, L63T, I72T, L89MF
Rodrigues (2005)BR0181201AY643188RTV, NFV52M46MI, V82VA L10I, I15V, Q18L, K20KR, E35D, M36I, R41K, R57K, D60E, Q61N, L63T, C67X, H69Q, I72T, L89MF
 BLF_Pat29BR03SP247AY643171Unknown, NFV, SQV, RTV>88I54V, V82AN83DL10I, I15V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, I72T, L89M, I93LF
Baxter (2006)12-10691069-30528DQ876395PINAM46I, I54V, L76V, V82AK43TL10IV, T12I, I15V, K20R, E35D, M36I, R41K, K55R, D60DE, Q61N, I62IV, L63T, E65D, H69HR, I72T, T74S, L89MF
 48-12711271-30923DQ877792PINAG48V, I54V, V82SL24I, L33F, Q58EL10I, I15V, G16E, K20R, E34Q, E35D, M36I, P39PT, R41K, R57K, I62V, L63T, E65D, I72T, L89MF
 48-20132013-30324DQ877845PINAM46L, I54V, V82AL24I, Q58QEL10V, I15V, K20R, E35D, M36I, I62V, L63T, I72T, T74A, L89MF
 48-30433043-30305DQ877955PINAM46I, G48M, I54V, L76V, V82A, L90MK43T, F53LT4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, E65H, H69R, I72V, T74S, L89M, C95CSF
 48-92509250-30908DQ877602PINAM46L, I54V, V82AV11VI, L24I, L33F, T74PL10I, I13V, G17E, L19I, K20R, E35D, M36I, R41K, R57K, Q61DN, I62V, L63T, E65D, I72T, L89MF
 48-90929092-30827DQ877655PINAM46I, I54V, V82A, L90MK43T, F53FLL10I, K20R, E35D, M36I, R41K, K55KR, R57K, Q61D, I62V, L63T, E65ED, I72T, T74TS, L89MF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
Waleria-Aleixo (2008)08PR06054508PR060545FJ591461PINA  G16E, E35D, M36I, P39PS, R41K, Q61N, I62V, L63T, I64L, V77I, L89MF
 08PR05033108PR050331FJ591359PINAM46L, I54V, V82AL24I, K43T, F53LL10I, K14R, L19I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, I72AT, T74S, L89MF
 08PR05036008PR050360FJ591386PINAL90M I15V, G17D, K20R, E35N, M36I, K43Q, R57K, Q61DN, L63T, L89MF
 08PR06065408PR060654FJ591509PINAN88S, L90M L10I, I13V, K14Q, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, L89MF
 08RJ06050108RJ060501FJ591693PINAL90MT74PL10V, I15V, G16Q, K20T, E35N, M36I, P39T, R41K, R57K, D60E, Q61D, L63T, I64V, I72V, L89MF
 08RJ06061808RJ060618FJ591778PINAM46I, I50V, L76V, V82AL24I, L33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, K55KR, R57K, Q61N, L63T, C67E, L89MF
 08RJ06066908RJ060669FJ591784PINAM46L, I54V, V82A, L90MT74PL10V, G17E, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63T, E65D, I72T, L89MF
 RES261RES261FJ591964PINA  L10I, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, C67S, V77IF
Dumans (2009)RENA162RENA162FJ405125SQV, NFV, IDV260  L10I, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, C67D, T74S, V77I, L89MF
 RENA569RENA569FJ405166Unknown, NFV, RTV, IDV, APV>136  L10V, T12M, I15A, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, L89MF
 RENA446RENA446FJ405169RTV, NFV, Unknown, APV, SQV>205I54V, V82A, I84IV L10I, G17D, L19I, K20R, E35D, M36I, K55R, Q61D, L63T, E65D, I72T, T74S, L89MF
Aulicino (2011)4389-M378SL4389-M378SLHQ158152PINAI54V T12N, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62IV, L63T, I66F, H69R, T74SF
Aulicino (2012)AR02ARG2233ARG2233EU581826PINA  I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63TF
Jones (2012)130439130439JN669490PINAM46I, I54V, V82A L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61E, L63T, E65D, I72T, I93LF
