<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L63A
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 93
Isolates 93
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Belec (2000)r31r31_m12AF204352IDV52G48V L10V, I15V, Q18E, E35D, M36I, R41K, K43R, R57K, I62V, L63AF
Dumans (2004)RG034RG034AY390208NFV131I54V, N88SK43TL10I, K20R, E35D, M36I, R41K, R57K, D60DE, Q61N, I62IV, L63A, I93LF
Gomez-Carrillo (2004)9887798877AY365586PINA I50ISI15V, E35D, M36I, R41K, K45KN, R57K, Q61N, L63A, I93LF
 104264104264AY365697PINAL90M K14R, I15V, Q18L, E35D, M36I, R41K, R57K, Q61N, L63AF
 104338104338AY365699PINAN88S L10I, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63AF
 105247105247AY365720PINAI54V, V82A, L90M L10I, T12N, I15V, K20I, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, E65D, A71V, I85V, I93LF
 109559109559AY365823PINA  L10I, I15V, K20M, E35D, M36I, R41K, R57K, Q61N, L63A, V82I, L89M, I93LF
 110345110345AY365835PINA  Q2QP, Q7HL, L10V, T12A, K14R, I15V, K20R, M36I, N37D, R41K, R57K, Q61N, L63A, I93LF
 118074118074AY365944PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, H69Y, I72TF
 125545125545AY366048PINAI54IV, L90M T4TA, Q7QH, I15V, K20M, E35D, M36IV, R41K, R57K, Q61N, L63A, I93LF
Non-B Workgroup (2005)BR7BR7AY900887NFV130I54V, N88SK43TL10I, K20R, E35D, M36I, R41K, R57K, D60DE, Q61N, I62IV, L63A, I93LF
Rodrigues (2005)BR01510700AY441820IDV, NFV, SQV, RTV161  K14R, I15V, G16E, E35D, M36I, R41K, G52K, R57K, D60E, Q61N, L63A, I72E, G86K, L89MF
 BLF_Pat1BR03SP230AY643170IDV, Unknown>47  T12A, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, L89MF
 BLF_Pat23BR03SP224AY643169Unknown, RTV, APV>4M46MI, I50V, I54V, V82A, L90ML23I, F53L, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, I64M, L89M, I93LF
 BLF_Pat25BR02SP184AY643140NFV113L90M L10V, I15V, K20R, E35D, M36I, P39Q, R41K, R57K, Q61N, I62V, L63A, T74S, L89MF
Baxter (2006)48-10381038-30619DQ877393PINAI54V, V82A L10LI, T12S, I15V, L19LF, K20M, E35D, M36I, R41K, Q61N, L63A, A71AITVF
 48-32703270-30703DQ878175PINAM46L, I54V, V82A, L90MF53FLL10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, L89I, I93LF
 48-92179217-30908DQ877511PINAM46FL, I54V, V82A, L90ML33IL10I, I15V, K20R, E35D, M36I, N37E, R41K, K43R, R57K, Q61N, L63A, A71V, Q92K, I93LF
 48-91409140-30930DQ877734PINA  L10LV, T12N, I15V, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, L63A, E65D, K70Q, I93ILF
Dumans (2009)RENA578RENA578FJ405042IDV, SQV, RTV, NFV, LPV335M46I, I54A, V82AL24I, L33F, Q58EL10I, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, I62V, L63A, L89MF
 RES222_03RES222_03FJ405162NFV, Unknown>165L90M L10V, I15V, L19I, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, T74S, I93LF
Aulicino (2011)ARM645HLAARM645HLAFJ525836PINAM46L, I54V, V82A, L90M L10V, I15IV, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, A71V, I72T, T74S, I93LF
 ARO45GNJARO45GNJFJ525872PINAM46L, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, I93LF
 4426-M132SV4426-M132SVHQ158172PINA  L10I, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, L63A, I72T, I93LF
 4153-N651CMN4153-N651CMNHQ158178PINA  K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, H69QF
Jones (2012)128155128155JN669449PINAI54V, V82A, L90MF53LL10V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, A71V, I93LF
 137641137641JN669567PINAI54V, V82A, L90M L10I, I15V, K20R, E35D, M36I, R57K, Q61N, L63A, A71V, I93LF
 140264140264JN669587PINAM46ML, L90M I15V, K20KR, E35D, M36I, R41K, K55KR, R57K, Q61N, L63A, I64L, I72V, V77VI, I93LF
