<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63S
Rx PI-naive
IncludeMixtures No
References 40
Patients 118
Isolates 118
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Vergne (2000)95cm-mp25795cmmp257AJ249237None   L10V, I15V, K20R, E35D, M36I, R41K, I62V, L63S, H69Q, L89MF
Brindeiro (2002)TVGG13TVGG13AY145824None   I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63S, L89MF
Brindeiro (2003)BRP2138BRP2138AY213435None   T4S, L5P, Q7Y, L10N, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63S, L89MF
 BRP2117BRP2117AY213397None   I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63S, I64LF
Eshleman (2004)ABB66ABB66AY444281None   L10V, I15V, E35D, M36I, P39S, R41K, I62V, L63S, H69Q, L89MF
 3781137811AY444273None   K14R, I15V, G17E, E35D, M36I, R57K, Q61N, I62V, L63S, L89MF
Machado (2004)N76N76AY569901None   T12M, E35D, M36I, R41K, R57K, Q61N, L63SF
Machado (2004)cs122cs122AY313300None   T12R, L19I, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, L89M, C95SF
 cs157cs157AY313311None   L10V, E35D, M36I, R41K, Q61N, L63S, E65D, V77I, L89MF
Non-B Workgroup (2005)BR36BR36AY900876None   Q2P, L10V, E35D, M36I, R41K, Q61N, L63S, V77I, L89MF
 BR1052BR1052AY900940None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, I72T, C95SF
 BR1060BR1060AY900948None   I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63S, I64LF
Rodrigues (2005)BLF_Pat7BR03SP270AY643172None   I15V, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, L63S, H69Y, L89MF
de Sa Filho (2006)BREPM12817BREPM12817DQ085874None   L10I, I13V, G16E, L19P, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
Laurent (2006)CK2-7602CM-76AM279447None   L10I, I13V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63S, H69Q, L89MF
Santos (2006)F1021PRF1021PRDQ191031None   G17E, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, H69Y, L89MF
Dilernia (2007)F023F023EF120085None   I15V, K20R, T31TA, E35D, M36I, R41K, R57K, Q61N, L63S, I64M, V75IF
 F003F003EF120340None   I15V, L19I, E35D, R41K, R57K, Q61N, L63S, I93LF
Rios (2007)CH122MR_CH122EF194024None  K43TT12K, I15V, L19I, E35D, M36I, R57K, Q61D, L63SF
Lloyd (2008)CR07503HN_CR075EU312668None   L10I, K20R, E35D, M36I, R41K, I62V, L63S, H69Q, K70R, A71AV, I72IT, L89MF
Palacios (2008)1257912579 None   G16E, K20KM, E35D, M36I, R41K, R57K, Q61N, L63S, I64L, H69Y, I72T, L89LMF
Cardoso (2009)BRGO3001BRGO3001FJ548786None   E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89MF
 BRGO3015BRGO3015FJ548798None   I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 BRGO3076BRGO3076FJ594144None   I15V, G17D, K20R, E35D, M36I, R41K, R57K, Q61N, L63SF
Cuevas (2009)X2632_1X2632_1GU326158None   L10V, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, L89MF
Ferreira (2010)P31DIP31GQ862307None   L10I, I13V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63S, K70R, T80Q, L89MF
 P49DIP49GQ862308None   L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, V77I, L89MF
Yebra (2010)40134007SP401340FJ481662None   L10I, E35D, M36I, R41K, R57K, Q61N, L63S, C67S, H69Q, V77VIF
Charpentier (2011)CR-4CR-4FJ688211None   L10I, I15V, K20R, E35D, M36I, R41K, I62V, L63S, C67Y, H69Q, L89MF
Ferreira (2011)BRMT2526BRMT2526HQ638704None   L10I, Q18L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89M, I93LF
 BRMT2558BRMT2558HQ638710None   I15IV, E35D, M36I, R41K, R57K, Q61D, L63S, E65D, L89MF
 BRMT722BRMT722HQ638765None   L10V, Q18L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89MF
 BRMT2176BRMT2176HQ638789None   R41K, R57K, Q61N, I62IV, L63S, I64M, C67CG, I72TF
Florea (2011)4294_20074294_2007JQ083058None   T12P, K14R, I15V, E35D, M36I, R41K, R57K, L63S, L89MF
Kousiappa (2011)CY212CY212JF683762None   L10V, K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, H69Q, V77I, L89MF
Santos (2011)J76J76_PR_RTJN010454None   G17E, K20R, M36I, R41K, R57K, Q61N, L63S, H69Y, L89MF
 J193J193_PRJN010597None   T12E, K14R, E35D, M36I, R41K, R57K, Q61N, L63S, I64L, I72T, L89M, I93LF
Caron (2012)Gab082183Gab082183HQ541936None   L10V, T12N, I15V, K20R, E35D, M36I, R41K, I62V, L63S, L89M, I93LF
Gaspareto (2012)CLPG59CLPG59PTHM752181None   L10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89MF
Oliveira (2012)05CVHAN3205CVHAN32JF267449None   T12K, I13V, L19I, E35D, M36I, R57K, L63S, L89MF
Alencar (2013)MG2-0010MG2-0010JQ237983None   I13V, I15V, E35D, M36I, P39Q, R41K, K45R, R57K, Q61N, L63S, I64LF
 RJ2-0044RJ2-0044JQ238060None   T12N, K14R, L19I, M36I, R57K, Q61S, L63S, I64VF
 RJ2-0046RJ2-0046JQ238061None   L10I, T12E, I15V, E35DN, M36I, R41K, Q61N, L63S, C67E, K70R, I72T, L89MF
 PE2-0086PE2-0086JQ238175None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, L89M, I93LF
Frentz (2013)EHR-61454EHR-61454JX300566None   L10V, K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, H69Q, V77I, L89MF
 EHR-72094EHR-72094JX300761None   T12P, K14R, I15V, E35D, M36I, R41K, R57K, L63S, L89MF
Temereanca (2013)SR51SR51JX966524None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 SR53SR53JX966525None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 SR61SR61JX966528None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 SR63SR63JX966529None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 SR64SR64JX966530None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
