<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63P
Rx PI-naive
IncludeMixtures No
References 57
Patients 99
Isolates 99
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Tanuri (1999)BRAM-9BRAM-9AF076441None   M36I, N37D, R41X, R57K, Q61N, L63PF
Op de Coul (2000)EO-CA20CA20AF247521None   L10V, T12A, I13V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69QF
Vergne (2000)95cm-mp25595CMMP255AJ249236None   T12A, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69Q, I93LF
 LVMP652LVMP652AJ286973None   L10I, E35D, M36I, R41K, K45R, I62V, L63P, H69Q, L89MF
 LVMP798LVMP798AJ286974None   I15V, K20R, E34K, E35D, M36I, P39Q, R41K, Q61E, L63P, H69Q, L89MF
Carr (2001)CM53657CM53657AF377956None   I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, L63P, H69Q, L89MF
Kijak (2001)ARG-44ARG-44AF329587None   K14R, E35D, M36I, R41K, R57K, Q61N, I62IV, L63PF
Brindeiro (2003)BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRSP544BRSP544AY213221None   I15V, E35D, M36I, R41K, R57K, I62V, L63P, K70R, V77VI, I93LF
Njouom (2003)27pol27polAY204311None   K14N, K20R, D25DH, L33V, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69QF
Soares (2003)BRRJ860BRRJ860AF527352None   L10I, I15V, E35D, M36I, R41K, L63P, E65D, I72V, C95SF
Eshleman (2004)ABB33ABB33AY444279None   I15V, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63P, H69Q, I72T, L89MF
 ABB51ABB51AY444280None   I15V, K20R, E35D, M36I, P39S, R41K, I62IV, L63P, H69HQ, L89MF
Espinosa (2004)11AY140108None   I15A, K20M, E35D, M36I, R41K, R57K, Q61D, L63P, I93LF
Kijak (2004)0016BBY02CM.0016AY371158None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63P, H69Q, L89MF
 0908MO01CM.0908AY371170None   I13V, E35D, M36I, L63P, H69QF
Konings (2004)KF_Pat1101CM5887AY359693None   L10V, I15V, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, L89MF
 KF_Pat1601CM5149AY359698None   L10I, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, V77I, L89MF
Machado (2004)N33N33AY569869None   L10I, E35D, M36I, N37D, R41K, D60E, Q61N, L63P, K70R, I72TF
 N75N75AY569900None   E35D, M36I, R41K, R57K, D60E, Q61D, L63P, H69Y, I72T, V77IF
Rodrigues (2005)BLF_Pat26BR03SP138AY643161None   L10V, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, K70R, I72V, L89MF
Ndongmo (2006)CM72CBN_CM72DQ394167None   L10V, I13V, I15V, K20R, M36I, N37D, I62V, L63P, I72T, L89M, I93LF
Petroni (2006)AP_ARRP001AP_ARRP001DQ206645None   T12N, I15V, L19T, K20R, M36I, N37D, R41K, R57K, D60E, Q61N, I62V, L63P, P79S, I93LF
 AP_ARRP017AP_ARRP017DQ206654None   N37E, L63P, I64LF
 AP_ARRP050AP_ARRP050DQ345500None   I15V, E35D, M36I, R41K, R57K, Q61N, L63P, I93LF
 AP_ARRP054AP_ARRP054DQ345503None   I15V, G17D, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, V77I, I93LF
 AP_ARRP057AP_ARRP057DQ345504None   T12E, L19I, E35D, M36I, R41K, D60E, I62V, L63P, C67CYF
Rodrigues (2006)BR04RS178BR04RS178DQ070591None   T12K, K14N, I15V, L19I, M36I, R57K, Q61N, L63PF
Santos (2006)021021PR_RTAY275729None   K14R, I15V, E35D, M36I, L38W, R41K, R57K, Q61N, I62V, L63P, C67Y, L89MF
 144144PR_RTAY275771None   E35D, N37D, R41K, I62V, L63P, V77I, L89M, I93LF
 149PR149PRAY275786None   E35D, M36I, N37E, R41K, R57K, D60E, Q61N, L63P, E65DF
Vessiere (2006)AV_M4587NAV_M4587NDQ297200None  V32VAK14R, I15V, E35D, M36I, R41K, L63P, H69QF
Dilernia (2007)F006F006EF120077None   L10V, K14KR, I15V, M36I, R41K, K43R, Q61N, L63P, I72V, Q92TF