 141849141849JN669607PINA  I15V, E35D, M36I, P39PS, R41K, R57K, Q61N, L63A, H69HY, I72TF
 158844158844JN669935PINAM46I, I47V, I54V, V82SL23I, K43T, F53LL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63A, A71V, I72V, T74S, L89M, I93LF
 162845162845JN670050PINA  T12I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, I62IV, L63AF
 165203165203JN670094PINA  I15V, K20KR, M36IL, N37NS, P39PL, R41RK, R57K, Q61N, L63A, I93LF
 165415165415JN670100PINA  I15V, E35D, M36I, R41K, I62V, L63A, E65D, T74TS, L89MF
 169841169841JN670213PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, I93LF
 170845170845JN670236PINAD30NN88DI15V, K20T, E35N, M36I, P39Q, R41K, K45R, R57K, Q61DN, L63AF
 171422171422JN670259PINA  L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, I93LF
 173324173324JN670324PINA  V11VL, I15V, G16GE, K20M, A22AT, D25DV, T26TA, E35D, M36I, R41K, R57K, Q61N, L63A, I93ILF
 175482175482JN670360PINA  P9PS, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, I72VF
 176249176249JN670391PINAD30NN88DL10LI, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K43I, R57K, D60N, Q61N, L63A, V75VIF
 176630176630JN670406PINAL90M I15V, K20M, E35D, M36V, R41K, R57K, Q61N, I62IV, L63A, I93LF
 178684178684JN670487PINA  T12N, I15V, L19I, M36I, R41K, K43R, R57K, D60E, Q61D, L63AF
 181809181809JN670591PINA  K14R, E35D, M36I, R41K, R57K, Q61N, L63A, E65DF
 182295182295JN670606PINAD30NN88DL10I, T12A, K14R, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, C67D, K70KR, I72IVF
 182487182487JN670615PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, I72T, I93ILF
 182709182709JN670624PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, P79DF
 183430183430JN670647PINA  T12TA, I15V, K20M, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, I93LF
 183543183543JN670650PINA  L10V, I15V, E35D, M36I, N37ND, R41RK, R57K, D60E, Q61D, L63A, I72VF
 184084184084JN670671PINAI54V, V82AQ58EL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, H69HYF
 195444195444JN670980PINA  T12A, I15V, M36MI, R41K, R57K, Q61N, L63A, I93LF
 196720196720JN671038PINAD30NL33F, N88DI15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, T74SF
 199355199355JN671164PINA  K14KR, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, V82I, I93LF
 199498199498JN671172PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, K70KR, I93LF
 199633199633JN671178PINAD30N, M46IF53FL, N88DL10X, I13IV, I15AV, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, A71V, T74S, I85V, I93LF
 201239201239JN671217PINAG48V, I54V, V82ATQ58EL10V, I15V, G16E, K20R, E35D, M36I, P39PS, R41K, R57K, Q61N, L63AF
Diaz (2015)RenG15688RenG15688KT746716PINAN88S L10I, I15V, K20T, E35D, M36I, P39Q, R41K, R57K, Q61N, L63A, A71T, I85VF
 RenG16539RenG16539KT747567PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, L89LMF
 RenG16044RenG16044KT747072PINA  K14Q, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65DF
 RenG16704RenG16704KT747732PINAM46L, V82A L10I, T12D, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, L89MF
 RenG17487RenG17487KT748515PINAI54V, V82A, L90ML33FL10I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63A, I64M, C67S, T74S, L89M, I93LF
 RenG15778RenG15778KT746806PINA  L10V, G17E, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, L63A, E65DF
 RenG16204RenG16204KT747232PINAM46I, I54V, L76V, V82A L10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, T74S, L89MF
 RenG15758RenG15758KT746786PINA  T12M, I15V, L19S, E35D, M36I, R41K, R57K, Q61N, L63A, E65DF
