<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63P
Rx PI-naive
IncludeMixtures No
References 60
Patients 87
Isolates 87
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Op de Coul (2000)EO-CA20CA20AF247521None   L10V, T12A, I13V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69QF
Vergne (2000)95cm-mp25595CMMP255AJ249236None   T12A, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69Q, I93LF
 LVMP652LVMP652AJ286973None   L10I, E35D, M36I, R41K, K45R, I62V, L63P, H69Q, L89MF
 LVMP798LVMP798AJ286974None   I15V, K20R, E34K, E35D, M36I, P39Q, R41K, Q61E, L63P, H69Q, L89MF
Carr (2001)CM53657CM53657AF377956None   I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, L63P, H69Q, L89MF
Brindeiro (2003)BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRRJ916BRRJ916AY213270None   T12P, I15V, E35D, M36I, R57K, Q61D, L63P, C67S, Q92H, C95SF
Njouom (2003)27pol27polAY204311None   K14N, K20R, D25DH, L33V, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69QF
Eshleman (2004)ABB33ABB33AY444279None   I15V, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63P, H69Q, I72T, L89MF
 ABB51ABB51AY444280None   I15V, K20R, E35D, M36I, P39S, R41K, I62IV, L63P, H69HQ, L89MF
Kijak (2004)0016BBY02CM.0016AY371158None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63P, H69Q, L89MF
Konings (2004)KF_Pat1101CM5887AY359693None   L10V, I15V, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, L89MF
 KF_Pat1601CM5149AY359698None   L10I, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, V77I, L89MF
Machado (2004)N75N75AY569900None   E35D, M36I, R41K, R57K, D60E, Q61D, L63P, H69Y, I72T, V77IF
Rodrigues (2005)BLF_Pat26BR03SP138AY643161None   L10V, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, K70R, I72V, L89MF
Ndongmo (2006)CM72CBN_CM72DQ394167None   L10V, I13V, I15V, K20R, M36I, N37D, I62V, L63P, I72T, L89M, I93LF
Rodrigues (2006)BR04RS178BR04RS178DQ070591None   T12K, K14N, I15V, L19I, M36I, R57K, Q61N, L63PF
Santos (2006)021021PR_RTAY275729None   K14R, I15V, E35D, M36I, L38W, R41K, R57K, Q61N, I62V, L63P, C67Y, L89MF
 144144PR_RTAY275771None   E35D, N37D, R41K, I62V, L63P, V77I, L89M, I93LF
Vessiere (2006)AV_M4587NAV_M4587NDQ297200None  V32VAK14R, I15V, E35D, M36I, R41K, L63P, H69QF
Dilernia (2007)F006F006EF120077None   L10V, K14KR, I15V, M36I, R41K, K43R, Q61N, L63P, I72V, Q92TF
 F129F129EF120139None   T12TKPQ, K14R, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, I72V, L89MF
 F158F158EF120149None   T12P, K14R, E35D, M36I, R41K, K55F, R57K, Q61N, L63P, E65D, I72V, L89MF
 F299F299EF120218None   T12Q, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, I72T, I93LF
 F122F122EF120355None   I15V, E35D, R41K, R57K, Q61N, L63P, C67DEHQ, H69Y, V77I, L89LMF
Rios (2007)CH110MR_CH110EF194012None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, L89M, I93LF
Sucupira (2007)BRE_42_00BRE_42_00DQ902978None   E35D, M36I, R41K, R57K, D60E, Q61E, L63P, H69N, L89MF
 BRR_06_00BRR_06_00DQ902930None   N37D, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRE_19_99BRE_19_99DQ902958None   E35D, M36I, R41K, R57K, Q61D, L63P, T91AF
