<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63S
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 68
Isolates 68
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
de Sa Filho (2003)BREPM174BREPM174AY182828IDV V32I, M46L, V82A L10I, G16E, N37S, R41K, R57K, Q61D, L63S, E65D, A71VF
Gomez-Carrillo (2004)9246292462AY365478PINAI54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57RK, Q61N, L63S, I64L, I72T, I93LF
 9386793867AY365491PINAM46I, V82A, I84V Q7QH, L10I, T12TP, I15V, K20R, E35D, M36I, N37D, R41K, K43KN, R57K, Q61N, L63S, E65D, T74S, I93LF
 9479594795AY365503PINA  T12A, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 100161100161AY365609PINA  I15V, G16GE, K20M, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, K70KR, I72TF
 100799100799AY365620PINAM46I, I54V, I84VN83DL10IV, I13V, I15V, E35D, M36I, N37DE, R41K, R57K, Q61N, L63S, I64VF
 102704102704AY365658PINAM46I, I54V, V82TL24IL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, T74S, I93LF
 105344105344AY365724PINA  L10V, K14KR, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, L89LMF
 106671106671AY365754PINAM46I, I50V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20R, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 109988109988AY365828PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, V77I, I93LF
 112128112128AY365856PINA  I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, I93LF
 114305114305AY365896PINAD30NQ58E, N88DL10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72V, V77I, I93LF
 115099115099AY365916PINA  K14R, I15V, E35D, M36I, R41K, R57K, Q61D, I62IT, L63S, I64IL, E65ED, I72KF
 118072118072AY365942PINA  L10LV, K14R, I15V, Q18L, L19I, M36I, R41K, R57K, Q61N, I62V, L63S, E65D, I72TF
 119381119381AY365963PINA  Q7D, K14KR, I15V, G17GE, E35D, M36I, R41K, R57RK, D60DE, Q61N, I62V, L63SF
 119804119804AY365974PINAM46L, G48V, I54V, L76V, V82A, L90ML33F, K43TL10I, I15V, G16E, K20M, E35H, M36L, R41K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 122744122744AY366015PINAM46I, I50V, I54V, V82AF53L, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, K55R, R57K, Q61N, L63S, E65D, K70T, A71V, I72E, L89M, I93LF
 125487125487AY366047PINA  T12Q, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63SF
 125870125870AY366050PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
de Sa Filho (2005)BREPM275BREPM275AY771592PINAD30NL33F, N88DL10V, T12K, I13V, I15V, K20T, E35D, M36L, N37E, K55R, R57K, D60E, Q61N, L63S, L89MF
Rodrigues (2005)BLF_Pat19BR02SP234AY643143SQV, IDV223  I15V, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, I72VF
Baxter (2006)48-10191019-30619DQ877325PINAG48V, I54V, V82AF53LL10I, I15V, K20R, E35D, M36I, R41K, Q61N, I62IV, L63S, I64L, I72T, T74S, L89M, I93LF
 48-10741074-30626DQ877334PINAV32I, M46I, I47V, I54V, V82A, L90LML24I, L33F, T74PSL10I, I13IV, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63S, E65D, A71AV, V77I, L89M, Q92QK, I93LF
 48-11031103-30708DQ877410PINAM46L, I54V, L76V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20M, E35H, M36L, R41K_K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, L89LM, I93LF
 48-61196119-30924DQ878705PINAM46L, I54V, V82AL24IL10V, T12P, G17D, K20R, E35D, M36I, R57K, Q61N, L63S, I72T, L89MF
Sanabani (2006)01BR32301BR323DQ358804PINA  L10V, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, L89MF
Dumans (2009)RENA304RENA304FJ405138SQV, IDV209  K14R, I15V, E35D, M36I, N37D, R57K, Q61N, L63SF
 RES167_03RES167_03FJ405161IDV, NFV248  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63SF
 RENA651RENA651FJ405167RTV, IDV300M46L, I54V, V82A L10V, T12I, I13V, I15V, G16E, K20R, N37S, R57K, Q61N, L63S, E65D, L89MF
Aulicino (2011)4339-O131MJL4339-O131MJLHQ158160PINAD30N T12P, K14R, K20T, E35D, M36I, R41K, K45Q, R57K, Q61N, L63S, T74S, I93LF