 RenG16849RenG16849KT747877PINAM46IF53L, N88TL10V, I15IV, G16E, L19I, K20T, E35D, M36V, N37T, P39T, R41I, K45Q, R57K, D60DE, Q61N, I62V, L63A, E65D, V77I, L89MF
 RenG16201RenG16201KT747229PINAM46L, I54V, V82A, L90ML33F, F53L, T74TPSL10IV, G16GA, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, Q61N, I62IV, L63A, I64M, A71V, Q92KF
 RenG16788RenG16788KT747816PINA  I15V, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, E65DF
 RenG15395RenG15395KT746423PINAM46MI, L90M I13V, E35D, M36I, R41K, R57K, D60E, Q61N, I62IV, L63A, I72T, L89IMF
 RenG15046RenG15046KT746074PINA  I15V, G16E, K20R, E34EK, E35D, M36I, N37ND, P39T, R41K, R57K, D60E, Q61D, I62V, L63A, I93LF
 RenG14071RenG14071KT745099PINA  T12A, K14R, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63A, L89MF
 RenG15368RenG15368KT746396PINAV32I, I47V, I50LL33F, G73SL10I, T12N, I15V, L19I, E35D, M36I, N37E, R57K, Q61N, I62V, L63A, I66L, Q92HF
 RenG13786RenG13786KT744814PINA  T12A, I13V, I15IV, G17R, E35D, M36I, R41K, R57K, D60E, Q61D, L63A, V77VI, L89MF
 RenG13651RenG13651KT744679PINA  E35D, M36I, R41K, K43R, R57K, Q61N, L63A, I64LF
 RenG14443RenG14443KT745471PINAV32I I13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, A71V, L89TF
 RenG13883RenG13883KT744911PINA  I15V, G17D, Q18QR, L19X, K20M, E35D, M36I, R57K, Q61N, L63A, I64IV, I93ILF
 RenG12128RenG12128KT743156PINAM46MIL, I50L, V82AL33LF, Q58EL10I, K20R, E35D, M36I, R41K, K55R, Q61N, L63A, C67DF
 RenG12065RenG12065KT743093PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65DF
 RenG13001RenG13001KT744029PINA  T12K, I15V, L19I, E35ED, M36I, R41K, Q61N, L63A, E65D, L89MF
 RenG12957RenG12957KT743985PINA  T12TI, K14KR, I15V, G16GE, K20R, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, L63A, L89M, Q92KF
 RenG12247RenG12247KT743275PINAI54V, V82AF53LL10V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, K45Q, K55R, R57K, Q61N, L63A, L89MF
 RenG12171RenG12171KT743199PINAM46L, I54V, V82AL24IL10I, I15IV, G16GR, K20R, E35D, M36I, N37DE, R41K, R57K, Q61N, L63A, A71V, T74S, V77I, I93LF
 RenG12683RenG12683KT743711PINAI54V, V82TL24IL10I, T12TK, I13V, K20I, E35D, M36I, R41K, R57K, Q61N, L63A, T74S, L89IF
 RenG11940RenG11940KT742968PINA  T12TS, K14R, I15V, E35D, M36I, R41K, Q61N, L63A, L89LM, I93LF
 RenG13174RenG13174KT744202PINAI54V, V82AL24IL10I, G17D, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, E65D, L89MF
 RenG12889RenG12889KT743917PINA  T12A, I15V, L19I, E35D, M36I, R41K, R57K, Q61DN, L63A, E65ED, I72E, V77IF
 RenG11642RenG11642KT742670PINA  G16E, K20M, E35D, M36I, R57K, Q61N, L63A, I72TF
 RenG10607RenG10607KT741635PINA  I15S, G16R, G17E, K20R, E35D, M36I, K43I, R57K, Q61N, L63A, L89MF
 RenG11135RenG11135KT742163PINAM46MI, I54V, L90M I13IV, K14KR, I15V, K20T, E35D, M36I, P39V, R41K, R57K, Q61N, I62V, L63A, I72V, T74S, L89I, Q92KF
 RenG10534RenG10534KT741562PINA  L10V, I15V, E35D, M36I, N37S, R41K, R57K, Q61N, L63A, E65D, L89MF
 RenG11618RenG11618KT742646PINA  I15V, Q18QH, E35D, M36I, P39Q, R41K, K45R, R57K, Q61N, I62IV, L63A, I64IM, I93LF
 RenG11459RenG11459KT742487PINA  L10V, I15V, E35D, M36I, R41K, R57K, Q61NS, L63A, L89M, I93LF
 RenG10948RenG10948KT741976PINA  K14KR, L19LP, K20KM, E35D, M36I, R41K, R57K, Q61N, L63AF
 RenG10550RenG10550KT741578PINAD30NL33LI, Q58EI13V, K20T, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, L63A, I64IM, A71IV, V77VI, L89T, I93LF
 RenG11765RenG11765KT742793PINA  L10V, I15V, E35D, M36I, P39A, R41K, R57K, Q61N, L63A, G86GR, L89MF
 RenG11372RenG11372KT742400PINA L23IL10I, I15V, K20T, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, A71T, I72T, V77I, L89T, I93LF