Vicenti (2007)498469246REF376527None   T12E, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, C67Y, L89MF
Ndembi (2008)CMYD-9204CMYD-92DQ990447None   I15V, E35D, M36I, P39Q, R41K, K45R, R57K, I62V, L63P, I72T, L89MF
Bartolo (2009)HM20001AOHM200EU068335None   T12S, I15V, K20R, M36I, R41K, R57K, I62V, L63P, H69Y, L89MF
Cardoso (2009)BRGO3043BRGO3043FJ548819None   T12P, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, E65D, C67W, T74TI, L89MF
 BRGO3140BRGO3140FJ594174None   I13V, I15V, K20M, E35D, M36I, N37K, P39T, R41K, K45R, R57K, D60E, Q61D, L63P, V82VI, L89MF
de Sa-Filho (2009)5538555385IthGQ294607None   T12N, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, V75VI, L89MF
 5591355913PgrGQ294622None   R41K, R57K, D60E, Q61N, L63P, G68E, L89MF
Dumans (2009)34_0534_05FJ405057None   L10V, I13V, G16E, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, I72TF
Vercauteren (2009)pt18991912045407GQ399125None   T12A, K14R, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, I72T, L89MF
 pt7528640409048GQ400272None   L10V, T12K, I15V, K20R, E35D, M36I, N37D, R41K, K43R, I62V, L63P, H69HQ, T74A, L89MF
Yebra (2009)SP90-387599SP90-387599EU545191None   K20R, E35D, M36I, N37D, R41K, K45R, R57RK, L63P, H69R, L89M, I93VF
Arruda (2010)100916CE081009JQ230576None   I15V, E35D, M36I, P39A, R41K, R57K, D60E, Q61D, L63P, I72VF
Djoko (2010)GQ09908GQ099FN557339None   I15V, K20R, E35D, M36I, N37E, R41K, K45KR, L63P, H69R, L89M, I93VF
Soares (2010)CM04_097CM04_097GU366147None   L10I, K20R, M36I, R57K, D60E, I62L, L63P, H69QF
Yebra (2010)40135107SP401351FJ481663None   T12I, I13V, I15V, E35D, R41K, R57K, Q61N, L63P, L89MF
Aghokeng (2011)HJ1783HJ1783JN639526None   L10V, T12TA, I15IV, L19LI, K20R, E35D, M36I, R41K, R57RK, L63P, H69QF
 SK1009-PISK1009-PIHQ864358None   L10V, I15V, K20R, E35D, M36I, R41K, K45R, D60E, I62V, L63P, H69Q, V82I, L89MF
Charpentier (2011)CR-54CR-54FJ688260None   K14R, I15V, E35D, M36I, R41K, I62V, L63P, I64M, H69Q, L89MF
Fokam (2011)CIRCB-10155CIRCB-10155JQ796127None   L10IV, K20R, E35D, M36I, R41K, D60E, I62V, L63P, I64IV, H69Q, I93LF
 CIRCB-10965CIRCB-10965JQ796130None   I15V, K20R, E35D, M36I, R41K, K45R, R57K, I62V, L63P, H69Q, L89MF
 CIRCB-11539CIRCB-11539JQ796136None   L10V, I15IV, K20R, E35D, M36I, N37NS, P39T, R41K, D60E, I62V, L63P, H69Q, G94VF
Sanabani (2011)BR2018BR2018JN692449None   T12E, K14E, I15V, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, E65R, T74S, L89MF
 BR1067BR1067JN692456None   I13V, M36I, R57K, Q61N, L63PF
Ajoge (2012)H32HP32HM854114None   L10V, K20R, L33V, E35D, M36I, D60E, I62V, L63P, H69QF
Betancor (2012)HCIII-00387599HCIII-00387599JX271326None   K20R, L33LV, E35D, M36I, N37D, R41K, K45R, R57RK, L63P, H69R, L89M, I93VF
da Silveira (2012)BRMS56BRMS56JF342306None   L10V, T12I, I13V, E35D, M36I, R41K, R57K, Q61D, L63P, L89MF
Karlsson (2012)SE_274SE_274JQ698858None   I15V, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, I72IVF
Oliveira (2012)05CVHAN305CVHAN3JF267447None   T12E, E35D, M36I, R57K, I62V, L63P, V77I, L89MF
Aghokeng (2013)HJ3026HJ3026JX982986None   L10V, T12N, I15V, K20R, E35D, M36I, R41RK, I62V, L63P, H69QF