 148547148547JN669716PINA  I15V, G16E, E35ED, M36I, P39PS, R41K, K43R, R57K, Q61N, L63T, E65D, I72ITF
 156113156113JN669851PINA  T12K, I15IV, L19I, R41K, R57RK, Q61N, L63T, E65D, I72T, V77I, P79PSF
 156594156594JN669867PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K14R, Q18E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, E65D, A71V, L89M, I93LF
 157578157578JN669892PINAD30N, I54VN88DK14R, G17E, K20R, E35D, M36V, N37E, R41K, K43R, R57K, Q61N, L63T, E65D, H69Y, I72T, T74S, L89MF
 169379169379JN670198PINAI50L, V82AQ58QEI15V, K20R, E34K, M36I, R41K, K43R, Q61D, L63T, E65D, I72T, T74SF
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MF
 187322187322JN670731PINAM46L, V82A I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61D, L63T, E65D, I72T, T74SF
 189227189227JN670768PINAM46I, I47V, I54V, L76V, V82A L10V, T12TK, I15V, G16E, L19I, K20R, E35D, M36I, R41K, K45R, K55KR, R57K, Q61N, L63T, A71V, I72T, I93LF
 192746192746JN670864PINAV82A K20R, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, E65D, I72T, Q92KF
 194537194537JN670939PINA  I15V, G17E, K20R, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, K70KR, I72VF
 197471197471JN671074PINAM46I, I84VL10F, F53L, T74PI13V, G16E, L19I, K20T, E35D, M36I, P39Q, K55R, R57K, D60E, Q61N, L63T, I64IV, E65D, L89MF
 198926198926JN671140PINA  L10I, T12I, I15V, G16E, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, I93LF
 204494204494JN671343PINAM46L, I54V, V82AL24IL10V, T12N, I15V, K20R, E35D, M36I, R41K, Q61N, L63T, E65D, I72TF
Kouri (2012)CU2073-09CU2073-09JQ585339PINAM46L, I54V, V82AF53LL10I, I13V, G16E, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, Q61H, L63T, E65D, I72T, T74A, L89MF
 CU772-10CU772-10JQ585416PINAM46L, I54AV, V82AL33F, T74AP, N83NDL10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, L89MF
Diaz (2015)RenG17481RenG17481KT748509PINA  E35D, M36I, R41K, R57K, Q61N, L63T, E65D, L89MF
 RenG16649RenG16649KT747677PINAM46L, I54V, V82A, L90MK43T, T74PL10IV, T12K, I13V, K14KR, I15V, K20I, E35N, M36I, R41K, Q61N, L63T, E65D, I72T, L89MF
 RenG17381RenG17381KT748409PINA  L10V, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, I72T, L89LMF
 RenG15931RenG15931KT746959PINAM46I, I47V, I54V, V82AK43T, F53LL10I, T12E, L19I, K20R, E35D, M36I, N37T, R41K, K55R, R57K, Q61N, I62V, L63T, I66F, I72V, T74S, V77VI, L89I, T91S, Q92K, F99FLF
 RenG17156RenG17156KT748184PINA  I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61S, L63TF
 RenG16518RenG16518KT747546PINAM46I, I47V, I54V, V82A, L90MV11I, K43T, F53L, G73C, T74P, L89VL10V, T12K, I13A, I15V, L19I, K20I, E34Q, E35D, M36I, N37E, K55R, I62V, L63T, I72VF
 RenG15682RenG15682KT746710PINAI47IV, I50IV, I54V, V82C, L90MM46MV, F53L, L76ML10IV, I15V, G16Q, L19I, K20KR, E35D, M36I, N37ND, P39Q, R41K, K45R, K55R, R57K, Q61DN, L63T, E65D, C67DE, L89MF
 RenG17021RenG17021KT748049PINAV32I, I47V, I50V, I54L, V82ML33F, K43T, T74PL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37S, R57K, Q61N, L63T, E65D, I72V, L89FF
