<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation Q58E
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 93
Isolates 93
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Brindeiro (2002)TVGG21TVGG21AY145827RTV65I54V, V82AQ58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, E65DF
Dumans (2004)RG070RG070AY390210IDV, RTV, Unknown>178M46I, I54V, V82SL24I, F53FL, Q58EL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, A71V, L89M, I93LF
Gomez-Carrillo (2004)9629696296AY365523PINAI54V, V82AG, I84V, L90ML33F, Q58EQ7QH, L10I, T12TP, I13IV, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, A71V, I72RF
 103520103520AY365682PINAI54V, V82A, L90MQ58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, L63P, A71V, I93LF
 109497109497AY365819PINAM46L, I54V, V82A, L90MQ58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, A71V, Q92K, I93L, C95FF
 110390110390AY365836PINAI54ML33F, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I85VF
 114305114305AY365896PINAD30NQ58E, N88DL10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72V, V77I, I93LF
Rodrigues (2005)BLF_Pat22BR03SP87AY643178RTV, NFV, APV217M46L, I54V, V82AL24I, Q58EL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, T74A, L89MF
Baxter (2006)48-11921192-30929DQ877270PINAM46I, I50IV, I54V, L76LV, V82AL33LF, Q58EL10IV, G16GE, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, L63T, E65D, I72T, L89MF
 48-12061206-30604DQ877750PINAM46L, I50V, I54V, V82AL24I, L33F, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63Q, H69Y, L89MF
 48-12711271-30923DQ877792PINAG48V, I54V, V82SL24I, L33F, Q58EL10I, I15V, G16E, K20R, E34Q, E35D, M36I, P39PT, R41K, R57K, I62V, L63T, E65D, I72T, L89MF
 48-93319331-30929DQ877549PINAM46L, I54V, V82A, L90MQ58EL10I, K20R, M36I, I62V, L63P, A71V, T74S, I93LF
 48-90949094-30827DQ877653PINAV32I, M46I, I47V, I54V, V82AL24LI, L33F, Q58EL10I, I15V, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63PF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
 135135PRAY275781IDV, Unknown, RTV>163I54V, V82AQ58EL10V, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, L89MF
Dumans (2009)RENA578RENA578FJ405042IDV, SQV, RTV, NFV, LPV335M46I, I54A, V82AL24I, L33F, Q58EL10I, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, I62V, L63A, L89MF
Aulicino (2011)ARL550FANARL550FANFJ525810PINAI54V, V82A, L90MI50T, Q58EL10I, I15V, Q18E, E35D, M36L, L38W, R41K, R57K, Q61N, I62V, L63P, A71V, I93LF
 ARM616GGWARM616GGWFJ525834PINAM46L, I54V, V82AL24I, Q58ET4TA, L10V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, D60E, Q61N, I64VF
 ARM730WDARM730WDFJ525838PINAI54V, V82AL24I, F53L, Q58E, N83DL10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71VF
 ARN204SBDARN204SBDFJ525854PINAM46MI, I47IV, I54V, V82F, L90MQ58EL10IV, I15V, G17D, K20T, E35N, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, I72R, V77I, I93LF
 ARN311BMSARN311BMSFJ525857PINAM46L, G48Q, I54V, L76V, V82A, L90MV32L, F53L, Q58EL10V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, D60E, Q61N, I62V, L63P, I64V, A71V, T74S, V77I, I93LF
 ARO26PJARO26PJFJ525871PINAM46L, G48V, I54V, V82AQ58EL10I, K14R, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61N, I62V, L63T, E65D, I72VF
