<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63C
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 113
Isolates 114
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-231CB-231AF252092SQV, IDV G48V, I54V, V82A L10I, T12N, I15V, K20R, E35D, M36I, R41K, K43I, R57K, Q61N, L63CF
Dumans (2004)RG018RG018AY390205RTV, SQV, IDV, NFV, Unknown>252V82VA L10I, T12N, I15V, K20R, E35D, M36I, N37T, R41K, K45R, I54X, R57K, Q61N, I62V, L63C, A71AV, T74S, L89IM, I93LF
Gomez-Carrillo (2004)9711397113AY365541PINAM46ML, G48GV, I54IV Q7QH, L10LI, T12TN, I15V, L19I, K20KR, E35D, M36I, R41K, R57K, Q61N, I62IV, L63C, T74TS, I93LF
 9963399633AY365600PINAM46I, I54V, V82A L10V, I15V, K20R, E35D, M36I, N37T, R41K, K55R, R57K, D60E, Q61N, L63C, T74SF
 100502100502AY365613PINAI54V, V82A, L90M L10I, I15V, G17D, K20KR, E35D, M36I, R41K, K45R, R57K, Q61D, L63C, L89MF
 105322105322AY365723PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72VF
 105436105436AY365727PINAM46L, I54V, L76V, V82AL23LIL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89MF
 105677105677AY365732PINAI54A, V82A L10I, I15V, K20R, E35D, M36I, N37D, R41K, F53I, R57K, D60E, Q61D, I62V, L63C, I66IL, A71V, I93LF
 106003106003AY365742PINA  L10LI, T12TA, K14R, I15V, G17E, M36I, R41K, R57K, Q61N, L63C, I93LF
 109303109303AY365813PINA  K14T, I15V, G16GE, K20KR, E35D, M36I, R41K, K45R, R57K, Q61N, L63CF
 112892112892AY365865PINAV82A L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72T, T74SF
 122494122494AY366012PINAM46I, I54V, V82AL24I, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61N, L63C, L89LMF
 126215126215AY366053PINA  I15V, G16E, E35D, M36I, P39T, R41K, R57K, Q61N, L63C, E65DF
Montes (2004)MB_patBAR99_BAR710AJ577733RTV, SQV, NFV176V82A K14Q, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, L89MF
  01_BAR714AJ577734RTV, SQV, NFV, APV, LPV273V82A L10I, K14Q, I15V, K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, L63C, E65D, T74S, L89MF
Rodrigues (2005)BLF_Pat28BR02SP258AY643148NFV71M46ML, N88NS, L90LM G17E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, L89MF
Baxter (2006)48-11741174-30915DQ877358PINAM46L, I54V, V82A L10V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, G68E, A71V, I93LF
 48-11761176-30901DQ877425PINAM46L, G48V, I54V, V82S L10IV, T12TN, I15IV, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, I72V, T74S, I93LF
 48-91109110-30917DQ877697PINAI54A, V82A L10I, T12TN, I15V, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, I62V, L63C, A71V, T74S, L89LI, I93LF
Dumans (2009)RENA686RENA686FJ405043IDV, NFV326M46I, I54V, V82AL24I, K43T, T74PL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63C, E65D, L89MF
 RENA140RENA140FJ405170NFV91D30NN88DL10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61D, L63C, K70R, I72T, L89MF
 RENA430RENA430FJ405180Unknown, NFV>83  I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63CF
Aulicino (2011)ARN16ATJARN16ATJFJ525848PINA  K14R, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63C, H69Y, I72TF
 4202-I8974202-I897HQ158259PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63CF
Jones (2012)130379130379JN669485PINAM46L, G48V, I54V, V82S L10I, T12N, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, A71AV, I72IV, T74TS, I93LF
 137286137286JN669562PINA  L10I, E35D, M36I, R41K, R57K, Q61N, L63C, I93LF