 RenG15968RenG15968KT746996PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG16517RenG16517KT747545PINAM46IV32A, L33FL10V, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65D, I72T, T74A, L89MF
 RenG17332RenG17332KT748360PINAV32I, M46L, I47V, V82FF53LL10I, K20R, E35D, M36I, N37S, R41K, R57K, Q61N, L63T, E65D, A71I, I72T, V77I, I85V, I93LF
 RenG15580RenG15580KT746608PINA  T12S, I15V, L19IV, K20R, E35D, M36I, R41K, L63T, I72T, V82IF
 RenG15949RenG15949KT746977PINAG48A, I54V, L76V, V82A, L90MF53LL10I, I15V, G16GA, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63T, A71V, I72T, T74S, L89M, I93LF
 RenG15848RenG15848KT746876PINAI54L, N88SK43KTL10V, T12TK, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63T, I64V, V77I, L89M, I93LF
 RenG15805RenG15805KT746833PINAI50L, N88S L10M, K14R, I15V, G16E, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, L89MF
 RenG16322RenG16322KT747350PINAI50L, L90ML33F, F53L, T74APL10V, T12TA, I13IV, I15S, G16R, K20R, E34N, E35D, M36I, P39T, R41K, K55KR, R57K, Q61N, L63T, A71AITV, I72T, V77VI, L89MF
 RenG15970RenG15970KT746998PINA  L10IV, I15V, G16GE, E35D, M36I, P39S, R41K, R57K, Q61D, L63T, I72T, I93LF
 RenG15700RenG15700KT746728PINAM46I, I50V, I54V, V82A L10V, T12E, K14KQ, I15V, G16GE, L19LI, K20R, E35D, M36I, N37K, R41K, Q61N, L63T, E65D, I72IT, T74AS, L89MF
 RenG17425RenG17425KT748453PINAD30N, I54VN88DL10Y, T12TA, I15V, G16E, K20R, E35D, M36V, P39Q, R41RK, R57K, D60E, Q61D, L63T, A71V, I72T, L89T, I93LF
 RenG15768RenG15768KT746796PINAM46I, I54V, L76V, V82AL24I, Q58EL10I, T12N, I15V, L19I, K20R, E34G, E35D, M36I, N37D, R41K, R57K, Q61DN, L63T, E65D, I72T, L89MF
 RenG17247RenG17247KT748275PINAL90LM L10I, I13V, K14Q, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, L89MF
 RenG16557RenG16557KT747585PINA  K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, V82I, L89MF
 RenG16968RenG16968KT747996PINAM46L, I54V, L76V, V82A, L90M R8Q, L10I, I15AV, K20R, E35D, M36I, N37G, R41K, R57K, Q61N, L63T, A71V, I72T, L89M, I93LF
 RenG15721RenG15721KT746749PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, L19V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, H69Y, I72T, L89M, I93LF
 RenG16026RenG16026KT747054PINA  R8H, I13V, G17E, E35D, M36I, N37D, R41K, R57RK, Q61DGNS, L63T, I64IV, E65DF
 RenG15943RenG15943KT746971PINA  L10IV, T12TKPQ, I13V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, D60DE, Q61D, L63T, C67*DEYF
 RenG15740RenG15740KT746768PINAM46I, V82AV32A, L33F, F53LL10I, I13V, G16E, K20R, E35D, M36L, R41K, Q61N, L63T, I66F, I72T, T74A, L89MF
 RenG14507RenG14507KT745535PINAM46I, I47V, I54V, V82AF53L, Q58EL10V, K14R, G17E, L19V, K20R, E35D, M36I, N37D, R41RK, K55R, R57K, Q61N, L63T, E65D, I72T, V77I, L89MF
 RenG15080RenG15080KT746108PINAI54IV, V82A L10V, I15V, G17GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, H69Y, I72T, T74S, L89MF
 RenG14016RenG14016KT745044PINAM46I, I54V, L76V, V82A L10I, T12TN, I15V, L19I, K20R, E35D, M36I, R57K, Q61N, L63T, E65D, A71V, I72T, L89M, Q92K, I93LF
 RenG15289RenG15289KT746317PINA  I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, L89MF
 RenG14596RenG14596KT745624PINA  L10LI, T12TP, K14KR, I15V, G16E, E35D, M36I, P39S, R41K, R57K, D60E, Q61D, L63T, C67W, I72TF