 F018F018EF120082None   T12P, I13V, I15V, E35D, R41K, R57K, Q61N, L63P, I93LF
 F129F129EF120139None   T12TKPQ, K14R, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, I72V, L89MF
 F158F158EF120149None   T12P, K14R, E35D, M36I, R41K, K55F, R57K, Q61N, L63P, E65D, I72V, L89MF
 F182F182EF120161None   I15V, E35D, M36I, R41K, R57K, Q61N, L63P, K70KR, I72V, I93LF
 F187F187EF120163None   T12S, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, I93LF
 F189F189EF120164None   L10V, T12N, I15V, E35D, M36I, N37D, P39Q, R41K, K45R, R57K, D60E, Q61D, L63P, K70M, I72R, I93LF
 F213F213EF120177None   L10I, T12I, I13V, I15V, K20R, M36I, R41K, R57K, Q61N, L63P, I93LF
 F214F214EF120178None   K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, H69CF
 F297F297EF120216None   I15V, E35D, M36I, R41K, R57K, Q61D, L63P, I64L, H69HY, I93LF
 F299F299EF120218None   T12Q, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, I72T, I93LF
 F328F328EF120233None   I15V, G16E, K20R, E35D, R41K, R57K, Q61N, L63P, I93LF
 F122F122EF120355None   I15V, E35D, R41K, R57K, Q61N, L63P, C67DEHQ, H69Y, V77I, L89LMF
Eyer-Silva (2007)BRSQ4604BRSQ46EF042651None   T12K, I15V, E35D, M36I, R41K, R57K, Q61E, L63P, E65DF
Gonsalez (2007)27HIV_27GU288772None   E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I93LF
Rios (2007)CH110MR_CH110EF194012None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, L89M, I93LF
Vicenti (2007)498469246REF376527None   T12E, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, C67Y, L89MF
von Wyl (2007)1001313047EF449815None   I13V, K20I, M36I, N37N_N, L63P, H69K, K70R, V77I, L89MF
Ferreira (2008)623BR06PR623EU340743None   L10V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61N, L63P, I72E, I93LF
Ibe (2008)210210AB356241None   I13V, G17E, M36I, R41K, R57K, D60E, Q61D, L63PF
Ndembi (2008)CMYD-9204CMYD-92DQ990447None   I15V, E35D, M36I, P39Q, R41K, K45R, R57K, I62V, L63P, I72T, L89MF
Palacios (2008)1264012640 None   I15V, E35ED, M36I, R41K, R57K, Q61D, I62IV, L63P, I64L, I72T, V82I, I93LF
Bartolo (2009)HM20001AOHM200EU068335None   T12S, I15V, K20R, M36I, R41K, R57K, I62V, L63P, H69Y, L89MF
Cardoso (2009)BRGO3043BRGO3043FJ548819None   T12P, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, E65D, C67W, T74TI, L89MF
 BRGO3140BRGO3140FJ594174None   I13V, I15V, K20M, E35D, M36I, N37K, P39T, R41K, K45R, R57K, D60E, Q61D, L63P, V82VI, L89MF
de Sa-Filho (2009)5538555385IthGQ294607None   T12N, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, E65D, V75VI, L89MF
 5591355913PgrGQ294622None   R41K, R57K, D60E, Q61N, L63P, G68E, L89MF
Dumans (2009)34_0534_05FJ405057None   L10V, I13V, G16E, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, I72TF
Vercauteren (2009)pt2051998007143GQ398973None   I15V, K20MR, E35D, M36I, N37D, R41K, R57K, L63P, Q92KF
 pt18991912045407GQ399125None   T12A, K14R, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, I72T, L89MF
 pt7528640409048GQ400272None   L10V, T12K, I15V, K20R, E35D, M36I, N37D, R41K, K43R, I62V, L63P, H69HQ, T74A, L89MF
Yebra (2009)SP90-387599SP90-387599EU545191None   K20R, E35D, M36I, N37D, R41K, K45R, R57RK, L63P, H69R, L89M, I93VF
Arruda (2010)100916CE081009JQ230576None   I15V, E35D, M36I, P39A, R41K, R57K, D60E, Q61D, L63P, I72VF
 108316CE091083JQ230674None   T12A, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I64ILF