Jones (2012)145844145844JN669665PINAI54V, V82A, L90MF53L, Q58EL10I, I15V, G16E, K20R, E35D, M36V, R41K, K55R, R57K, Q61N, L63T, A71V, I72IATV, I93LF
 146264146264JN669673PINAI54V, V82A, L90MF53FL, Q58EL10IV, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I93ILF
 157416157416JN669883PINAM46I, I50V, I54V, L76V, V82A, L90LMQ58E, L89VL10I, I15V, K20R, E35D, M36I, R41K, K55KR, R57RK, D60E, Q61N, I62V, L63P, A71V, G73DE, I85V, Q92K, I93LF
 160595160595JN669984PINAM46L, I54V, V82A, L90MQ58EL10V, I15V, K20R, E35D, M36I, Q61N, I62IV, L63P, I72V, R87RK, L89M, Q92KF
 162645162645JN670045PINAI54V, V82A, I84V, L90ML23I, Q58EL10I, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63C, I64V, A71V, V77I, I93LF
 163030163030JN670052PINAM46L, I54V, V82AQ58EL10V, I15V, K20R, E35D, M36I, R57K, D60E, Q61G, L63P, T74SF
 163240163240JN670058PINAI54V, V82A, L90MQ58EL10V, I15V, G16A, K20R, E35D, M36I, N37D, R41K, K43R, R57K, Q61D, L63P, I72V, I93IVF
 169723169723JN670207PINAI54L, L90ML33F, Q58EL10LI, I15V, L19LI, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72IM, V75IF
 170453170453JN670221PINAI54V, V82AQ58EL10IV, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, H69Y, I72TF
 175931175931JN670380PINAI54V, V82AQ58EL10V, T12N, I15V, G16GE, K20RS, E35D, M36I, N37T, R41K, R57K, Q61N, L63T, E65EDF
 177288177288JN670432PINAM46I, I50V, I54A, V82A, L90ML33F, Q58E, L89VL10I, I13V, I15V, G16Q, K20R, E35N, M36I, P39Q, R41K, K55R, R57K, Q61N, L63P, A71V, I93ILF
 179226179226JN670504PINAD30N, I54V, L90MV11VI, Q58E, N88DI15V, K20IMT, E35NS, M36I, N37D, R41K, R57K, Q61N, L63P, A71T, I72TF
 181091181091JN670565PINAM46I, I47V, I54V, L76V, V82AQ58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I72T, I93LF
 181854181854JN670592PINAD30N, M46LQ58EI15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61D, L63P, G68DF
 184084184084JN670671PINAI54V, V82AQ58EL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63A, H69HYF
 184896184896JN670689PINAM46I, I54V, V82T, I84V, L90ML33F, Q58EL10V, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V, I85V, L89M, I93LF
 190428190428JN670798PINAM46L, I54V, L76V, V82A, L90MQ58EL10V, I15V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V, I72V, I93LF
 192047192047JN670844PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, G16E, K20R, E35D, M36I, R41RK, K55R, R57K, D60E, Q61N, I62IV, L63C, E65ED, L89MF
 192661192661JN670862PINAI54V, V82AQ58EL10V, I15V, K20R, D25DG, E35D, M36I, R41K, R57K, Q61N, T74A, L89MF
 195789195789JN671000PINAM46I, I54V, V82AL24I, Q58EL10V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61DN, I62V, L63P, A71IV, I72IM, L89TF
 196218196218JN671018PINAV82TQ58EQ2P, L10I, T12K, K14Q, I15V, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, E65D, I72T, L89LP, I93LF
 199882199882JN671185PINAM46L, I54V, V82AL24I, Q58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, V77IF
 201239201239JN671217PINAG48V, I54V, V82ATQ58EL10V, I15V, G16E, K20R, E35D, M36I, P39PS, R41K, R57K, Q61N, L63AF
 204754204754JN671350PINAM46I, I50V, I54V, V82AL33F, Q58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
Diaz (2015)RenG16086RenG16086KT747114PINAD30NQ58E, N88DK20T, E35D, M36I, R41K, R57K, Q61N, L63P, V77I, L89MF