 RenG15083RenG15083KT746111PINAM46L, N88S L10V, I15V, G16E, K20R, E35D, M36V, R41K, R57K, Q61N, L63T, E65D, I72TF
 RenG15306RenG15306KT746334PINAM46MI, I54IVL10LF, L33LF, K43T, T74TPSG16GE, K20MR, E35D, M36I, N37ND, R41K, K55R, R57RK, Q61QHKN, L63T, I72IT, V82VDIN, L89LMF
 RenG14415RenG14415KT745443PINAM46ML, I54L, L90ML23LI, F53LL10IV, I15V, G16E, K20T, E35D, M36V, P39PS, R41K, R57K, Q61N, L63T, A71AV, I72T, T74S, I85V, L89IM, I93LF
 RenG15008RenG15008KT746036PINAM46I, I50V, I54V, V82AL24I, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65D, I72T, T74S, L89MF
 RenG14157RenG14157KT745185PINAM46L, G48T, I54V, L76V, V82AF53LI15V, G16E, L19I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, A71V, I72T, I93LF
 RenG14802RenG14802KT745830PINAV82AL24LII15V, G16E, K20R, E35D, M36I, R41K, K45KR, R57K, Q61N, L63T, L89MF
 RenG15231RenG15231KT746259PINAM46L, I50L, V82AL33F, K43TL10V, I15V, G16E, K20R, E35N, M36I, N37NT, P39S, R41K, I62V, L63T, I64V, E65D, A71V, I72T, T74S, I93LF
 RenG14385RenG14385KT745413PINAM46L, G48Q, I54V, L76V, I84VL24IL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92QKF
 RenG13983RenG13983KT745011PINA  L10I, I15V, K20T, E34A, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, E65D, T74A, L89T, I93LF
 RenG15255RenG15255KT746283PINAM46I, I47IV, I54IM, L90ML33F, F53FL, Q58EL10V, I15V, G16E, K20T, E35D, M36IV, P39S, K55R, R57K, Q61N, I62IV, L63T, I72T, T74S, L89MF
 RenG14989RenG14989KT746017PINAI50L, V82AL33F, F53LI13V, I15V, K20R, E35D, M36I, N37IS, R41K, R57K, Q61N, L63T, I64L, K70Q, I72T, T74A, L89MF
 RenG15449RenG15449KT746477PINA  T12V, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, I62IV, L63T, I64M, E65ED, I72T, L89M, I93LF
 RenG13545RenG13545KT744573PINAI54IV, V82VAN88NDI15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, I72T, L89MF
 RenG15039RenG15039KT746067PINAM46I, G48S, I54S, V82ML24I, K43TL10V, L19IV, K20R, E35D, M36I, R41K, F53Y, K55Q, R57K, D60DN, Q61DN, I62V, L63T, I64V, E65D, I72T, T74AF
 RenG14743RenG14743KT745771PINA  L10I, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63T, V77I, L89M, I93LF
 RenG14088RenG14088KT745116PINA  I13V, E35D, M36I, R41K, Q61N, L63T, E65D, I72T, L89MF
 RenG14692RenG14692KT745720PINA  E35D, M36I, R41K, R57RK, D60E, Q61E, I62V, L63T, E65D, I72T, L89MF
 RenG14806RenG14806KT745834PINA  K14R, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, I62IV, L63T, E65D, V77VI, L89MF
 RenG15277RenG15277KT746305PINAL90M I15V, G16E, K20T, E35D, M36I, P39PS, R41K, R57K, Q61N, L63T, E65D, I72TF
 RenG14546RenG14546KT745574PINAL90M L10V, I15V, G16E, K20R, E35D, M36V, R41K, R57K, Q61N, I62V, L63T, I72T, V77I, L89M, I93LF
 RenG13884RenG13884KT744912PINAM46I, I54V, L76V, V82AL10FIK14KR, G17D, L19I, K20R, E35D, M36I, N37NDEK, R41RK, R57K, Q61N, L63T, E65D, I72T, L89MF
 RenG15068RenG15068KT746096PINAI50L, V82AL33F, F53FLT12I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, L63T, A71V, T74SF
 RenG15021RenG15021KT746049PINAM46L, I54LV, L76V, V82AL33FL10V, I13IV, G16E, L19V, K20R, E35D, M36I, N37DE, P39PQ, K55R, R57K, Q61N, L63T, E65D, I72V, T74S, L89MF