Alencar (2013)RJ2-0022RJ2-0022JQ237949None   E35D, M36I, R41K, R57K, Q61N, L63P, I64L, H69Y, V77IF
 SP2-0026SP2-0026JQ238047None   L19Q, M36I, R41K, K45R, R57K, Q61D, L63P, L89IF
 PE2-0087PE2-0087JQ238226None   T12A, I13V, K14R, I15V, K20M, E35D, M36I, P39Q, R57K, D60E, Q61D, L63P, L89MF
Bila (2013)MZ10-159HIV-1KF927264None   I13IV, L19I, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, I93LF
Billong (2013)MR096MR096KF192238None  L33IVL10V, I15IV, K20R, E35D, M36I, R41K, K45KR, L63P, E65ED, L89MF
Ferreira (2013)BR09SP286BR09SP286HM534205None   I13V, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, L89MF
Temereanca (2013)SR43SR43JX966519None  Q58ET12S, K14T, I15V, K20R, E35D, M36I, P39S, R41K, R57K, I62K, L63P, E65D, H69R, I72T, L89M, Q92E, G94V, N98IF
Aghokeng (2014)CM-1-201CM-1-201KC350327None   L10V, T12I, I15V, K20R, E35D, M36I, R41K, R57RK, I62V, L63P, H69Q, L89MF
Agyingi (2014)LB089LB089KF576438None   T12S, I15V, K20R, E35D, M36I, N37D, R41K, K43R, I62V, L63P, H69Q, T74A, L89MF
Chikata (2014)KI-781KI-781AB874109None   L10V, I15V, E35D, M36I, R41K, K55KR, L63PF
Velasco-de-Castro (2014)05BRRJLTS14805BRRJLTS148KF922012None   T12P, K14R, R41K, R57K, Q61N, L63P, T74S, V77I, L89M, I93LF
 06BRRJRS10906BRRJRS109KF922131None   I15V, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, K70R, I72T, V77I, L89MF
 07BRRJRS7707BRRJRS77KF922171None   E35D, M36I, R41K, I62V, L63PF
Alexiev (2015)509_0707509_0707JQ259098None   Q18H, L19K, E21K, E35D, M36I, P39Q, R41K, R57K, Q61N, L63P, E65D, I72V, L89MF
Bruzzone (2015)NS0068FNS0068FEU914184None   I15V, Q18E, E35D, M36I, R41K, D60E, I62V, L63P, T74A, L89MF
de Lourdes Teixeira (2015)9RJ1102909RJ110290 None   K14R, I15V, G17E, K20KR, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, E65D, K70R, L89MF
 9RJ1200749RJ120074 None   L10I, L19IM, E35D, M36I, R41K, K43KR, R57K, Q61NS, L63P, H69Q, K70KR, L89MF
Guimaraes (2015)BRSP98-12BRSP98-12KP115517None   I15V, L19P, E35D, R41K, R57K, Q61N, L63P, H69Y, I72VF
Moura (2015)BRPI_83BRPI_83KF701009None   L19LI, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, I64M, C67SF
Pessoa (2015)10BR_RJ023RJ023KJ849797None   E35D, M36I, R41K, R57K, Q61N, L63P, I64L, H69Y, V77IF
Castley (2016)P149605128LP149605128LKT229110None   K14R, N37S, I62V, L63P, G68E, H69R, V77I, I93LF
Darcissac (2016)U14EZBGU14EZBGKT998194None   I15V, E35D, M36T, R41K, R57K, Q61N, L63PF
Delatorre (2016)13BRRJGN6413BRRJGN64KX357282None   I13V, I15V, L19M, E35D, M36I, R41K, R57K, D60E, Q61E, I62V, L63P, V77I, L89MF
Lima (2016)08PE04808PE048KX020962None   I15V, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, L89MF
 08PE06608PE066KX020983None   I15V, E35D, M36I, R41K, Q61N, L63P, I72T, L89MF
 03PE10303PE103KX020977None   T12P, K14R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, I72T, L89MF
 02PE04702PE047KX020961None   L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, L89MF
Lima (2016)BRGO6037BRGO6037KC249766None   T12S, I15V, E35D, M36I, R41K, D60DE, I62IV, L63P, V77IF
Pessoa (2016)10BR_SP02610BR_SP026KT427816None   L19Q, M36I, R41K, K45R, R57K, Q61D, L63P, L89IF