<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63S
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 70
Isolates 70
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
de Sa Filho (2003)BREPM174BREPM174AY182828IDV V32I, M46L, V82A L10I, G16E, N37S, R41K, R57K, Q61D, L63S, E65D, A71VF
Gomez-Carrillo (2004)105344105344AY365724PINA  L10V, K14KR, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, L89LMF
 118072118072AY365942PINA  L10LV, K14R, I15V, Q18L, L19I, M36I, R41K, R57K, Q61N, I62V, L63S, E65D, I72TF
de Sa Filho (2005)BREPM275BREPM275AY771592PINAD30NL33F, N88DL10V, T12K, I13V, I15V, K20T, E35D, M36L, N37E, K55R, R57K, D60E, Q61N, L63S, L89MF
Rodrigues (2005)BLF_Pat19BR02SP234AY643143SQV, IDV223  I15V, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, I72VF
Baxter (2006)48-61196119-30924DQ878705PINAM46L, I54V, V82AL24IL10V, T12P, G17D, K20R, E35D, M36I, R57K, Q61N, L63S, I72T, L89MF
Sanabani (2006)01BR32301BR323DQ358804PINA  L10V, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, L89MF
Waleria-Aleixo (2008)08PR06056408PR060564FJ591479PINAN88S L10I, I13V, Q18L, K20T, E35D, M36I, R41K, R57K, Q61N, I62IV, L63S, I64IV, E65D, I72T, L89MF
Dumans (2009)RENA651RENA651FJ405167RTV, IDV300M46L, I54V, V82A L10V, T12I, I13V, I15V, G16E, K20R, N37S, R57K, Q61N, L63S, E65D, L89MF
Aulicino (2011)4396-L592FMC4396-L592FMCHQ158171PINAM46I, I54V, V82A L10I, I15L, L19V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, L63SF
Jones (2012)161478161478JN670009PINA  T12K, I15V, L19IT, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 164791164791JN670083PINA  I15V, G16E, K20R, E35D, M36I, P39S, R41K, K43R, R57K, Q61N, L63S, I72TF
 165635165635JN670109PINAM46I, I54V, V82A L10I, I15L, L19V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, L63SF
 178294178294JN670479PINA  I15V, M36I, N37E, K43KR, R57K, Q61N, L63S, E65D, I72TF
 181788181788JN670587PINAM46L, I54V, V82AL24IL10I, T12N, I15V, L19I, E35D, M36I, R41K, K55KR, Q61N, L63S, A71VF
 184478184478JN670679PINAM46I, I54V, V82A L10LI, I15IM, G16E, K20R, M36I, N37D, K55KR, R57K, Q61N, L63S, E65D, I72TF
 184574184574JN670683PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 191048191048JN670808PINAM46I, I50V, I54V, V82AL33FL10V, K14KR, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72V, T74S, L89MF
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TF
 204754204754JN671350PINAM46I, I50V, I54V, V82AL33F, Q58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
Grossman (2014)991991KF135177RTV, LPV52  I15V, L19I, E35D, M36I, P39Q, R41K, R57K, D60E, Q61D, L63S, L89MF
Diaz (2015)RenG16391RenG16391KT747419PINA  I15V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63S, E65D, T74S, L89MF
 RenG15560RenG15560KT746588PINA  L10V, I15V, G16E, E35D, M36I, P39T, R57K, Q61N, L63S, I72T, L89MF
 RenG16598RenG16598KT747626PINA  K14R, G17GE, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, E65D, L89MF
 RenG16869RenG16869KT747897PINAM46L, I54V, V82A, L90ML33IL10V, T12K, I13V, K20R, E35D, M36I, R41K, F53I, K55N, R57K, D60E, Q61N, I62V, L63S, A71T, L89I, Q92KF
 RenG17352RenG17352KT748380PINA  L10V, T12TIM, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
 RenG16812RenG16812KT747840PINA  L10I, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, I72T, V77I, L89M, I93LF
 RenG15851RenG15851KT746879PINAI54V, V82A L10V, I15V, K20R, E35D, M36I, N37ND, R41K, R57K, Q61N, I62V, L63S, E65D, I72V, T74S, I93LF
 RenG16090RenG16090KT747118PINA  L10I, T12I, I13V, G16E, K20KR, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
 RenG15685RenG15685KT746713PINA  T12TI, E35D, M36I, R41K, K45R, R57K, Q61D, L63S, I72VF
 RenG14876RenG14876KT745904PINA  T12S, I13V, K14R, I15V, Q18M, E35D, M36I, R41K, R57K, D60E, Q61D, L63S, I72T, L89MF
 RenG14656RenG14656KT745684PINAM46I, I54V, L90LMN88GL10IV, I13IL, K14R, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, A71V, I72TF
 RenG15499RenG15499KT746527PINAM46L, I50L, V82AL33FT12TS, I13IV, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
 RenG14309RenG14309KT745337PINAM46I, I54V, L90LMN88GL10IV, I13IL, K14R, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, A71V, I72TF