 RenG13719RenG13719KT744747PINA  L10V, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, H69Y, I72TF
 RenG15072RenG15072KT746100PINAM46L, I54V, L76V, V82A, L90ML33F, Q58EL10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77IF
 RenG14197RenG14197KT745225PINAM46I, V82AL24I, K43T, T74PL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, I72T, L89MF
 RenG14993RenG14993KT746021PINAM46I, I54V, L76V, V82AQ58EL10LR, T12A, K14R, I15V, G16E, E35N, M36IV, N37D, R41K, K55R, R57K, D60E, Q61D, L63T, I72T, L89MF
 RenG12432RenG12432KT743460PINAM46L, I54V, I84VL24I, G48EL10I, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92KF
 RenG13070RenG13070KT744098PINAD30N T12T*KS, I13V, K14R, I15AV, K20T, E35N, M36I, N37ND, R41K, K45Q, Q61N, L63T, I72T, V77IF
 RenG13470RenG13470KT744498PINAM46I, I54V, L76V, V82A L10IV, I13IV, I15V, G16E, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, L63T, E65D, I72V, T74S, V77I, L89MF
 RenG13058RenG13058KT744086PINAM46I, I54A, V82M, L90ML33F, T74PL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, R57K, Q61N, L63T, I64V, H69S, L89MF
 RenG12397RenG12397KT743425PINA  W6GR, I15V, E35D, M36I, R41K, R57K, Q61N, L63T, I72T, T74S, V77I, L89MF
 RenG12585RenG12585KT743613PINAM46I, I47V, I54V, V82AK43KTL10V, I15V, G16AE, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72TF
 RenG12629RenG12629KT743657PINA  T12KN, I15V, L19I, K20R, E35D, M36I, P39Q, R41K, R57K, Q61D, L63T, I72T, T74S, L89MF
 RenG12824RenG12824KT743852PINAD30N, M46L, I54V, V82AL33I, F53L, N83D, N88DL10I, I13V, G16E, K20R, A22V, E35N, M36I, N37T, K45R, R57K, Q61N, L63T, E65D, A71V, I72T, T74S, V75I, L89M, Q92KF
 RenG12901RenG12901KT743929PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG12160RenG12160KT743188PINA  K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, I72T, L89MF
 RenG11848RenG11848KT742876PINA Q58EI15V, E35D, M36I, P39Q, R41K, R57K, D60E, Q61N, L63T, I72V, T74S, L89MF
 RenG13508RenG13508KT744536PINA  I15V, G17E, K20R, E35D, M36I, R41K, R57K, Q61D, L63T, E65D, I72T, L89MF
 RenG11967RenG11967KT742995PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG13135RenG13135KT744163PINA  L10V, I15V, G16E, K20R, E35D, M36I, P39PS, R41K, R57K, Q61N, L63T, E65D, H69Y, I72T, T74TAF
 RenG13168RenG13168KT744196PINA  I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, L89MF
 RenG12402RenG12402KT743430PINA  W6WR, T12I, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, I72T, L89MF
 RenG12458RenG12458KT743486PINAL90M L10V, G16E, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65ED, I72V, V77I, L89M, I93LF
 RenG12893RenG12893KT743921PINAM46I, I50V, I54V, V82A, L90MQ58EL10V, I15V, G16E, K20R, E35D, M36V, P39S, R41K, K55R, R57K, D60E, Q61N, L63T, E65D, A71V, I72T, V77VI, L89M, I93LF
 RenG12097RenG12097KT743125PINA  L10V, T12I, I15V, G16E, E35D, M36I, R41K, K43KR, R57K, D60E, Q61N, L63T, I72T, T74S, L89MF
 RenG12253RenG12253KT743281PINAV32I, I54LK43T, F53L, L89VL10V, I13V, K20R, E34D, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, A71VF