Djoko (2010)GQ09908GQ099FN557339None   I15V, K20R, E35D, M36I, N37E, R41K, K45KR, L63P, H69R, L89M, I93VF
Ferreira (2010)p053Dip053GQ862341None   L10I, K14R, I15V, E35D, M36I, R41K, L63P, H69Q, K70T, I93LF
Soares (2010)CM04_097CM04_097GU366147None   L10I, K20R, M36I, R57K, D60E, I62L, L63P, H69QF
Yebra (2010)40135107SP401351FJ481663None   T12I, I13V, I15V, E35D, R41K, R57K, Q61N, L63P, L89MF
Aghokeng (2011)HJ1783HJ1783JN639526None   L10V, T12TA, I15IV, L19LI, K20R, E35D, M36I, R41K, R57RK, L63P, H69QF
 SK1009-PISK1009-PIHQ864358None   L10V, I15V, K20R, E35D, M36I, R41K, K45R, D60E, I62V, L63P, H69Q, V82I, L89MF
Aulicino (2011)3064-F893064-F89HQ158255None   I15V, G16E, K20M, E35D, M36I, P39T, R41K, R57K, Q61N, L63P, I93LF
 94-66194-661HQ158265None   T12A, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, V77I, I93LF
Charpentier (2011)CR-54CR-54FJ688260None   K14R, I15V, E35D, M36I, R41K, I62V, L63P, I64M, H69Q, L89MF
Fokam (2011)CIRCB-10155CIRCB-10155JQ796127None   L10IV, K20R, E35D, M36I, R41K, D60E, I62V, L63P, I64IV, H69Q, I93LF
 CIRCB-10965CIRCB-10965JQ796130None   I15V, K20R, E35D, M36I, R41K, K45R, R57K, I62V, L63P, H69Q, L89MF
 CIRCB-11539CIRCB-11539JQ796136None   L10V, I15IV, K20R, E35D, M36I, N37NS, P39T, R41K, D60E, I62V, L63P, H69Q, G94VF
Hamers (2011)300117CP076300117HM119694None   E35D, M36I, R41K, L63P, H69K, I93LF
 300679CP076300679HM120068None   T12S, I15V, L19I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, T74TA, I93LF
Sanabani (2011)BR2018BR2018JN692449None   T12E, K14E, I15V, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, E65R, T74S, L89MF
Ajoge (2012)H32HP32HM854114None   L10V, K20R, L33V, E35D, M36I, D60E, I62V, L63P, H69QF
Chen (2012)YN09DH0033YN09DH0033JQ658503None   T12S, K14R, I15V, L19I, M36I, R41K, L63P, H69K, K70R, I93LF
da Silveira (2012)BRMS56BRMS56JF342306None   L10V, T12I, I13V, E35D, M36I, R41K, R57K, Q61D, L63P, L89MF
Karlsson (2012)SE_274SE_274JQ698858None   I15V, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, I72IVF
Aghokeng (2013)HJ3026HJ3026JX982986None   L10V, T12N, I15V, K20R, E35D, M36I, R41RK, I62V, L63P, H69QF
Alencar (2013)SP2-0026SP2-0026JQ238047None   L19Q, M36I, R41K, K45R, R57K, Q61D, L63P, L89IF
 PE2-0087PE2-0087JQ238226None   T12A, I13V, K14R, I15V, K20M, E35D, M36I, P39Q, R57K, D60E, Q61D, L63P, L89MF
Billong (2013)MR091MR091KF192255None   L10I, I15V, Q18K, E35D, M36I, N37DE, R41K, W42WL, R57K, Q61QP, L63P, C67Y, H69Q, K70RF
 MR096MR096KF192238None  L33IVL10V, I15IV, K20R, E35D, M36I, R41K, K45KR, L63P, E65ED, L89MF
Ferreira (2013)BR09SP211BR09SP211HM534126None   E35D, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, I93LF
 BR09SP286BR09SP286HM534205None   I13V, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, L89MF
Temereanca (2013)SR43SR43JX966519None  Q58ET12S, K14T, I15V, K20R, E35D, M36I, P39S, R41K, R57K, I62K, L63P, E65D, H69R, I72T, L89M, Q92E, G94V, N98IF
Thiam (2013)2579-HALD2579-HALDJN673584None   T12A, L19T, R41K, L63P, H69Q, I93LF
Steegen (2014)09ZAKS02109ZAKS021KJ176303None   R41K, R57K, D60E, L63P, C67Y, H69KF
 12ZAKS20612ZAKS206KJ176486None   R41K, L63P, H69K, I93LF
 11ZAKS09911ZAKS099KJ176381None   R41K, L63P, H69K, I93LF
 12ZAKS24812ZAKS248KJ176527None   R41K, D60E, L63P, H69K, K70T, I93LF
 11ZAKS10411ZAKS104KJ176386None   R41K, L63P, H69K, I93LF