 RenG17206RenG17206KT748234PINAM46I, I47V, I54V, V82A, L90ML33F, F53L, Q58EL10I, I13V, Q18IL, L19V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, I66F, A71T, I72IM, L89I, Q92KF
 RenG17085RenG17085KT748113PINAM46L, I47V, I54V, V82AL24I, L33F, F53L, Q58EL10I, G16A, K20R, E34EV, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63D, E65D, A71V, I72T, I93LF
 RenG15941RenG15941KT746969PINAI54IV, I84IVQ58EL10LI, T12TA, Q18QE, L19LI, K20KR, E35D, M36I, R41RK, R57RK, D60E, Q61N, L63PT, V77I, L89MF
 RenG15968RenG15968KT746996PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG17249RenG17249KT748277PINAI54V, V82AL24I, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, L89MF
 RenG15721RenG15721KT746749PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, L19V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63T, H69Y, I72T, L89M, I93LF
 RenG15796RenG15796KT746824PINAG48V, I50V, I54AV, V82AL24LI, L33LF, Q58EL10I, G16GA, K20R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, L63LP, E65D, V77VI, L89MF
 RenG14507RenG14507KT745535PINAM46I, I47V, I54V, V82AF53L, Q58EL10V, K14R, G17E, L19V, K20R, E35D, M36I, N37D, R41RK, K55R, R57K, Q61N, L63T, E65D, I72T, V77I, L89MF
 RenG14829RenG14829KT745857PINAN88SL33I, Q58EL10I, T12E, I15V, E35N, M36I, P39Q, R41K, R57K, D60E, Q61D, L63Q, I85V, L89MF
 RenG14526RenG14526KT745554PINAD30N, M46I, I47V, I54V, V82A, L90ML33F, F53L, Q58E, N88DL10V, T12K, I15V, G16Q, K20T, E35S, M36I, P39S, R41K, K45R, R57K, D60E, Q61D, L63P, A71I, L89IF
 RenG13826RenG13826KT744854PINAD30N, I54V, V82AL33LF, Q58E, N88DL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41RK, K45KR, R57K, D60N, Q61N, L63P, I72V, V75I, I93LF
 RenG14109RenG14109KT745137PINA Q58EL10I, T12TI, I13V, E35D, M36I, R41K, K45KR, R57K, Q61N, L63AT, V77I, L89MF
 RenG13656RenG13656KT744684PINAV32I, M46I, I47V, I54V, V82A, L90ML10F, Q58EI15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61N, L63P, A71V, L89I, I93LF
 RenG15255RenG15255KT746283PINAM46I, I47IV, I54IM, L90ML33F, F53FL, Q58EL10V, I15V, G16E, K20T, E35D, M36IV, P39S, K55R, R57K, Q61N, I62IV, L63T, I72T, T74S, L89MF
 RenG14011RenG14011KT745039PINAI54L, L76V, V82FL33F, Q58EL10V, T12I, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, R57K, Q61N, A71V, I72R, V77I, L89IM, I93LF
 RenG13850RenG13850KT744878PINAM46I, I54V, L76V, V82SL24I, L33F, Q58EL10I, I13V, L19I, K20M, E35N, M36I, N37E, K55R, R57K, D60E, Q61N, L63P, C67Q, K70R, I72V, L89MF
 RenG14160RenG14160KT745188PINAM46L, I54V, V82AL24I, L33F, Q58EL10I, K14T, L19Q, K20R, E35D, M36I, K55R, R57K, D60E, Q61N, I62V, L63P, E65D, I72IM, L89I, Q92KF
 RenG14687RenG14687KT745715PINAI50L, N88SQ58EL10V, I15V, G16GE, K20T, E35D, M36I, R41K, R57K, Q61N, L63LP, T74TA, V77I, L89MF
 RenG14222RenG14222KT745250PINAI54V, V82F, L90MQ58EL10I, I15L, G16A, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63C, A71V, I72T, V77I, L89M, I93LF
 RenG14993RenG14993KT746021PINAM46I, I54V, L76V, V82AQ58EL10LR, T12A, K14R, I15V, G16E, E35N, M36IV, N37D, R41K, K55R, R57K, D60E, Q61D, L63T, I72T, L89MF
 RenG12128RenG12128KT743156PINAM46MIL, I50L, V82AL33LF, Q58EL10I, K20R, E35D, M36I, R41K, K55R, Q61N, L63A, C67DF
 RenG12344RenG12344KT743372PINAM46I, I54V, L76V, V82FL33LF, Q58EL10V, I15V, K20R, E35D, M36I, R41K, K55KR, R57K, D60E, Q61D, I62V, L63LP, H69Y, A71AV, I72T, L89M, I93LF