 RenG12448RenG12448KT743476PINAV32VI, M46I, I47IV, I50L, I54V, V82SF53FL, L76LML10I, K14R, I15V, G16E, K20R, E34EA, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, E65D, A71V, I72T, T74A, L89M, I93LF
 RenG12215RenG12215KT743243PINA  I15V, E35ED, M36I, P39Q, R41K, D60E, Q61D, L63T, E65D, I72IT, L89MF
 RenG12711RenG12711KT743739PINA  T12E, I15V, M36I, N37E, R57K, D60E, Q61N, L63T, I72T, L89MF
 RenG11377RenG11377KT742405PINAL90M L10V, T12I, Q18E, E35D, M36IV, R41K, R57K, Q61N, I62V, L63T, I64V, I72T, T74S, I93ILF
 RenG10683RenG10683KT741711PINAM46I, I54V, N88SL33I, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I93LF
 RenG11011RenG11011KT742039PINAL90LM L10LI, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, H69HQ, I72T, L89MF
 RenG11382RenG11382KT742410PINA  L10I, K14KE, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63T, C67H, L89MF
 RenG11609RenG11609KT742637PINAM46I, V82A W6WL, L10V, T12N, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, L63T, E65D, H69Q, I72TF
 RenG11620RenG11620KT742648PINA  I15V, G16E, E35D, M36I, P39T, R41K, R57K, Q61N, L63T, E65D, I72TF
 RenG10556RenG10556KT741584PINAM46I, I54V, L76V, V82AK43TL10I, K14R, I15V, G16GA, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, I62V, L63T, H69HY, I72T, L89M, I93LF
 RenG10391RenG10391KT741419PINA  T12M, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, G68E, H69R, I72TF
 RenG11198RenG11198KT742226PINA Q58EL10I, K20M, E35D, M36I, R41K, R57K, Q61N, L63T, I72V, L89M, I93LF
 RenG10401RenG10401KT741429PINA  T12S, I15V, Q18E, L19T, K20R, E35D, M36I, R57K, Q61D, L63T, E65D, I72TF
 RenG11316RenG11316KT742344PINAI54V, V82A L10I, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I72T, T74S, L89M, I93LF
 RenG11415RenG11415KT742443PINA  T12TA, K14KR, I15V, E35D, M36I, R41K, R57K, Q61D, L63T, L89MF
 RenG10695RenG10695KT741723PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, H69Y, I72T, L89MF
 RenG11039RenG11039KT742067PINA  E35D, M36I, P39PS, R41K, R57K, Y59YH, Q61N, I62IV, L63T, I64V, I72VF
 RenG11532RenG11532KT742560PINAG48A, I54A, V82A W6W*, L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36V, N37K, R41K, R57K, Q61N, L63T, I72T, T74S, L89MF
 RenG11264RenG11264KT742292PINA  L10I, G17D, K20R, M36I, R57K, Q61N, L63T, C67Y, P79AF
 RenG10716RenG10716KT741744PINA  I15V, Q18E, E35D, M36I, P39PS, R41K, R57K, Q61N, L63T, K70R, I72IT, L89MF
 RenG10170RenG10170KT741198PINAM46L, I54V, V82A L10I, I13V, G16E, K20R, M36I, N37ND, R41K, Q61N, L63T, I64IL, E65ED, L89MF
 RenG10367RenG10367KT741395PINAL90LM T12M, L19Q, K20KR, E35D, M36I, R41K, D60E, Q61DN, I62IV, L63T, I72T, T74TA, L89M, I93ILF
 RenG11119RenG11119KT742147PINAI50LL33LF, F53LG17E, K20R, E35D, M36I, N37DE, R41K, K43R, K45N, R57K, D60N, Q61N, L63T, I72T, V82VI, L89MF
 RenG10848RenG10848KT741876PINAV32I, M46I, I47V, I54V, V82AK43T, F53L, G73GCL10V, T12K, I15V, G16E, L19LI, K20R, E34Q, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, V77ILF
 RenG10504RenG10504KT741532PINAN88S L10LV, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, E65D, V77I, L89M, Q92KF
Jenabian (2015)DR46DR46KF735849PINA  L10V, K14R, I15IV, G16GE, L19I, E35X, M36I, N37D, R41RK, K45R, R57RK, L63T, H69K, K70KR, L89XF