 138214138214JN669570PINA  L10I, K14R, I15V, E35D, M36I, N37D, R41K, R57K, Q61N, L63C, H69HY, I72T, I93LF
 142772142772JN669625PINAI54V, V82S L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, H69Y, A71V, I72T, T74S, I93LF
 145210145210JN669654PINA  I13IV, G16GE, E35ED, M36I, R41K, R57RK, D60DE, Q61N, I62IV, L63C, I64IL, E65ED, V77VIF
 150685150685JN669753PINAM46I, I54LV, V82C, L90MG73TL10IV, I13M, I15V, G16E, K20V, E35NS, M36I, R41K, K55KR, R57K, Q61N, I62V, L63C, A71T, I72T, I93LF
 151921151921JN669772PINA V11VIL10I, T12E, K14R, I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, I62V, L63C, I93LF
 152725152725JN669784PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, I93LF
 157978157978JN669905PINAI54V, V82AK43TL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, I64L, L89M, I93LF
 158437158437JN669919PINA  I15V, E35D, M36I, N37ND, R41K, R57K, D60E, Q61N, L63C, I93ILF
 159510159510JN669955PINAI54V, V82A, L90MK43TL10I, I15V, G16E, K20M, E35D, M36I, R41R_R, R57K, Q61N, I62L, L63C, A71T, I72T, T74S, I85VF
 161428161428JN670007PINAM46L, I54V, V82AL24LI, L33LF, K43KTL10V, T12K, K14I, I15V, G16E, L19P, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, L63C, E65D, A71AV, L89M, Q92K, I93ILF
 161762161762JN670015PINA  T12I, I15V, G16E, E35D, M36I, R41K, R57K, Q61DN, L63C, I72TF
 162071162071JN670027PINAD30N I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63C, A71AT, I72T, L89LPF
 162512162512JN670040PINAM46I, I54V, V82S, I84V L10LV, I15V, G16E, K20R, E34A, E35D, M36I, R41K, K43I, K55R, R57K, D60DN, Q61DN, L63C, L89LMF
 162645162645JN670045PINAI54V, V82A, I84V, L90ML23I, Q58EL10I, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63C, I64V, A71V, V77I, I93LF
 166496166496JN670132PINA  I3IV, T4TS, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, L63C, H69QF
 167151167151JN670145PINAI54L, L90M L10V, I15V, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63C, E65D, I72T, V77I, I93LF
 167755167755JN670160PINA  L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61D, L63C, E65D, I72T, T91TI, I93L, T96TAF
 167839167839JN670166PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I93LF
 169081169081JN670190PINAM46L, G48V, I54V, V82S, I84V L10V, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, A71V, I72V, T74S, I93LF
 169590169590JN670201PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65ED, T74SF
 169773169773JN670211PINA  L10V, T12A, K14R, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63C, I72TF
 170678170678JN670230PINA  I15V, L19Q, E35D, M36I, R41K, Q61N, L63C, E65D, I93LF
 172538172538JN670292PINA  I15V, G16E, E35D, M36I, P39T, R41K, R57K, Q61N, L63C, E65DF
 172596172596JN670293PINA  I15V, E35D, M36I, N37D, R57K, Q61D, L63C, T74S, I93LF
 173048173048JN670311PINA  I15V, G17D, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72IV, L89MF
 173204173204JN670315PINAM46I, I54IL, V82C, L90MG73TL10V, I13M, I15V, G16E, K20V, E35NS, M36I, R41K, K55R, R57K, Q61N, I62V, L63C, A71T, I72T, I93LF
 173393173393JN670327PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, I72TF
 173668173668JN670341PINA  I15V, K20KR, E35D, M36I, R41K, R57K, Q61N, L63C, I72T, V82I, I93LF
 175825175825JN670375PINAI50V, I54V, V82A W6S, L10V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, K45I, R57K, Q61N, L63C, A71V, I72T, I93LF