 RenG11951RenG11951KT742979PINAM46I, I54V, L76V, V82FL33LF, Q58EL10V, I15V, K20R, E35D, M36I, R41K, K55KR, R57K, D60E, Q61D, I62V, L63LP, H69Y, A71AV, I72T, L89M, I93LF
 RenG12483RenG12483KT743511PINAV32I, I47V, G48M, I54T, V82AL33F, Q58EL10V, T12I, I13IV, I15V, K20R, E34N, E35D, M36I, N37E, R41K, R57K, D60E, Q61N, I62V, I72V, T74S, V77VI, L89MF
 RenG12901RenG12901KT743929PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG12258RenG12258KT743286PINAM46I, I47V, I54V, V82AQ58EL10V, K20R, E35DN, M36I, N37DE, R41K, R57K, Q61N, I62IV, E65D, I72V, L89MF
 RenG12449RenG12449KT743477PINAM46I, I54A, V82L, L90MQ58EL10I, K14R, I15V, G16Q, K20T, E35N, M36V, N37S, P39S, R41K, F53FY, R57K, D60E, Q61N, L63T, C67E, H69Y, A71V, I72T, V77I, I93LF
 RenG11848RenG11848KT742876PINA Q58EI15V, E35D, M36I, P39Q, R41K, R57K, D60E, Q61N, L63T, I72V, T74S, L89MF
 RenG12717RenG12717KT743745PINAM46I, I54V, L76V, V82AV32VL, Q58EL10I, I15V, K20R, E35D, M36I, N37E, R57K, D60E, Q61N, L63P, I93LF
 RenG11967RenG11967KT742995PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG12893RenG12893KT743921PINAM46I, I50V, I54V, V82A, L90MQ58EL10V, I15V, G16E, K20R, E35D, M36V, P39S, R41K, K55R, R57K, D60E, Q61N, L63T, E65D, A71V, I72T, V77VI, L89M, I93LF
 RenG11946RenG11946KT742974PINAM46L, N88SQ58EL10V, K20T, E35D, M36I, R57K, Q61N, I62V, L63S, E65D, I72T, V77I, L89M, I93LF
 RenG12087RenG12087KT743115PINAM46L, I54V, L76V, V82MQ58EL10I, I13V, I15V, K20T, E35DN, M36I, R41K, R57K, Q61N, I62V, E65D, T74S, L89MF
 RenG13021RenG13021KT744049PINAN88SF53L, Q58EL10I, G16E, K20T, E35D, M36V, N37H, P39S, R41K, R57K, D60E, Q61D, L63C, A71V, V77IL, L89M, I93LF
 RenG11950RenG11950KT742978PINAM46I, I54V, L76VQ58ET12K, K14M, I15V, G16E, K20T, E35D, M36I, N37E, R57K, Q61N, L63R, E65D, L89MF
 RenG10683RenG10683KT741711PINAM46I, I54V, N88SL33I, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I93LF
 RenG10514RenG10514KT741542PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, K20R, E35D, M36I, N37K, R41K, K55R, R57K, Q61N, I62IV, L63P, I72V, P79A, L89FF
 RenG10674RenG10674KT741702PINAI54V, V82LL24I, Q58EL10I, I15V, L19I, K20R, E35D, M36I, N37NS, R57K, D60E, Q61D, I62V, L63P, L89TF
 RenG11279RenG11279KT742307PINAG48V, I54V, L76V, V82A, I84VM46V, Q58EL10I, I15V, G16E, K20R, E35D, M36I, K55R, R57K, Q61N, L63C, L89IF
 RenG10656RenG10656KT741684PINAD30N, M46LL23I, F53L, Q58E, N88DL10I, T12I, I13V, I15V, G16E, K20T, E35D, M36V, P39S, R41K, R57K, Q61N, I62V, A71T, I72R, V77I, L89TF
 RenG11633RenG11633KT742661PINAM46L, N88SQ58EL10V, I13V, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, V77I, L89MF
 RenG11155RenG11155KT742183PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63S, L89MF
 RenG11198RenG11198KT742226PINA Q58EL10I, K20M, E35D, M36I, R41K, R57K, Q61N, L63T, I72V, L89M, I93LF
 RenG11029RenG11029KT742057PINAV32IQ58EW6WG, L10V, T12P, K14R, I15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, G68E, A71V, I85V, L89TF
 RenG10550RenG10550KT741578PINAD30NL33LI, Q58EI13V, K20T, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, L63A, I64IM, A71IV, V77VI, L89T, I93LF
 RenG10068RenG10068KT741096PINAM46I, I54V, L76V, V82AQ58EL10I, I15V, E35D, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63S, L89MF