<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63C
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 63
Isolates 64
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-231CB-231AF252092SQV, IDV G48V, I54V, V82A L10I, T12N, I15V, K20R, E35D, M36I, R41K, K43I, R57K, Q61N, L63CF
Dumans (2004)RG018RG018AY390205RTV, SQV, IDV, NFV, Unknown>252V82VA L10I, T12N, I15V, K20R, E35D, M36I, N37T, R41K, K45R, I54X, R57K, Q61N, I62V, L63C, A71AV, T74S, L89IM, I93LF
Gomez-Carrillo (2004)100502100502AY365613PINAI54V, V82A, L90M L10I, I15V, G17D, K20KR, E35D, M36I, R41K, K45R, R57K, Q61D, L63C, L89MF
 105322105322AY365723PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72VF
 105436105436AY365727PINAM46L, I54V, L76V, V82AL23LIL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89MF
 122494122494AY366012PINAM46I, I54V, V82AL24I, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61N, L63C, L89LMF
Montes (2004)MB_patBAR99_BAR710AJ577733RTV, SQV, NFV176V82A K14Q, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, L89MF
  01_BAR714AJ577734RTV, SQV, NFV, APV, LPV273V82A L10I, K14Q, I15V, K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, L63C, E65D, T74S, L89MF
Rodrigues (2005)BLF_Pat28BR02SP258AY643148NFV71M46ML, N88NS, L90LM G17E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, L89MF
Baxter (2006)12-13091309-30505DQ876224PINAG48V, I54V, L90MK43TL10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, I62V, L63C, I93LF
 48-11621162-30814DQ877267PINAM46L, I54V, L76V, V82AL23IL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89MF
 48-10721072-30625DQ877333PINAM46I, I54V, V82AL24I, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61D, L63CF
 48-11391139-30814DQ877399PINAM46L, G48V, I54T, V82AL24IL10I, K20R, E35D, M36I, N37DE, R41K, K43R, R57K, Q61N, L63C, T74S, L89MF
 48-91109110-30917DQ877697PINAI54A, V82A L10I, T12TN, I15V, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, I62V, L63C, A71V, T74S, L89LI, I93LF
Waleria-Aleixo (2008)08PR05032708PR050327FJ591355PINA  L10I, T12N, E35D, M36I, R41K, R57K, Q61N, L63C, I64L, L89M, I93LF
 08PR06054908PR060549FJ591464PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63C, A71AT, T74S, Q92KF
Dumans (2009)RENA686RENA686FJ405043IDV, NFV326M46I, I54V, V82AL24I, K43T, T74PL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63C, E65D, L89MF
 RENA140RENA140FJ405170NFV91D30NN88DL10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61D, L63C, K70R, I72T, L89MF
 RENA430RENA430FJ405180Unknown, NFV>83  I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63CF
Aulicino (2012)BO02BOL119BOL119EU581827PINA  I15V, G16E, E35D, M36I, P39S, R41K, K43R, R57K, Q61N, L63CF
Jones (2012)162512162512JN670040PINAM46I, I54V, V82S, I84V L10LV, I15V, G16E, K20R, E34A, E35D, M36I, R41K, K43I, K55R, R57K, D60DN, Q61DN, L63C, L89LMF
 173048173048JN670311PINA  I15V, G17D, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72IV, L89MF
 183721183721JN670658PINAL90M I13IV, I15V, G16GE, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, T74S, L89LIMF
 195817195817JN671002PINAI54V, V82AL24I, L33F, K43T, N83DL10I, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63C, L89IF
 201750201750JN671235PINA  I13V, E35D, M36I, R41K, K43R, R57K, D60E, Q61D, I62V, L63C, T91VF
 204749204749JN671349PINA  L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, L63C, E65D, K70KR, I72TF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF
 207065207065JN671420PINA  I13V, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, L63C, I72T, L89LMF
Diaz (2015)RenG16988RenG16988KT748016PINAM46I, I50L, V82CFLR, L90MF53LL10I, I13L, K20I, E34Q, E35D, M36I, N37T, R41K, K55KN, R57K, Q61N, L63C, I64L, A71V, I72T, T74S, L89M, I93LF
 RenG16403RenG16403KT747431PINA  I15V, G16E, E35D, M36I, R41K, R57RK, Q61N, L63C, E65D, I72TF
 RenG17405RenG17405KT748433PINA  L10I, I15V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, L63C, V77I, L89M, I93LF