 RenG14581RenG14581KT745609PINA  T12K, K14I, I15V, L19I, E35D, M36I, R41K, Q61N, L63S, E65DF
 RenG13841RenG13841KT744869PINA  T12TKPQ, K14Q, K20R, E35D, M36I, N37ND, R41K, R57RK, D60E, Q61N, I62V, L63S, E65EDKN, L89LMF
 RenG14854RenG14854KT745882PINA  I13V, I15V, L19Q, E35D, R41K, R57K, Q61N, L63S, I64L, L89MF
 RenG15172RenG15172KT746200PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, F53L, T74PL10I, I13V, G16GDE, K20R, E34A, E35D, M36I, R41K, K45KR, K55R, R57K, Q61N, L63S, C67E, I72V, V77IF
 RenG14660RenG14660KT745688PINA  E35D, M36I, R41K, R57K, Q61N, L63S, I64L, H69Y, I72T, L89MF
 RenG14608RenG14608KT745636PINA  E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63S, E65D, L89MF
 RenG15325RenG15325KT746353PINAM46I, I54V, V82AL24I, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61DN, I62V, L63S, A71AV, L89M, I93LF
 RenG13606RenG13606KT744634PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72TF
 RenG14774RenG14774KT745802PINA  T12A, I15V, L19I, E35D, M36L, R41K, R57K, Q61N, L63SF
 RenG13954RenG13954KT744982PINAM46L, G48V, I54V, V82SL33IL10I, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, L89MF
 RenG15019RenG15019KT746047PINAI50L, V82L, N88SL33FI13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, T74A, L89MF
 RenG15423RenG15423KT746451PINA  T12V, I15V, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, L63S, I64L, L89MF
 RenG12003RenG12003KT743031PINA  L10LV, T12I, I15IV, G16E, M36I, R57K, Q61N, L63S, I72T, L89M, I93ILF
 RenG12319RenG12319KT743347PINAI54IV, L90ML33IL10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
 RenG13532RenG13532KT744560PINAD30N, M46L, I54IV, V82A, L90ML33F, F53L, N88DL10V, T12Q, I13V, I15V, G16GE, K20R, E35D, M36I, R41K, K55KN, Q61N, L63S, I93ILF
 RenG13395RenG13395KT744423PINAM46I, I54V, L76V, L90MQ58QET12K, I15V, G16E, K20T, E35D, M36I, N37E, R57K, D60E, Q61N, L63S, H69HR, L89IF
 RenG12506RenG12506KT743534PINA  L10I, E35D, M36I, R41K, Q61N, L63S, I72T, V77I, L89MF
 RenG13181RenG13181KT744209PINA  L10V, G16E, E35D, M36I, N37D, P39S, R57K, D60E, Q61N, I62V, L63S, I72V, V77I, L89MF
 RenG11943RenG11943KT742971PINA  I15V, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63S, E65D, I72VF
 RenG12340RenG12340KT743368PINAM46L, I50L, V82VA, N88SL33FL10V, I13V, I15IV, G16E, K20R, E35D, M36I, N37S, P39P*QS, R41K, K45R, R57K, Q61N, L63S, I64IV, I72TF
 RenG11946RenG11946KT742974PINAM46L, N88SQ58EL10V, K20T, E35D, M36I, R57K, Q61N, I62V, L63S, E65D, I72T, V77I, L89M, I93LF
 RenG12124RenG12124KT743152PINA  Q18M, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, K70R, I72T, V77VI, L89MF
 RenG12672RenG12672KT743700PINAV32I, I47A L10V, I13V, G16E, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63S, A71AT, I72E, V82I, L89IF
 RenG13341RenG13341KT744369PINA  T12K, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63S, E65DF
 RenG12739RenG12739KT743767PINAI54V, V82AL24IL10I, I15V, K20R, E35D, M36I, N37ND, R41K, K55KR, R57K, Q61N, L63S, E65D, T74TS, L89MF
 RenG10320RenG10320KT741348PINA  L10LV, I15V, E35D, M36I, P39PQ, R41K, R57K, Q61N, L63SF
 RenG11199RenG11199KT742227PINA  T12D, K14R, I15V, K20R, M36I, R41K, R57K, Q61N, L63S, H69HY, I72IT, L89MF
 RenG11155RenG11155KT742183PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63S, L89MF
 RenG10567RenG10567KT741595PINAI54A, V82A L10I, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, L63S, I64IL, A71V, I72IT, I93LF
 RenG11402RenG11402KT742430PINA  T12N, I15V, L19I, N37E, Q61N, L63S, P79S, V82I, L89IF
 RenG11762RenG11762KT742790PINA  I15V, L19V, K20R, E35D, M36I, R41K, R57K, Q61S, L63S, K70R, I72IT, L89MF
 RenG10068RenG10068KT741096PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, E35D, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63S, L89MF
 RenG10389RenG10389KT741417PINA  G16E, E35D, M36V, R41K, R57K, Q61N, L63S, E65D, I72T, L89MF
 RenG10532RenG10532KT741560PINA  T12I, I15V, Q18E, E35D, M36I, R41K, R57K, Q61N, L63S, I64IM, L89MF
 RenG10996RenG10996KT742024PINAM46L, V82A L10V, T12N, I15V, L19I, K20R, M36I, N37E, R41K, I62V, L63S, H69Q, L89LMF
 RenG10060RenG10060KT741088PINAM46I, I50IL, I54V, V82AL24I, L33LF, K43TL10I, I15V, K20R, E35D, M36IV, R41K, R57K, Q61N, I62V, L63S, H69C, I72T, T74S, L89M, Q92QKF