<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63A
Rx PI-naive
IncludeMixtures No
References 34
Patients 57
Isolates 57
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Op de Coul (2000)CE97R101CE97R101AF204040None   K14R, I15V, E35D, M36I, R41K, R57K, L63A, E65D, L89MF
Brindeiro (2003)BRRJ921BRRJ921AY213277None   T12S, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63A, H69Y, I72T, C95SF
Shafer (2003)A384_40794079aEF549324None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, L89MF
Soares (2003)BRRJ820BRRJ820AF527326None   K14R, I15V, M36I, R41K, K45R, R57K, Q61N, L63A, C67D, I72T, V77I, C95SF
Niama (2006)CHU08CHU08FM164900None   I15V, E35D, M36I, R41K, I62V, L63A, V82VI, L89MF
Santos (2006)RG173RG173DQ344021None   G17E, E35D, M36I, R41K, R57K, Q61N, L63A, H69Y, L89MF
Vidal (2006)NV_KBS15402.KBS154AM041021None   I15V, E35D, M36I, R41K, R57K, I62V, L63A, H69Y, L89MF
Gonsalez (2007)30HIV_30GU288731None   T12S, E35D, M36I, R41K, R57K, D60E, Q61N, L63A, I64IM, V77I, L89MF
Paraschiv (2007)49834983_2004JQ083004None   L10I, T12I, I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
Varella (2007)5ini5ini None   K14R, I15V, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, C67D, I72T, V77IF
 32ini32ini None   T12Q, I15V, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, H69Y, V77I, L89MF
Ndembi (2008)CMYD-6404CMYD-64DQ990428None   L10V, I15V, K20R, M36I, R41K, I62V, L63A, I72T, L89MF
Cardoso (2009)BRGO3133BRGO3133FJ594169None   E35D, M36I, R41K, K43R, R57K, Q61D, L63A, E65D, L89MF
Cuevas (2009)X2592_1X2592_1GU326146None   E35D, M36I, R41K, R57K, Q61N, L63A, L89M, I93LF
 X2657_1X2657_1GU326163None   E35D, M36I, R41K, R57K, Q61N, L63A, L89M, I93LF
Hawkins (2009)Q242ZZQ242FJ931229None   L10I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69Q, L89M, I93LF
Koyalta (2009)28TCHAD-28FJ688182None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63A, T74S, L89MF
Vercauteren (2009)pt11206481167628GQ399904None   I13V, K14R, G17E, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, L89MF
 pt8388126543316GQ400186None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89MF
 pt7908428524942GQ400234None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89MF
Florea (2011)1091_20071091_2007JQ083019None   T12P, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63A, L89MF
Santos (2011)J78J78_PRJN010456None   G17E, E35D, M36I, R41K, R57K, Q61N, L63A, H69Y, I72T, V77I, L89MF
Alencar (2013)RJ2-0036RJ2-0036JQ237958None   E35D, M36I, P39PS, R41K, R57K, Q61N, I62V, L63A, L89MF
 PE2-0063PE2-0063JQ238150None   K14R, E35D, M36I, R41K, Q61N, L63A, L89MF
Frentz (2013)EHR-00383EHR-00383JX299541None   L10V, I15V, G16GE, G17GE, K20R, E35D, M36I, R41K, I62V, L63A, H69Q, L89MF
 EHR-38978EHR-38978JX300203None   T12N, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, V77I, L89M, Q92KF
Pircher (2013)A1013A1013JX110262None   I15IV, D29DN, E35DN, M36I, R41K, R57K, L63A, R87RK, L89MF
Temereanca (2013)SR1SR1JX966486None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63A, E65D, L89M, T91AF
 SR41SR41JX966517None   I15V, E35D, M36I, R41K, R57K, L63A, E65D, L89M, I93LF
 SR111SR111 None   T12P, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, H69Y, I72T, L89MF
Theys (2013)146583146583 None   E35D, M36I, R41K, R57K, Q61N, L63A, E65D, K70R, V77I, L89MF
Meixenberger (2014)07-0069907-00699KJ770503None   L10V, I15V, G16GE, G17GE, K20R, E35D, M36I, R41K, I62V, L63A, H69Q, L89MF
Niculescu (2014)DU910DU910KJ194751None   L10V, T12I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, L89MF
 DU3559bhDU3559bhKJ194822None   L10V, T12I, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
 DU2087DU2087KJ194760None   L10V, I13V, I15V, K20R, L23Q, E35D, M36I, R41K, R57K, L63A, E65D, K70R, L89MF
 DU3629bhDU3629bhKJ194824None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, L89MF
 DU1903DU1903KJ194803None   L10V, T12I, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, L89MF
 DU5872DU5872KJ194797None   L10V, T12I, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, L89MF
 DU375DU375KJ194742None   L10V, I15V, K20R, E35D, M36I, R41K, K45KR, R57K, I62V, L63A, E65D, L89RF
 DU281DU281KJ194741None   L10V, T12M, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
 DU3041DU3041KJ194776None   L10V, T12M, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
 DU2172DU2172KJ194761None   L10V, T12P, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, L89MF
 DU3589bhDU3589bhKJ194823None   L10V, T12IL, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, L63A, L89MF
Velasco-de-Castro (2014)05BRRJLTS22405BRRJLTS224KF922037None   T12D, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63A, I64M, L89M, I93LF
Dauwe (2015)F_11072F_11072KT863851None   L10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, D60DE, I62V, L63A, L89MF
Guimaraes (2015)BRSP487-14BRSP487-14KP115536None   I13V, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63A, V77I, L89MF
 BRSP42-14BRSP42-14KP115437None   I15V, E35D, M36IT, R41K, R57K, Q61N, L63A, V77I, L89LMF
Dos Anjos Silva (2016)AP103AP103KT737358None   L10V, T12A, K14R, I15V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63A, I72T, V77I, L89M, I93LF
 AP105AP105KT737360None   I15V, G17D, E35D, M36I, R41K, R57K, Q61N, L63A, V77I, L89MF
Hattori (2016)E09_910944E09-50910944-1AB866092None   L10V, T12TAIV, I15IV, G16GE, E35D, M36I, R41K, R57K, Q61N, L63AF
Hoenigl (2016)M1110689M1110689KU574300None   L5LFI, T12N, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, H69H*QYF
 M1212521M1212521KU574337None   T12N, I15V, G17E, L19I, E35D, M36I, R41K, R57K, Q61N, L63A, E65DF
Lima (2016)08PE11308PE113KX021000None   I15V, E35D, M36I, R41K, Q61N, L63A, L89MF
 08PE13308PE133KX020989None   I15V, E35D, M36L, R41K, R57K, Q61N, L63A, L89MF
 08PE08608PE086KX021011None   L10V, I15V, E35D, M36I, R41K, R57K, Q61D, L63A, E65D, L89MF
Pessoa (2016)10BR_RJ03610BR_RJ036KT427779None   E35D, M36I, R41K, R57K, Q61N, I62V, L63A, L89MF
Pouran Yousef (2016)343107-00699KX466333None   L10V, I15V, G16GE, G17GE, K20R, E35D, M36I, R41K, I62V, L63A, H69Q, L89MF