 175988175988JN670383PINAI50V, I54V, V82A W6S, L10V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, K45I, R57K, Q61N, L63C, A71V, I72T, I93LF
 179874179874JN670530PINA  L10V, T12I, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63C, H69C, I72TF
 179961179961JN670533PINAI54L, L90M I15V, G16GE, K20T, E35D, M36I, R41K, R57K, Q61N, I62IV, L63C, T74S, I93LF
 180523180523JN670548PINA  K14R, I15V, E35D, M36I, P39S, R41K, R57K, Q61N, L63CF
 181255181255JN670570PINA  E35D, M36I, R41K, R57K, Q61N, L63CF
 183721183721JN670658PINAL90M I13IV, I15V, G16GE, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, T74S, L89LIMF
 183976183976JN670667PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, T74S, I93LF
 191533191533JN670830PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65D, I72IT, I93LF
 191895191895JN670839PINA  T4TP, I15V, E35D, M36I, R41K, Q61N, L63CF
 192047192047JN670844PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, G16E, K20R, E35D, M36I, R41RK, K55R, R57K, D60E, Q61N, I62IV, L63C, E65ED, L89MF
 192932192932JN670875PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61D, L63C, E65D, I93LF
 194388194388JN670932PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, I93LF
 194454194454JN670935PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65DF
 195388195388JN670978PINA  L10V, I15V, E35D, M36I, N37NDEK, R41K, R57RK, Q61N, L63C, E65D, I72IT, I93LF
 195588195588JN670986PINAL90M L10I, G17DE, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, E65D, T74S, I93LF
 197012197012JN671054PINA  I15V, E35D, M36I, P39T, R41K, R57K, Q61N, L63C, E65DF
 197469197469JN671073PINAM46L, I54V, V82A, L90M L5LI, W6LS, Q7QH, L10V, I15V, G16E, L19V, K20R, E35D, M36I, P39S, R41K, K55R, R57K, Q61N, L63C, E65ED, A71V, I72V, I93LF
 202168202168JN671258PINAI54V, V82S L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, H69Y, A71V, I72T, T74S, I93LF
 204007204007JN671326PINA  T12M, I15V, E35D, M36I, R41K, G51A, Q61D, L63CF
 204749204749JN671349PINA  L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, L63C, E65D, K70KR, I72TF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF
Diaz (2015)RenG16988RenG16988KT748016PINAM46I, I50L, V82CFLR, L90MF53LL10I, I13L, K20I, E34Q, E35D, M36I, N37T, R41K, K55KN, R57K, Q61N, L63C, I64L, A71V, I72T, T74S, L89M, I93LF
 RenG16403RenG16403KT747431PINA  I15V, G16E, E35D, M36I, R41K, R57RK, Q61N, L63C, E65D, I72TF
 RenG17405RenG17405KT748433PINA  L10I, I15V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, L63C, V77I, L89M, I93LF
 RenG16609RenG16609KT747637PINAM46I, I50V, I54V, V82AL24LI, L76ML10V, I15V, K20R, E35D, M36I, R41K, K45KR, K55R, R57K, Q61N, L63C, T74S, L89MF
 RenG15748RenG15748KT746776PINA  T12M, I15V, Q18E, E35D, M36I, R41K, R57K, Q61N, L63C, I72TF
 RenG17182RenG17182KT748210PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63C, E65DF
 RenG16376RenG16376KT747404PINA  I15V, Q18E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, I72ITF
 RenG16653RenG16653KT747681PINAV82A, L90M L10I, I15V, G16GE, K20MR, E35D, M36I, N37NDEK, R41K, R57K, Q61N, L63C, I72ITF
 RenG16448RenG16448KT747476PINA  T12A, E35D, M36I, R57K, Q61N, L63C, I72T, L89MF
 RenG16239RenG16239KT747267PINAM46MI, I50IV L10I, T12TI, I13V, I15V, G16E, E35D, M36I, N37NT, P39K, R41K, R57K, Q61N, L63C, L89MF