 RenG16609RenG16609KT747637PINAM46I, I50V, I54V, V82AL24LI, L76ML10V, I15V, K20R, E35D, M36I, R41K, K45KR, K55R, R57K, Q61N, L63C, T74S, L89MF
 RenG15748RenG15748KT746776PINA  T12M, I15V, Q18E, E35D, M36I, R41K, R57K, Q61N, L63C, I72TF
 RenG16376RenG16376KT747404PINA  I15V, Q18E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, I72ITF
 RenG16653RenG16653KT747681PINAV82A, L90M L10I, I15V, G16GE, K20MR, E35D, M36I, N37NDEK, R41K, R57K, Q61N, L63C, I72ITF
 RenG15692RenG15692KT746720PINAI50L, V82ML33LF, F53LK20T, E35D, M36I, N37NT, P39S, R41K, R57K, D60E, Q61DN, L63C, I72V, T74TA, V77I, L89MF
 RenG16448RenG16448KT747476PINA  T12A, E35D, M36I, R57K, Q61N, L63C, I72T, L89MF
 RenG16239RenG16239KT747267PINAM46MI, I50IV L10I, T12TI, I13V, I15V, G16E, E35D, M36I, N37NT, P39K, R41K, R57K, Q61N, L63C, L89MF
 RenG16638RenG16638KT747666PINAM46I, I50V, I54V, V82AK43TW6L, Q7A, L10V, D25Y, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG16948RenG16948KT747976PINAM46I, I50V, I54V, V82AK43TL10V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG16703RenG16703KT747731PINA  E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG15111RenG15111KT746139PINA  L10I, I15IV, E35D, M36I, R41K, R57K, D60E, Q61D, L63C, L89M, I93LF
 RenG13800RenG13800KT744828PINAM46IL10F, V32AI13V, I15V, K20T, E35D, M36I, N37NKT, R41K, K55N, R57K, Q61N, L63C, I64V, E65D, V77I, L89MF
 RenG14674RenG14674KT745702PINA  T12N, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63C, E65D, I72TF
 RenG14329RenG14329KT745357PINA  T12M, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG14759RenG14759KT745787PINA  I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61K, L63C, E65D, V82VIF
 RenG15329RenG15329KT746357PINAL90LM I15V, G16E, K20T, E35DG, M36I, P39S, R41K, K45R, R57K, Q61D, L63C, I72V, T74S, L89MF
 RenG14468RenG14468KT745496PINA  T12TS, I15V, E35D, M36I, R41K, Q61N, L63C, L89MF
 RenG14122RenG14122KT745150PINA  K14R, I15V, E35D, M36I, N37NS, P39S, R41K, R57K, Q61N, L63C, K70R, I72V, L89MF
 RenG15472RenG15472KT746500PINA  T12N, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61D, L63C, E65D, I72TF
 RenG14222RenG14222KT745250PINAI54V, V82F, L90MQ58EL10I, I15L, G16A, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63C, A71V, I72T, V77I, L89M, I93LF
 RenG12314RenG12314KT743342PINAD30N, I54LL33F, Q58QE, N88DR8P, L10V, I13V, I15V, K20T, T31A, E35D, M36I, K43R, R57K, Q61N, L63C, T74S, L89IMF
 RenG13500RenG13500KT744528PINA  I15V, G17E, K20R, E35D, M36I, R41K, R57K, D60DE, Q61D, L63C, I72IV, L89MF
 RenG13406RenG13406KT744434PINA  L10V, I15V, G16GE, K20R, T31S, E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG12301RenG12301KT743329PINAD30N, I50LN88DT12N, I15V, L19I, K20T, E35D, M36I, N37T, R41K, K45R, Q61D, L63C, E65D, A71LV, V77IF
 RenG12504RenG12504KT743532PINAI50L T12I, G17E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, I64V, V82I, L89MF
 RenG12636RenG12636KT743664PINAD30N, V32VI, M46I, I47V, I54LVF53FL, L76LM, N88DL10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92RF
 RenG12955RenG12955KT743983PINA  L10V, I15V, E35D, M36I, R41K, R57K, D60N, Q61D, L63C, T74S, L89M, I93LF
 RenG13021RenG13021KT744049PINAN88SF53L, Q58EL10I, G16E, K20T, E35D, M36V, N37H, P39S, R41K, R57K, D60E, Q61D, L63C, A71V, V77IL, L89M, I93LF
 RenG12096RenG12096KT743124PINAI50L, V82ML33LF, F53LT12TM, G16E, K20T, E35DN, M36I, N37NT, P39S, R41K, R57K, D60E, Q61DN, L63C, I72V, T74TA, V77I, L89MF
 RenG11279RenG11279KT742307PINAG48V, I54V, L76V, V82A, I84VM46V, Q58EL10I, I15V, G16E, K20R, E35D, M36I, K55R, R57K, Q61N, L63C, L89IF
 RenG10244RenG10244KT741272PINA  T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, V82VIF
 RenG10711RenG10711KT741739PINA  T12N, I15V, L19V, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, K70R, I72TF
 RenG10251RenG10251KT741279PINAD30N, I50L, V82AL33LF, M46MV, N88DL10V, T12I, I13V, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63C, I64L, A71V, I72L, L89IT, I93LF