 4656-N883LM4656-N883LMHQ158184PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61D, L63S, I93LF
 3226-L4953226-L495HQ158270PINAL90M K20T, E35D, M36I, R41K, R57K, D60E, Q61N, L63S, N98KF
Jones (2012)131016131016JN669499PINAM46L, I54V, V82SL24IL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, A71V, I72T, I93LF
 134851134851JN669533PINA  L10I, T12TA, K14R, I15V, E35D, M36I, P39PL, R41K, R57K, Q61N, L63S, I72IT, I93LF
 156299156299JN669858PINAM46L, I54V, V82SL24IL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, A71V, I72T, I93LF
 159284159284JN669948PINA  L10V, I13V, I15V, G16E, E35D, R41K, R57K, D60E, Q61N, L63S, K70KRF
 160334160334JN669974PINA  I15V, E35D, M36I, R41K, R57K, Q61DN, L63S, I72ITF
 161478161478JN670009PINA  T12K, I15V, L19IT, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 164791164791JN670083PINA  I15V, G16E, K20R, E35D, M36I, P39S, R41K, K43R, R57K, Q61N, L63S, I72TF
 167067167067JN670142PINAV82AF53FLL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 170847170847JN670237PINAD30DN I15V, K20KT, E35D, M36I, R41K, W42W*, K45KR, R57K, Q61N, L63S, E65D, I72TF
 170913170913JN670240PINAN88NS L10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I62V, L63S, I93LF
 171144171144JN670247PINAL90M I15V, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72IT, G86GEF
 171629171629JN670263PINAV32I, M46I, I54V, V82A, L90LM L10I, K20R, E35D, M36I, N37ND, R41K, K43KI, R57K, Q61N, L63S, A71V, I72TF
 175401175401JN670357PINA  T12A, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 175949175949JN670381PINA  I15V, M36I, R41K, R57K, Q61N, L63S, E65ED, I72ITF
 179452179452JN670510PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63SF
 180121180121JN670537PINA  I15V, E35D, M36I, N37D, R41K, R57K, Q61N, L63S, I93LF
 180384180384JN670546PINAD30N I15V, K20T, E35N, M36I, R41K, K45Q, R57K, Q61N, L63S, E65DF
 181788181788JN670587PINAM46L, I54V, V82AL24IL10I, T12N, I15V, L19I, E35D, M36I, R41K, K55KR, Q61N, L63S, A71VF
 184574184574JN670683PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 188046188046JN670747PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, T74A, I93LF
 189223189223JN670767PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I64L, K70T, I72IT, I93LF
 189584189584JN670777PINA  L10LI, I15V, G17E, L19IT, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, I93LF
 190055190055JN670787PINAL90M I15V, G16E, K20M, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I93LF
 191048191048JN670808PINAM46I, I50V, I54V, V82AL33FL10V, K14KR, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72V, T74S, L89MF
 192843192843JN670868PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 194783194783JN670949PINA  I15IV, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 195288195288JN670974PINA  I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, I64L, I72ITF
 195729195729JN670999PINA  L10I, T12TIM, I15V, E35D, M36I, N37D, R41K, K43KR, R57K, Q61N, L63S, E65D, I93LF
 195796195796JN671001PINA  T12A, I15V, M36I, R41K, R57K, Q61N, L63S, I72IT, I93LF
 196628196628JN671029PINAV32I, M46I, I54V, V82C, L90M L10I, Q18E, K20R, E21EG, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, T74S, L89M, I93LF
 198184198184JN671110PINAD30NN88DI13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, A71T, I72M, Q92RF
 198911198911JN671139PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72ITF
 200414200414JN671201PINAL90M L10I, I15V, E35D, M36IT, R41K, R57K, Q61N, L63S, E65D, A71V, I72ITF
 202696202696JN671286PINA  L10I, T12P, E35D, M36I, N37D, R41K, R57K, D60E, Q61D, L63S, E65D, A71T, I72IT, V77I, I93LF
 204754204754JN671350PINAM46I, I50V, I54V, V82AL33F, Q58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
Grossman (2014)991991KF135177RTV, LPV52  I15V, L19I, E35D, M36I, P39Q, R41K, R57K, D60E, Q61D, L63S, L89MF