 RenG16638RenG16638KT747666PINAM46I, I50V, I54V, V82AK43TW6L, Q7A, L10V, D25Y, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG16948RenG16948KT747976PINAM46I, I50V, I54V, V82AK43TL10V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63C, A71V, I72V, T74S, L89M, I93LF
 RenG16703RenG16703KT747731PINA  E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG15111RenG15111KT746139PINA  L10I, I15IV, E35D, M36I, R41K, R57K, D60E, Q61D, L63C, L89M, I93LF
 RenG14674RenG14674KT745702PINA  T12N, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63C, E65D, I72TF
 RenG14329RenG14329KT745357PINA  T12M, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG14759RenG14759KT745787PINA  I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61K, L63C, E65D, V82VIF
 RenG13626RenG13626KT744654PINA  L10V, T12N, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, V77VI, I93LF
 RenG13866RenG13866KT744894PINA  L10I, T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, I93LF
 RenG15329RenG15329KT746357PINAL90LM I15V, G16E, K20T, E35DG, M36I, P39S, R41K, K45R, R57K, Q61D, L63C, I72V, T74S, L89MF
 RenG14468RenG14468KT745496PINA  T12TS, I15V, E35D, M36I, R41K, Q61N, L63C, L89MF
 RenG14122RenG14122KT745150PINA  K14R, I15V, E35D, M36I, N37NS, P39S, R41K, R57K, Q61N, L63C, K70R, I72V, L89MF
 RenG14063RenG14063KT745091PINA T74TPT12E, K14KQR, I15V, K20R, E35D, M36I, N37NS, R41K, R57K, Q61N, I62V, L63C, I93LF
 RenG15472RenG15472KT746500PINA  T12N, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61D, L63C, E65D, I72TF
 RenG14222RenG14222KT745250PINAI54V, V82F, L90MQ58EL10I, I15L, G16A, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63C, A71V, I72T, V77I, L89M, I93LF
 RenG12314RenG12314KT743342PINAD30N, I54LL33F, Q58QE, N88DR8P, L10V, I13V, I15V, K20T, T31A, E35D, M36I, K43R, R57K, Q61N, L63C, T74S, L89IMF
 RenG13500RenG13500KT744528PINA  I15V, G17E, K20R, E35D, M36I, R41K, R57K, D60DE, Q61D, L63C, I72IV, L89MF
 RenG13406RenG13406KT744434PINA  L10V, I15V, G16GE, K20R, T31S, E35D, M36I, R41K, R57K, Q61N, L63C, L89MF
 RenG12301RenG12301KT743329PINAD30N, I50LN88DT12N, I15V, L19I, K20T, E35D, M36I, N37T, R41K, K45R, Q61D, L63C, E65D, A71LV, V77IF
 RenG12955RenG12955KT743983PINA  L10V, I15V, E35D, M36I, R41K, R57K, D60N, Q61D, L63C, T74S, L89M, I93LF
 RenG13021RenG13021KT744049PINAN88SF53L, Q58EL10I, G16E, K20T, E35D, M36V, N37H, P39S, R41K, R57K, D60E, Q61D, L63C, A71V, V77IL, L89M, I93LF
 RenG12096RenG12096KT743124PINAI50L, V82ML33LF, F53LT12TM, G16E, K20T, E35DN, M36I, N37NT, P39S, R41K, R57K, D60E, Q61DN, L63C, I72V, T74TA, V77I, L89MF
 RenG11279RenG11279KT742307PINAG48V, I54V, L76V, V82A, I84VM46V, Q58EL10I, I15V, G16E, K20R, E35D, M36I, K55R, R57K, Q61N, L63C, L89IF
 RenG10927RenG10927KT741955PINA  L10V, T12N, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63C, K70KR, I72TF
 RenG10244RenG10244KT741272PINA  T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, V82VIF
 RenG11360RenG11360KT742388PINA  I15V, E35D, M36I, R41K, K43KR, R57K, Q61N, L63CF
 RenG10711RenG10711KT741739PINA  T12N, I15V, L19V, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, K70R, I72TF
 RenG10251RenG10251KT741279PINAD30N, I50L, V82AL33LF, M46MV, N88DL10V, T12I, I13V, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63C, I64L, A71V, I72L, L89IT, I93LF