Niculescu (2014)DU4287DU4287KJ194785None   L10IV, T12TI, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3631bhDU3631bhKJ194826None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2685bhDU2685bhKJ194811None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3667DU3667KJ194801None   L10V, I13V, I15V, G16GE, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2986DU2986KJ194772None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU159DU159KJ194738None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2624bhDU2624bhKJ194807None  L33IVL10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU2130DU2130KJ194800None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1360DU1360KJ194755None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2623bhDU2623bhKJ194806None   L10V, I13V, I15V, L33V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU5407DU5407KJ194794None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89M, L90LVF
 DU3433bhDU3433bhKJ194817None   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1400DU1400KJ194799None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2749bhDU2749bhKJ194813None   L10V, I13V, I15IV, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU837DU837KJ194750None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU505DU505KJ194747None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1639DU1639KJ194757None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1642DU1642KJ194758None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, D60E, Q61H, L63S, E65D, L89MF
 DU241DU241KJ194740None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1236DU1236KJ194753None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2985DU2985KJ194771None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3268DU3268KJ194780None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU388DU388KJ194743None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2989DU2989KJ194774None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU4817DU4817KJ194789None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU2983DU2983KJ194770None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU2439DU2439KJ194763None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q58K, Q61H, L63S, E65D, L89MF
 DU3923DU3923KJ194784None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89M, I93DF
 DU2981DU2981KJ194768None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3266DU3266KJ194779None   L10V, I13EG, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2990DU2990KJ194775None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU5894DU5894KJ194735None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU5388DU5388KJ194791None   L10V, I13V, I15IV, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU136DU136KJ194737None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU457DU457KJ194744None   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2988DU2988KJ194773None  V11IL10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU458DU458KJ194745None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3270DU3270KJ194781None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, I62V, L63S, E65D, L89MF
 DU3474bhDU3474bhKJ194821None   L10V, I13V, K14E, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2982DU2982KJ194769None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU5812DU5812KJ194796None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2680bhDU2680bhKJ194810None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU4514DU4514KJ194787None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, I72V, L89MF
 DU3403DU3403KJ194782None   I3V, L10V, I13V, I15V, D25E, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2516DU2516KJ194765None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, Q61H, L63S, E65D, L89MF
 DU2229DU2229KJ194762None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3632bhDU3632bhKJ194827None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU3067bhDU3067bhKJ194815None   L10V, I13V, I15IV, E35D, M36I, R41K, K45R, F53FC, R57K, L63S, E65D, L89MF
 DU111DU111KJ194736None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU1285DU1285KJ194754None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2686bhDU2686bhKJ194812None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU5241DU5241KJ194802None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89M, G94CF
 DU182DU182KJ194739None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2905DU2905KJ194767None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU4804DU4804KJ194788None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
Velasco-de-Castro (2014)06BRRJRS14206BRRJRS142KF922152None   I15V, E35D, N37Q, R41K, Q61H, L63S, I64VF
Bruzzone (2015)HM0141FHM0141FKP889065None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, D60DG, Q61N, L63S, H69S, I72TF
Guimaraes (2015)BRSP627-14BRSP627-14KP115553None   K14R, I15V, E35D, M36I, N37E, R57K, Q61N, L63S, E65DF
 BRSP433-12BRSP433-12KP115440None   I15V, E35D, M36I, R41K, R57RK, Q61N, L63S, I64IL, L89MF
Hora (2015)DEMBF09ES003DEMBF09ES003JX140660None   L10V, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, L89MF
Kouri (2015)C_AIDS19C_AIDS19KP688144None   L10I, I13V, G16E, K20KR, E35D, M36I, R57K, Q61E, L63S, H69Q, K70R, L89MF
Pessoa (2015)10BR_MG010MG010KJ849787None   I13V, I15V, E35D, M36I, P39Q, R41K, K45R, R57K, Q61N, L63S, I64LF
 10BR_RJ046RJ046KJ849809None   L10M, T12V, I13V, I15V, E35D, M36I, R41K, Q61N, L63S, C67E, K70R, I72T, L89MF
Lam (2016)20420062042006KR867971None   T12I, I13V, I15V, E35D, M36I, R41K, K43R, R57K, Q61D, L63S, I72TF
Lima (2016)08PE07508PE075KX021010None   T12E, I15V, L19I, E35D, M36I, R41K, R57K, D60E, Q61N, L63S, L89MF
 08PE06208PE062KX021018None   L10I, T12N, I15V, G16E, E35D, M36I, P39Q, R41K, R57K, Q61D, L63S, I72V, L89M, I93LF
Pessoa (2016)10BR_RJ04410BR_RJ044KT427776None   T12N, K14R, L19I, M36I, R57K, Q61S, L63S, I64VF